The review summarizes the literatures dealing with the synthesis of thiosemicarbazone derivatives, chemical reactions and their applications in the synthesis of important heterocyclic as well as fused heterocyclic compounds J. Heterocyclic Chem., (2012).

Substituted thiosemicarbazones 7a-e reacted with ethenetetracarbonitrile (TCNE) in ethyl acetate with formation

Ring closure reactions O 0130 Synthesis of Novel Thiazole and Pyrrolothiadiazine Derivatives from Aldehyde Thiosemicarbazones. -Substituted thiosemicabazones (I) react with tetracyanoethylene (II) to form heterocyclic compounds of type (III)-(V). A plausible mechanism for the formation of the products is given. -(GOMAA, M. A.-M.; HASSAN*, A. A.; SHEHATTA, H. S.; Heteroat. Chem. 17 (2006) 4, 261-266; Dep. Chem., Fac. Sci., El-Minia Univ., El-Minia 61519, Egypt; Eng.) -M. Bohle 38-041

SHAWKY, A. M.; SHEHATTA, H. S.; J. Heterocycl. Chem. 49 (2012) 1, 21-37, http://dx.

2-Substituted ylidene-N-phenylhydrazinecarbothioamides 1a-f reacted with 2,3-dicyano-5,6-dichloro-1,4-benzoquinone, 2,3,5,6-tetrachloro-1,4-benzoquinone, 2,3-dichloro-1,4-naphthoquinone, 2,3-dicyano-1,4-naphthoquinone and 3,4,5,6-tetrachloro-1,2-benzoquinone to form substituted N-phenylindazolecarbothioamides, substituted benzindazolecarbothioamides and substituted benzophthalazinediones. Rationales for the role of benzo-and naphthoquinones in heterocyclization of compounds 1a-f are presented.