ChemInform Abstract: Phytochemical Investigation of Labdane Diterpenes from the Rhizomes of Hedychium spicatum and Their Cytotoxic Activity.

Reddy, P. Prabhakar; Rao, R. Ranga; Shashidhar, J.; Sastry, B. S.; Rao, J. Madhusudana; Babu, K. Suresh

doi:10.1002/chin.201009184

Cited by 6 publications

(10 citation statements)

References 1 publication

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“…Li and his colleagues reported the a-glucosidase inhibitory effect of tinosposinensides A-C (118-120) with the IC 50 values ranging from 2.9 to 3.8 mM (Li et al 2007). Hedychenone (215), yunnacacoronarin D (217) and 7-hydroxy hedychenone (220) were also reported with a-glucosidase inhibitory effect with inhibition rate from 13.5-55.6 % at 100 lg/mL (Prabhakar Reddy et al 2009). …”

Section: Receptor Binding Affinitymentioning

confidence: 92%

Naturally occurring furanoditerpenoids: distribution, chemistry and their pharmacological activities

et al. 2016

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Furanoditerpenoids are a special group of diterpenoids composing of one or more furan rings, which are rarely found in nature. This review aims to survey the various naturally occurring furanoditerpenoids and their pharmacological activities. A fairly large number of furanoditerpenoids have been reported from the families Euphorbiaceae, Fabaceae and Lamiaceae, and a few ones from the families Asteraceae, Codoniaceae, Dioscoreaceae, Fossombroniaceae, Jamesoniellaceae, Meliaceae, Menispermaceae, Olacaceae, Psathyrellaceae, Sapindaceae and Scapaniaceae. Their distribution correlates strongly with the taxonomic divisions. Most of these plants are widely used in traditional medicines, and furanoditerpenoids have therefore been disclosed with a wide range of bioactivities including anti-cancer, antiinflammation and anti-microorganism. To structure this review, the furanoditerpenoids were classified into seven types, including clerodane-type (Type I), labdane-type (Type II), cassane-type (Type III), abietane-type (Type IV), spongian-type (Type V), prenylbisabolane-type (Type VI) and miscellaneous type (Type VII). On the basis of 170 references, this review covers the distribution, phytochemistry, synthesis and pharmacological activities of furanoditerpenoids, describing 444 compounds. The information provided in this review might shed light on further research and development of furanoditerpenoids as potential therapeutic agents.

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Section: Receptor Binding Affinitymentioning

confidence: 92%

Naturally occurring furanoditerpenoids: distribution, chemistry and their pharmacological activities

et al. 2016

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“…Whereas the chemical constituents from the rhizomes of H. spicatumled to the isolation of two new labdane-type diterpenes which were characterized as 7-hydroxy hedichinal and spicatanoic acid and six known compounds thatwereyunnacoronarin D; coronarin E; 8(12) drimene; 4-methoxy ethyl cinnamate; ethyl cinnamate and chrysin 29 . In addition, another labdane-type diterpenes was successfully isolated from CHCl 3 extract of H. Spicatum.…”

Section: Diterpenesmentioning

confidence: 99%

“…Among the test compound, 7-hydroxy hedichinal showed potent activity and spicatanoic acid exhibited moderate activity 29 . In addition, in vitro cytotoxicity test of the isolates from CHCl 3 extract of H. spicatum were investigated against Colo-205, A-431, MCF-7, A-549 and CHO cell lines.…”

Section: Cytotoxicitymentioning

confidence: 99%

Botanical, Phytochemical and Pharmacological Properties of Hedychium (Zingiberaceae) – A Review

2014

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Zingiberaceae is one of the most widely distributed plants in tropic and subtropic area, about 19 genus and 375 species weredistributed in Indonesia. Based on empirical data, some of the plants were used traditionally to treat various diseases. Nowadays, Zingiberaceae plants are extensively studied for their phytochemistry and pharmacological properties included genus Hedychium. The various bioactive compounds were isolated from these plants and they were known to have the pharmacological effect. This review showed that Hedychium plants were prospective as a natural product medicine.

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“…Results of the MTT assay carried out with the methanol extracts of H. spicatum upon HeLa cervical cancer cells presented an IC 50 value of 48.77 ppm hinting at the plant to be a promising anticancer drug aspirant [105] . Reddy et al [106] isolated two new labdane diterpenes from the plant. Compound 1 had significant cytotoxic role upon Colo 205, CHO, MCF-7 and A459 cell lines.…”

Section: Roscoea Purpureamentioning

confidence: 99%

The Ginger Prophecy; A Review of the Underexplored Genus, Hedychium against Cancer

Verma¹,

Kundu²

2020

ijps

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ChemInform Abstract: Phytochemical Investigation of Labdane Diterpenes from the Rhizomes of Hedychium spicatum and Their Cytotoxic Activity.

Cited by 6 publications

References 1 publication

Naturally occurring furanoditerpenoids: distribution, chemistry and their pharmacological activities

Naturally occurring furanoditerpenoids: distribution, chemistry and their pharmacological activities

Botanical, Phytochemical and Pharmacological Properties of Hedychium (Zingiberaceae) – A Review

The Ginger Prophecy; A Review of the Underexplored Genus, Hedychium against Cancer

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