ChemInform Abstract: PIROXICAM, A NOVEL ANTI‐INFLAMMATORY AGENT

Eh, Wiseman; Chang, Y. W.; Jg, Lombardino

doi:10.1002/chin.197641380

Cited by 34 publications

(19 citation statements)

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“…The COX-2-selective drugs celecoxib (1 ϫ 25 mg/kg), rofecoxib (1 ϫ 5 mg/kg), and valdecoxib (1 ϫ 5 mg/kg), and the unselective COX inhibitor piroxicam (1 ϫ 5 mg/kg) have been shown to inhibit COX-2-mediated parameters by Ͼ80% in inflammatory (COX-2 mediated) in vivo models (5,33,43). In our preliminary studies, intragastric administration of COX-2 selective inhibitors had no effects on gastric 6-keto-PGF 1␣ synthesis and no significant effects on ulcer healing in COX-2 Ϫ/Ϫ mice.…”

Section: Methodsmentioning

confidence: 99%

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Role of the different isoforms of cyclooxygenase and nitric oxide synthase during gastric ulcer healing in cyclooxygenase-1 and -2 knockout mice

Schmassmann¹,

Zoidl²,

Peskar³

et al. 2006

American Journal of Physiology-Gastrointestinal and Liver Physi

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Section: Methodsmentioning

confidence: 99%

“…The dosing of the drugs was selected on the basis of previous studies (5,10,23,29,33,41,43) and preliminary experiments. Because SC-560 has a shorter half-life than the other COX inhibitors, it was dosed twice daily intragastrically (35).…”

Section: Methodsmentioning

confidence: 99%

Role of the different isoforms of cyclooxygenase and nitric oxide synthase during gastric ulcer healing in cyclooxygenase-1 and -2 knockout mice

Schmassmann¹,

Zoidl²,

Peskar³

et al. 2006

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…Piroxicam is a structurally novel, nonsteroidal anti-inflammatory agent with an enloic group (1). Studies using experimental animals have established that piroxicam is a long-acting, potent inhibitor of the inflammatory response (2,3).…”

mentioning

confidence: 99%

Inhibition of in vitro neutrophil responses to chemotactic factors by piroxicam.

et al. 1984

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Abstract-The effect of piroxicam on polymorphonuclear neutrophils (PMN) functions induced by several stimuli was evaluated in vitro. Preincubation of rabbit or human PMN with piroxicam inhibited the cellular responses elicited by N-formylmethionyl-leucyl-phenylalanine (FMLP) such as superoxide anion (O2-) generation, granule enzyme release and chemotaxis. The effectiveness of piroxicam on each response was superior to those of indomethacin and ibuprofen. Also when either concanavalin A, zymosan-treated serum or ionophore A23187 was used as stimuli, piroxicam inhibited O2-generation of PMN. The inhibitory effect of piroxicam on FM LP-induced O2-generation was dependent on the concentration of stimuli and was reversed, by increasing the extracellular calcium concentration.In addition, piroxicam had no effect on the activity of a chymotrypsin-like esterase, N-acetylphenylalanine-8-naphthyl esterase, isolated from rabbit PMN. These results suggest that at least some of the anti-inflammatory effects of piroxicam may be mediated by affecting PMN functions, and the inhibition of Of generation of PMN by piroxicam may be related to its capacity to modulate the association of calcium with these cells.

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“…There are various reasons to suspect that NSAIDs would impair wound healing, because inflammation is the process whereby cells are recruited to remove necrotic debris and to initiate healing. 16 In the case of NSAID piroxicam, however, there are animal studies indicating that the opposite may be true. 17,18 In a previous study, authors induced injuries of the musculotendinous junction in rats and discovered that treatment with piroxicam had a positive effect on healing and delayed the stress failure of the muscle tendon attachment.…”

Section: Discussionmentioning

confidence: 96%

“…The high potency, long half-life and absence of cardiovascular or central nervous system effects have encouraged clinical trials of piroxicam. 16 Hence the present study was undertaken to compare and evaluate the effect of piroxicam versus diclofenac on wound healing in clean abdominal wounds. There are various reasons to suspect that NSAIDs would impair wound healing, because inflammation is the process whereby cells are recruited to remove necrotic debris and to initiate healing.…”

Section: Discussionmentioning

confidence: 99%

A comparative study of the effect of piroxicam versus diclofenac on wound healing in clean abdominal wounds

Madinur¹,

Tubachi²,

Godhi³

2018

Int Surg J

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Background: The primary function of the skin is to serve as a protective barrier against the environment. The process of wound healing constitutes an array of interrelated and concomitant events. Understanding these processes and various factors affecting these processes continue to expand. The present study was undertaken to compare and evaluate the effect of piroxicam versus diclofenac on wound healing in clean abdominal wounds.Methods: The present one year randomized controlled trial was conducted on all the patients undergoing appendicectomies for uncomplicated appendicitis and uncomplicated inguinal hernia repairs in the Department of Surgery, KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, Belgaum during the period of one year. Based on the thumb rule a total of 60 patients divided into two groups of 30 each were studied. Based on the computer-generated randomization patients were allocated to two groups that is group A (Inj. Piroxicam) and Group B (Inj. Diclofenac).Results: In the present study, males outnumbered females with male to female ratio between of 1.72 to 2:1. The mean age in group A was30.9±7.86 years and in group B it was 30.3±7.97 years. Both the groups that is Group A and B were graded under grade I (Good wound healing) from the POD 3 onwards. Overall the individual score and total scores had no influence of the final grading (outcome) of the wound.Conclusions: Overall, better results were seen on wound healing in patients who received Inj piroxicam with significantly less post-operative redness and edema. However, this did not have significant difference in the final outcome of the grading of the wound.

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ChemInform Abstract: PIROXICAM, A NOVEL ANTI‐INFLAMMATORY AGENT

Cited by 34 publications

References 0 publications

Role of the different isoforms of cyclooxygenase and nitric oxide synthase during gastric ulcer healing in cyclooxygenase-1 and -2 knockout mice

Role of the different isoforms of cyclooxygenase and nitric oxide synthase during gastric ulcer healing in cyclooxygenase-1 and -2 knockout mice

Inhibition of in vitro neutrophil responses to chemotactic factors by piroxicam.

A comparative study of the effect of piroxicam versus diclofenac on wound healing in clean abdominal wounds

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