ChemInform Abstract: Synthesis and Antimicrobial Activities of Novel 5‐Substituted Pyrimidin‐2,4,6‐triones.

Abstract

Reaction of barbituric acid (I) with aromatic or heteroaromatic aldehydes gives the corresponding chalcones, which on reduction with NaBH4 yield the desired novel 5‐(het)arylmethylpyrimidinetriones (IV) and (VII).

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“… Antifungal activity: The various extracts of Ailanthus excelsa bark were also screened for antifungal activity [4][5][6] against the fungal strains A. terrus, A. niger and A. flavus. The petroleum ether extract showed less activity against the A. terrus, A. niger and A. flavus organisms when compared with standard drug flucanzole.…”

Antibacterial, Antiurease, and Antioxidant Activities of Some Arylidene Barbiturates

“…Studied compounds 1a [ 38 ], 1b [ 11 ], 1c [ 39 ], 1d [ 11 ], 1e [ 40 ], 1f [ 41 ], and 1g [ 42 ] were prepared by using literature procedures (Scheme 1 ; Table 1 ).

Scheme 1 Studied compounds

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Recent medicinal approaches of novel pyrimidine analogs: A review

“…The enhanced activity may be due to the presence of pyrazole-aldehyde and substituted-pyrimidine scaffold ( Fig. 13 ) [ 43 ].

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“…Benzimidazole [ 51 , 52 ] and Pyrazole derivatives acting as antimicrobial agents [ 53 , 54 ]. Some recent review articles on novel pyrimidine analogs with various pharmacological activities may help the young researcher for designing and developing new active drugs [ [55] , [56] , [57] , [58] , [59] ].

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