Chemistry and Antiviral Activity of Arrabidaea pulchra (Bignoniaceae)

Brandão, Geraldo Célio; Kroon, Erna Geessien; Souza, Danielle E. R.; Filho, José Dias de Souza; Oliveira, Alaı́de Braga de

doi:10.3390/molecules18089919

Cited by 37 publications

(45 citation statements)

References 19 publications

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“…Verbascoside (Figure 1) is obtained from plant species such as, Ansbidaea pulchra , Buddleja brasiliensis , Verbasom phlomoides , Penstemon barbatus and Retzia capensis [220–224]. It is recognized for its anti-inflammatory [225], anti-tumor [226], analgesic [227], neuroprotective [228] and antihypertensive [229] properties as demonstrated in several in vitro and in vivo studies.…”

Section: Pkc Modulation By Polyphenolsmentioning

confidence: 99%

Polyphenol compounds and PKC signaling

Das

Ramani

Suraju

2016

Biochimica et Biophysica Acta (BBA) - General Subjects

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Background Naturally occurring polyphenols found in food sources provide huge health benefits. Several polyphenolic compounds are implicated in the prevention of disease states, such as cancer. One of the mechanisms by which polyphenols exert their biological actions is by interfering in the protein kinase C (PKC) signaling pathways. PKC belongs to a superfamily of serine-threonine kinase and are primarily involved in phosphorylation of target proteins controlling activation and inhibition of many cellular processes directly or indirectly. Scope of review Despite the availability of substantial literature data on polyphenols' regulation of PKC, no comprehensive review article is currently available on this subject. This article reviews PKC-polyphenol interactions and its relevance to various disease states. In particular, salient features of polyphenols, PKC, interactions of naturally occurring polyphenols with PKC, and future perspective of research on this subject are discussed. Major conclusions Some polyphenols exert their antioxidant properties by regulating the transcription of the antioxidant enzyme genes through PKC signaling. Regulation of PKC by polyphenols is isoform dependent. The activation or inhibition of PKC by polyphenols has been found to be dependent on the presence of membrane, Ca2+ ion, cofactors, cell and tissue types etc. Two polyphenols, curcumin and resveratrol are in clinical trials for the treatment of colon cancer. General significance The fact that 74% of the cancer drugs are derived from natural sources, naturally occurring polyphenols or its simple analogs with improved bioavailability may have the potential to be cancer drugs in the future.

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Section: Pkc Modulation By Polyphenolsmentioning

confidence: 99%

Polyphenol compounds and PKC signaling

Das

Ramani

Suraju

2016

Biochimica et Biophysica Acta (BBA) - General Subjects

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“…Some viral diseases such as dengue or dengue fever (DF), herpes, smallpox, and encephalomyocarditis have a high impact in public health in the tropical and subtropical regions of the world [1]. …”

Section: Introductionmentioning

confidence: 99%

“…It is estimated that 390 million cases occur every year around the world and it is endemic in more than 100 countries, including the Americas, Southeast Asia, and Western Pacific, regions most seriously affected [1, 2]. No effective drug as well as no vaccine is available for human use.…”

Section: Introductionmentioning

confidence: 99%

Antiviral Activity of Fridericia formosa (Bureau) L. G. Lohmann (Bignoniaceae) Extracts and Constituents

