“…9,11 The differentiation between COM (being formed as monohydrated) and TRA (coming from the transformation of COD), in any of the transformation stages, is of great importance since their origins are caused by different pathologies, for example, COD nephroliths are related to hypercalciuria, while COM ones are related to hyperoxaluria. 9,12,13 Therefore, the study of this transformation process, as well as the stabilization of the dihydrated species, is very important to understand the physiopathology, to propose adequate treatment and, to prevent the patients' recurrence. 9,14,15 The matrix of kidney stones, including the oxalocalcic ones, is not only formed by crystalline phases; there are also macromolecules (organic matter), such as, proteins, lipids, carbohydrates, and glycosaminoglycans, 16 as well as trace elements, such as, Zn an Sr ions, 17 incorporated into the crystals structures.…”