Antiviral Activity of<i> Fridericia formosa</i> (Bureau) L. G. Lohmann (Bignoniaceae) Extracts and Constituents

Brandão, Geraldo Célio; Kroon, Erna Geessien; Filho, José Dias de Souza; Oliveira, Alaı́de Braga de

doi:10.1155/2017/6106959

Cited by 13 publications

(14 citation statements)

References 31 publications

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“…The phytochemical characterization by TLC and UPLC-EM and the antiviral activity of Cissus erosa observed in this study are in agreement with the literature data, since poliphenols, like flavonoids are one of the major class of secondary metabolites with antiviral activity against several viruses (Kamboj et al 2012;Johari et al 2012;Brandão et al 2017).…”

Section: Discussionsupporting

confidence: 91%

Antiviral activity and chemical characterization of Cissus erosa (Vitaceae) ethanol extracts

et al. 2020

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Cissus erosa (Vitaceae), popularly known in Brazil as Cipó-fogo, is a medicinal plant used in the treatment of warts and external ulcers. The present study aimed to evaluate the activity of stems and leaves ethanol extracts of C. erosa against the Dengue and Zika virus by the MTT colorimetric method and to carry on the phytochemical characterization of active extracts by high performance liquid chromatography coupled to mass spectrometry (UPLC-MS). Only the leaves ethanol extract showed anti-Dengue virus activity EC50 18.2 µg/ml (SI > 27.5) and low cytotoxicity for LLCMK2 cells (CC50 > 500 mg/ml). Both extracts (stems and leaves) showed anti-Zika virus activity with EC50 of 45.8 mg/ml and 82.8 mg/ml, respectively. These extracts presented CC50 of 309.2 µg/ml (leaves) and 387.6 µg/ml (stems) to Vero cells. Analysis by CCD and HPLC-DAD detected the presence of triterpenes, steroids, flavonoids and tannins. UPLC-MS analyses of these extracts, allowed the identification of the majority of flavonoids present known as vitexin, isovitexin, orientin, isoorientin and two flavones derivatives, methoxyluteolin-6(8)-C-hexosyl and luteolin-7,4’-di-O-glycosylflavone. The results of the phytochemical studies here described suggest that flavonoids and terpenoids are the substances that contribute to the antiviral activity of the ethanol extracts within this species.

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Section: Discussionsupporting

confidence: 91%

Antiviral activity and chemical characterization of Cissus erosa (Vitaceae) ethanol extracts

et al. 2020

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“…For the other plants indicated for the purpose of mitigating malnutrition, the studies found do not correlate directly with these properties, but show that they are special with high therapeutic potential. Thus, Brandão et al (2017) demonstrate that extracts of leaves, stems and fruits of Fridericia formosa have antiviral activity, being considered of interest for the development of new antiviral drugs. Regarding Ticorea tubiflora, there are no data on its pharmacological properties, however, Campelo et al (2013) demonstrated species from the Rutaceae family, such as Citrus limon, were able to reduce urea, triglyceride and uric acid levels and improve renal function, probably due to the presence of monoterpenes.…”

Section: Discussionmentioning

confidence: 99%

Ethnopharmacological and botanical evaluation of medicinal plants used by Brazilian Amazon Indian community

Meneguelli

Camargo²,

Buccini

et al. 2020

Inter

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Plants have been widely used to treat many diseases, especially by traditional communities as Indians, that can be considered as an important source of empirical knowledge about the medicinal potential of the Brazilian biodiversity. This study aimed to investigate the use of medicinal plants by a particular Amazon-Indian community named Ikólóéhj (Gavião). The data was obtained based on a semi-structured interview and long-term visits along the indigenous area to harvest the botanical material to subsequent identification and storage in herbarium. In the present work, we identify 23 plant species and three morphospecies, distributed into Ferns / Lycophytes and Angiosperms. In addition, we show that leaves (78%), bark (13%) and roots (9%) were used via maceration (49%), topical use (26%), infusion and bath (13%), and decoction (9%). These plants were used to treat pain, diarrhea, malnutrition, parasites infection, wounds, and snakebites. We also observe that the knowledge about medicinal plants is shared to the older members of the community and this information is transmitted orally to the next generations. Thus, the present study contributes to the regrowth and preservation of knowledge about the use of medicinal plants providing important subsidies for understanding of therapeutic properties of Amazonian plants.

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“…Kidney cell LLC-MK2 (ATCC ® CCL-7™) and normal human lung fibroblast cell MRC-5 (ATCC ® CCL-117™) were cultured in Dulbecco's modified Eagle's medium (DMEM, Cultilab, Campinas, SP, Brazil) at 37 °C, in 5% CO 2 atmosphere, supplemented with 5% fetal bovine serum, 50 μg/mL gentamicin, 100 U/mL penicillin and 5 μg/mL amphotericin B (Brandão et al, 2017).…”

Section: Cell Culture and Virusmentioning

confidence: 99%

“…LLC-MK2 and MRC-5 cells were exposed to different concentrations (800 to 0.125 µg/mL) of extracts/ fractions/compounds for 72 h (Brandão et al, 2017). After incubation, cell viability was assessed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT, Merck) assay at a concentration of 2 mg/ mL in phosphate buffered saline (PBS) (Brandão et al, 2017;Twentyman, Luscombe, 1987).…”

Section: Cytotoxicity Assaymentioning

confidence: 99%

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Chromatographic profile of xanthones and flavonoids in the anti-dengue extracts of Fridericia samydoides (Cham.) L.G. Lohmann (Bignoniaceae)

Fonseca

Reis

Pereira

et al. 2022

Braz. J. Pharm. Sci.

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The flavonoids and xanthones present in the ethanol extracts of leaves and stems of Fridericia samydoides showed that anti-dengue activities in vitro were investigated qualitatively by liquid chromatography-ultraviolet-mass spectrometry in series. Nineteen flavones and fifteen xanthones were detected and characterized on the basis of their fragmentation pattern in the positive and negative ion mode tandem mass spectrometry spectra and ultraviolet bands. Acacetin, chrysin, vitexin, isovitexin, orientin, isoorientin, mangiferin, 2'-O-trans-caffeoylmangiferin, 2'-O-trans-coumaroylmangiferin and 2'-O-trans-cinnamoylmangiferin were identified by comparison with authentic samples. The other compounds detected were tentatively assigned by analysis of the spectral data and by comparison with literature reports. In addition, it performed the fractionation of the leaves extract leading to the isolation of mangiferin, isovitexin and isoorientin. All extracts and isolated compounds inhibited the Dengue virus replication cycle with EC 50 less than 25.0 µg/mL for extracts and 272.5, 85.6 and 79.3 µg/mL for mangiferin, isovitexin and isoorientin, respectively.

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Antiviral Activity of Fridericia formosa (Bureau) L. G. Lohmann (Bignoniaceae) Extracts and Constituents

Cited by 13 publications

References 31 publications

Antiviral activity and chemical characterization of Cissus erosa (Vitaceae) ethanol extracts

Antiviral activity and chemical characterization of Cissus erosa (Vitaceae) ethanol extracts

Ethnopharmacological and botanical evaluation of medicinal plants used by Brazilian Amazon Indian community

Chromatographic profile of xanthones and flavonoids in the anti-dengue extracts of Fridericia samydoides (Cham.) L.G. Lohmann (Bignoniaceae)

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