Chemokines: the past, the present and the future

Tang, Peng; Wang, Ji Ming

doi:10.1038/cmi.2018.9

Cited by 24 publications

(15 citation statements)

References 15 publications

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“…CCR2 functions by binding to different ligands, including CCL2, CCL7, CCL8, CCL12, CCL13 and CCL16, leading to the redundancy and promiscuity of the chemokine family. Nevertheless, it is this redundancy that has evolutionary significance for maintaining chemokine system activity and stability 31 . Meanwhile, among the different ligands known to bind to CCR2, CCL2 has significantly higher activity than the other ligands 32 …”

Section: Biological Characteristics Of the Ccl2‐ccr2 Signalling Axismentioning

confidence: 99%

Role of the CCL2‐CCR2 signalling axis in cancer: Mechanisms and therapeutic targeting

et al. 2021

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The chemokine ligand CCL2 and its receptor CCR2 are implicated in the initiation and progression of various cancers. CCL2 can activate tumour cell growth and proliferation through a variety of mechanisms. By interacting with CCR2, CCL2 promotes cancer cell migration and recruits immunosuppressive cells to the tumour microenvironment, favouring cancer development. Over the last several decades, a series of studies have been conducted to explore the CCL2‐CCR2 signalling axis function in malignancies. Therapeutic strategies targeting the CCL2‐ CCR2 axis have also shown promising effects, enriching our approaches for fighting against cancer. In this review, we summarize the role of the CCL2‐CCR2 signalling axis in tumorigenesis and highlight recent studies on CCL2‐CCR2 targeted therapy, focusing on preclinical studies and clinical trials.

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Section: Biological Characteristics Of the Ccl2‐ccr2 Signalling Axismentioning

confidence: 99%

Role of the CCL2‐CCR2 signalling axis in cancer: Mechanisms and therapeutic targeting

et al. 2021

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“…It is clear that chemokine expression is critical for the inflammatory response, and an increase in chemokine expression is associated with a wide range of inflammatory diseases. These proteins are involved in both innate and adaptive immunity, and play important roles in leukocyte recruitment and organ positioning, integrin activation, leukocyte degranulation, angiogenesis, and monocyte surveillance (16,17).…”

Section: Introductionmentioning

confidence: 99%

Bidirectional Regulation of Opioid and Chemokine Function

Rogers

2020

Front. Immunol.

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The opioid family of GPCRs consists of the classical opioid receptors, designated µ-, κ-, and δ-opioid receptors, and the orphanin-FQ receptor, and these proteins are expressed on both neuronal and hematopoietic cells. A number of laboratories have reported that an important degree of cross-talk can occur between the opioid receptors and the chemokine and chemokine receptor families. As a part of this, the opioid receptors are known to regulate the expression of certain chemokines and chemokine receptors, including those that possess strong pro-inflammatory activity. At the level of receptor function, it is clear that certain members of the chemokine family can mediate cross-desensitization of the opioid receptors. Conversely, the opioid receptors are all able to induce heterologous desensitization of some of the chemokine receptors. Consequently, activation of one or more of the opioid receptors can selectively cross-desensitize chemokine receptors and regulate chemokine function. These cross-talk processes have significant implications for the inflammatory response, since the regulation of both the recruitment of inflammatory cells, as well as the sensation of pain, can be controlled in this way.

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“…Acting as a chemokine, MCP-1 is one of the first molecules mobilized in response to inflammatory challenges (Tang and Wang, 2018). In humans, increased expression of MCP-1 in cells from the stromal vascular fraction in AT recruit macrophages infiltrating into AT leading to a low-grade inflammatory status (Capurso and Capurso, 2012).…”

Section: Cytokinesmentioning

confidence: 99%

Symposium review: Adipose tissue endocrinology in the periparturient period of dairy cows

Häußler

Sadri

Ghaffari

et al. 2022

Journal of Dairy Science

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The involvement of adipose tissue (AT) in metabolism is not limited to energy storage but turned out to be much more complex. We now know that in addition to lipid metabolism, AT is important in glucose homeostasis and AA metabolism and also has a role in inflammatory processes. With the discovery of leptin in 1994, the concept of AT being able to secrete messenger molecules collectively termed as adipokines, and acting in an endo-, para-, and autocrine manner emerged. Moreover, based on its asset of receptors, many stimuli from other tissues reaching AT via the bloodstream can also elicit distinct responses and thus integrate AT as a control element in the regulatory circuits of the whole body's functions. The protein secretome of human differentiated adipocytes was described to comprise more than 400 different proteins. However, in dairy cows, the characterization of the physiological time course of adipokines in AT during the transition from pregnancy to lactation is largely limited to the mRNA level; for the protein level, the analytical methods are limited and available assays often lack sound validation. In addition to proteinaceous adipokines, small compounds such as steroids can also be secreted from AT. Due to the lipophilic nature of steroids, they are stored in AT, but during the past years, AT became also known as being able to metabolize and even to generate steroid hormones de novo. In high-yielding dairy cows, AT is substantially mobilized due to increased energy requirements related to lactation. As to whether the steroidogenic system in AT is affected and may change during the common loss of body fat is largely unknown. Moreover, most research about AT in transition dairy cows is based on subcutaneous AT, whereas other depots have scarcely been investigated. This contribution aims to review the changes in adipokine mRNA andwhere available-protein expression with time relative to calving in high-yielding dairy cows at different conditions, including parity, body condition, diet, specific feed supplements, and health disorders. In addition, the review provides insights into steroidogenic pathways in dairy cows AT, and addresses differences between fat depots where possible.

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Chemokines: the past, the present and the future

Cited by 24 publications

References 15 publications

Role of the CCL2‐CCR2 signalling axis in cancer: Mechanisms and therapeutic targeting

Role of the CCL2‐CCR2 signalling axis in cancer: Mechanisms and therapeutic targeting

Bidirectional Regulation of Opioid and Chemokine Function

Symposium review: Adipose tissue endocrinology in the periparturient period of dairy cows

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