Brandão

Kroon

Filho

et al. 2017

Journal of Tropical Medicine

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A phytochemical study of Fridericia formosa (Bignoniaceae) ethanol extracts of leaves, stems, and fruits was guided by in vitro assays against vaccinia virus Western Reserve (VACV-WR), human herpes virus 1 (HSV-1), murine encephalomyocarditis virus (EMCV), and dengue virus type 2 (DENV-2) by the MTT method. All the ethanol extracts were active against DENV-2, HSV-1, and VACV-WR with best results for the fruits extract against DENV-2 (SI > 38.2). For VACV-WR and HSV-1, EC50 values > 200 μg mL−1 were determined, while no inhibition of the cytopathic effect was observed with EMCV. Five compounds were isolated and identified as the C-glucosylxanthones mangiferin (1), 2′-O-trans-caffeoylmangiferin (2), 2′-O-trans-coumaroylmangiferin (3), 2′-O-trans-cinnamoylmangiferin (5), and the flavonoid chrysin (4). The most active compound was 2′-O-trans-coumaroylmangiferin (3) with SI > 121.9 against DENV-2 and 108.7 for HSV-1. These results indicate that mangiferin cinnamoyl esters might be potential antiviral drugs.

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“…Some of these compounds presented have antiviral activity [ 3 ]. A previous work has shown that Bignoniaceae species are promising sources of antiviral compounds [ 5 – 10 ], including phenylethanoids [ 6 , 8 ], which justifies the studies of the antiviral activity in the species of the genus Tecoma , an important group of plants belonging to this botany family. The data obtained in the present study using chromatographic analyzes combined with hyphenated spectrometric techniques showed that the ethanolic extracts of the species under study were rich in phenylethanoids.…”

Section: Introductionmentioning

confidence: 99%

Anti-Zika virus activity and chemical characterization by ultra-high performance liquid chromatography (UPLC-DAD-UV-MS) of ethanol extracts in Tecoma species

Reis

Silva

Moura

et al. 2020

BMC Complement Med Ther

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Background Plant species from the genus Tecoma are found in tropical and subtropical regions around the world. Some of them are grown as ornamental plants and others can be used as medicinal plants. In the present study, ethanolic extracts from trunks and leaves of Tecoma species were tested in vitro using assays against the Zika virus. Methods There was a total of 8 extracts obtained from different anatomical parts of three Tecoma species. The Tecoma castaneifolia , T. garrocha , T. stans var. angustata and T. stans var. stans were prepared by percolation with ethanol. The antiviral activity was assayed in vitro against the Zika virus by the MTT colorimetric method ( n = 3). The UPLC-DAD-MS analysis of ethanolic extracts was performed from all the studied species. The biofractionation of T. stans var. stans trunk extract using different separation techniques led to the isolation of crenatoside compound. Results Ethanolic extract from Tecoma species leaves were more active against the Zika virus (EC 50 149.90 to 61.25 μg/mL) when compared to the trunk extracts tested (EC 50 131.0 to 66.79 μg/mL and two were not active). The ethyl acetate and aqueous fractions obtained from T. stans var. stans trunk were active against the Zika virus with EC 50 values of 149.90 and 78.98 μg/mL, respectively. Crenatoside is a phenylethanoid glycoside isolated from the ethyl acetate of T. stans var. stans trunk extract. This compound was tested and exhibited EC 50 34.78 μM (21.64 μg/mL), thus demonstrating a better result than the original ethanolic extracts as well as others extracts of Tecoma species, and it was more active than the positive control, ribavirin (386.84 μM). Furthermore, its selectivity index was at least 2.5 times higher than the tested ethanolic extracts and 11.1 times more potent than ribavirin. Conclusion The Tecoma species demonstrated interesting in vitro activity against the Zika virus . The crenatoside, phenylethanoid glycoside that was for the first time isolated from Tecoma stans var. stans , exhibited a potent and relevant anti- Zika virus activity, being more active than ribavirin (positive ...

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Chemistry and Antiviral Activity of Arrabidaea pulchra (Bignoniaceae)

Cited by 37 publications

References 19 publications

Polyphenol compounds and PKC signaling

Polyphenol compounds and PKC signaling

Antiviral Activity of Fridericia formosa (Bureau) L. G. Lohmann (Bignoniaceae) Extracts and Constituents

Anti-Zika virus activity and chemical characterization by ultra-high performance liquid chromatography (UPLC-DAD-UV-MS) of ethanol extracts in Tecoma species

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