ChemInform Abstract: Peloruside A: A Potent Cytotoxic Macrolide Isolated from the New Zealand Marine Sponge Mycale sp.

Abstract

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Mutations in the β-tubulin binding site for peloruside A confer resistance by targeting a cleft significant in side chain binding

“…6,7 While it shares with paclitaxel (Taxol ® ) the ability to stabilize MT in cells and induce polymerization of purified tubulin, it does not bind to the paclitaxel site. This conclusion was reached due to evidence that peloruside A does not displace paclitaxel from MT, and does act synergistically with paclitaxel in cell-based assays.…”

Modernization of traditional Chinese medicine

“…Pelorusides: Peloruside A is a polyoxygenated 16-membered macrolide of marine origin. In 2000, it was isolated as a secondary metabolite from the New Zealand marine sponge Mycale hentscheli [77]. Its 16-membered macrolide ring is similar to that of the epothilones.…”

Docking and molecular dynamics studies of the binding between Peloruside A and tubulin

“…Peloruside A (PLA) (see Figure 1), characterized by a polyoxygenated pyranose ring containing 16-membered macrolide, was first isolated in 1999 from New Zealand marine sponge Mycale hentscheli, and it had potent growth inhibition against P388 murine leukemic cells 5 . PLA was further found to be a microtubule-stabilizing agent and to have potent antimitotic activity, making cells block in G2/M phase and apoptosis 6,7 .…”