A comparative study of the effect of piroxicam versus diclofenac on wound healing in clean abdominal wounds

Madinur, Chandrashekar Reddy J.; Tubachi, Prashant; Godhi, Ashok

doi:10.18203/2349-2902.isj20180827

Cited by 4 publications

(2 citation statements)

References 20 publications

(29 reference statements)

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“…al. menemukan terdapat perbaikan luka paska operasi setelah pemberian injeksi diklofenak 75 mg maupun piroxicam 40 mg secara intramuskular selama 3 hari, terutama dalam mengurangi edema dan eritema [11]. Sementara studi oleh Costa et al menggunakan gel diklofenak pada tikus yang dilakukan luka eksisi.…”

Section: Gambar 1 Perbedaan Rerata Jumlah Fibroblas Antar Kelompokunclassified

Efektivitas Ekstrak Spirulina platensis terhadap Jumlah Fibroblas pada Tikus yang Dilakukan Insisi pada Kulitnya

Utami

Misfa

Irenesia

et al. 2023

IJPE

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Fibroblasts play a role in the wound healing process. The active compound content of Spirulina sp. has fibroblastic activity. The use of extracts from S. platensis can play a role in the wound healing process. To analyze the effectiveness of Spirulina platensis extract on the number of fibroblasts in rats that were incised in their skin. This study used a randomized post test only control group design. Forty-eight male Wistar rats were skin incised and infected with S.aureus divided into 4 groups, namely the group given S.platensis extract at a dose of 500 mg/kgBW/day, a dose of 750 mg/kgBW/day, the negative control group was given saline solution and positive control group with diclofenac 20 mg/kgBW orally. The number of fibroblasts was counted on histopathological examination of the wound tissue on the 7th and 14th days covering 5 visual fields. Data analysis was carried out with a one way ANOVA test and continued with the LSD Post Hoc Test. The mean number of fibroblasts on the 7th day in the 500 mg/kgBW/day group, 750 mg/kgBW/day, positive control and negative control was 13.33 ± 3.615; 117.42±3.980; 9.58±2.417; and 4.00 ± 1.761 with p 0.001. The number of fibroblasts on the 14th day in the 500 mg/kgBW/day, 750 mg/kgBW/day group, positive control and negative control was 16.17 ± 3.251; 19.67±1.633; 12.17±2.137; and 8.33 ± 2.317 with p 0.001. The post hoc test found that the number of fibroblasts on day 7 significantly increased in the 500 mg/kgBB/day S. platensis group compared to the positive and negative control groups. While at a dose of 750 mg/kg/day, the number of fibroblasts was higher than the positive and negative control groups after 14 days of treatment.Administration of Spirulina platensis extract at doses of 500 and 750 mg/kg/day significantly increased the number of fibroblasts in the incision wounds of Wistar rats.

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Section: Gambar 1 Perbedaan Rerata Jumlah Fibroblas Antar Kelompokunclassified

Efektivitas Ekstrak Spirulina platensis terhadap Jumlah Fibroblas pada Tikus yang Dilakukan Insisi pada Kulitnya

Utami

Misfa

Irenesia

et al. 2023

IJPE

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“…Stan et al disclosed that the administration of piroxicam improves wound healing following orthopaedic surgery. Furthermore, Madinur et al reported that piroxicam significantly improves wound healing in abdominal wounds with less sign of edema and redness …”

Section: Introductionmentioning

confidence: 99%

A combination therapy of nanoethosomal piroxicam formulation along with iontophoresis as an anti‐inflammatory transdermal delivery system for wound healing

Kazemi

Mombeiny

Tavakol

et al. 2019

International Wound Journal

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Inflammation accounts as one of the major phases in wound healing, while prolonged and chronic inflammation may lead to adverse pathological conditions. Therefore, transdermal delivery of nonsteroidal anti‐inflammatory (NSAIDs) such as encapsulated piroxicam into a nanocarrier seems to be promising. For the first time, a nanoethosomal piroxicam of <200 nm was prepared and combined with iontophoresis. Results showed that there was a critical point at the concentration of 5 mg lecithin with the smallest particle size. Besides, lecithin concentration had direct and inverse linear relationships with turbidity and pH of nanocarriers, respectively. Moreover, as there was no linear relationship between the lecithin concentration and particle size, the effect of lecithin concentration was dominant on turbidity compared with particle size. It seems that a pH higher than 5.5 disturbed the linear relationship of pH and entrapment efficacy percentage (EE%) while at the pH range of 4 to 5.5, the relationship was linear and EE% gradually decreased with increasing pH. These data showed that an optimised nanocarrier with special physicochemical properties is dominant to the just particle size. Besides, ex vivo permeation studies in rat skin showed that there was no significant difference between the permeation of free drug and ethosomal ones. However, iontophoresis significantly enhanced ethosomal piroxicam permeation compared with the free drug. Overall, these data emphasise the superiority of iontophoresis for the transdermal delivery of nanoethosomal medications while nanoethosomal delivery without iontophoresis did not show significant transdermal potential. To sum up, transdermal nanoethosomal piroxicam along with iontophoresis seems to be promising in wound healing.

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Piroxicam

Mostafa¹,

Al-Dosseri²,

Al-Badr³

2020

Profiles of Drug Substances, Excipients and Related Methodology

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A comparative study of the effect of piroxicam versus diclofenac on wound healing in clean abdominal wounds

Cited by 4 publications

References 20 publications

Efektivitas Ekstrak Spirulina platensis terhadap Jumlah Fibroblas pada Tikus yang Dilakukan Insisi pada Kulitnya

Efektivitas Ekstrak Spirulina platensis terhadap Jumlah Fibroblas pada Tikus yang Dilakukan Insisi pada Kulitnya

A combination therapy of nanoethosomal piroxicam formulation along with iontophoresis as an anti‐inflammatory transdermal delivery system for wound healing

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