Chemistry and heterocyclization of thiosemicarbazones

Abstract

The review summarizes the literatures dealing with the synthesis of thiosemicarbazone derivatives, chemical reactions and their applications in the synthesis of important heterocyclic as well as fused heterocyclic compounds J. Heterocyclic Chem., (2012).

Synthesis and antiviral activity of camphor-based 1,3-thiazolidin-4-one and thiazole derivatives as Orthopoxvirus-reproduction inhibitors

“…Thiosemicarbazones are particularly suitable substrates for the preparation of nitrogen-sulphur containing heterocycles such as 1,3-thiazolidin-4-one and thiazoles. 5 It is worth noting that some thiosemicarbazone compounds have prophylactic activity against smallpox disease and therapeutic activity against VV infections. 6 Thus, thiosemicarbazone compounds is perspective scaffold for create Orthopoxvirus inhibitors.…”

Synthesis and the hypoglycemic activity of pyrazolidene-3-carboxylic acids and their derivatives exo-functionalized with the hydrazinilidene-1,3-thiazolidine fragment

“…Відомо, що тіосемікарбазони є ефективними синтетичними блоками для побудови різноманітних типів гетероциклічних систем [17]. Зокрема, на їх взаємодії з α-галогенокарбонільними сполуками базується синтез поліфункціональних тіазолів [18][19][20].…”

Synthesis and mass spectrometry of some arylidene-hydrazinyl-thiazolines and their 2-arylidene-N-(3-chlorophenyl)hydrazinecarbothioamide precursors

“…Thioacetazone is one of the oldest and cheapest antibiotics used as a second line drug for tuberculosis treatment [7]. Aldehyde thiosemicarbazones are also appropriate substrates for the preparation of five or six membered heterocyclic rings that contain two heteroatoms such on treating them with oxidizing or other cyclizing agents [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. In this context, nitrogen and sulfur-containing 4-thiazolines (2,3-dihydrothiazoles) and their derivatives are considered as important classes of heterocyclic compounds due to their frequent appearance in natural products and medicinal drugs [23][24][25].…”