Modernization of traditional Chinese medicine

Guo, De‐An; Lü, Aiping; Liu, Liang

doi:10.1016/j.jep.2012.05.001

Cited by 33 publications

(23 citation statements)

References 14 publications

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“…Research should not be viewed as a means to discover new compounds, but rather, should be seen as an absolute need to develop the most promising plant therapies into either unmodified natural products (crude extracts), semi-refined products (fractions/sub-fractions or recombinants of fractions), and/or pure compounds and compound formulas [ 4 , 8 , 28 , 29 , 30 ]. Semi-processed products can be cheaper and have concentrated active components without constituents with adverse or toxic effects.…”

Section: The Potential For New Drugs To Treat Pain and Gastrointesmentioning

confidence: 99%

“…Ethanol and other organic solvents are rarely used, however, it is not uncommon for herbalists to prepare extracts using local brews. Semi-refined and highly refined preparations, similar to compound formulas used in traditional Chinese medicine [ 7 , 8 ], have not been reported. Typically, in TAHM, animal patients are treated at home or in grazing areas.…”

Section: Introductionmentioning

confidence: 99%

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Ethnopharmacological Survey of Plants Used in the Traditional Treatment of Gastrointestinal Pain, Inflammation and Diarrhea in Africa: Future Perspectives for Integration into Modern Medicine

Stark

Mtui

Balemba

2013

Animals

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Simple SummaryThis review provides an inventory of numerous plant species used as traditional remedies for pain and diarrhea in Africa. Africa can emulate advances in traditional Chinese medicine through research, commercialization, teaching traditional medicine in medical schools, and incorporating botanical products in treating veterinary and human patients. Prioritized research of plant species with proven folklore in treating pain and diarrhea using high throughput screening to identify and test bioactive compounds to verify their effectiveness, mechanisms of action and safety and translational research are needed to facilitate these advances and the integration of traditional African botanical preparations for treating pain and gastrointestinal disorders into western medicine.AbstractThere is a growing need to find the most appropriate and effective treatment options for a variety of painful syndromes, including conditions affecting the gastrointestinal tract, for treating both veterinary and human patients. The most successful regimen may come through integrated therapies including combining current and novel western drugs with acupuncture and botanical therapies or their derivatives. There is an extensive history and use of plants in African traditional medicine. In this review, we have highlighted botanical remedies used for treatment of pain, diarrheas and inflammation in traditional veterinary and human health care in Africa. These preparations are promising sources of new compounds comprised of flavonoids, bioflavanones, xanthones, terpenoids, sterols and glycosides as well as compound formulas and supplements for future use in multimodal treatment approaches to chronic pain, gastrointestinal disorders and inflammation. The advancement of plant therapies and their derivative compounds will require the identification and validation of compounds having specific anti-nociceptive neuromodulatory and/or anti-inflammatory effects. In particular, there is need for the identification of the presence of compounds that affect purinergic, GABA, glutamate, TRP, opioid and cannabinoid receptors, serotonergic and chloride channel systems through bioactivity-guided, high-throughput screening and biotesting. This will create new frontiers for obtaining novel compounds and herbal supplements to relieve pain and gastrointestinal disorders, and suppress inflammation.

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Section: The Potential For New Drugs To Treat Pain and Gastrointesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ethnopharmacological Survey of Plants Used in the Traditional Treatment of Gastrointestinal Pain, Inflammation and Diarrhea in Africa: Future Perspectives for Integration into Modern Medicine

Stark

Mtui

Balemba

2013

Animals

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“…The current regime for the management of inflammation includes the administration of the non-steroidal anti-inflammatory drugs (NSAIDs), glucocorticoids and opioids. These therapies suffer from the drawback of long-term toxicity and variation in clinical efficacy [3]. Syringic acid (SA) (4-hydroxy-3,5-dimethoxybenzoic acid) is a polyphenolic compound ( fig.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Anti-Inflammatory Activity of Syringic Acid

Chanda

Juvekar

2018

Int J Pharm Pharm Sci

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Objective: The present study was carried out to investigate the in vitro anti-inflammatory activity of syringic acid (SA). Methods: SA was tested for it's in vitro anti-inflammatory activity at different concentrations in protein denaturation, proteinase inhibition and human red blood cell (HRBC) membrane stabilization assay. The reference drugs used were aspirin and diclofenac sodium. Results: SA showed concentration-dependent inhibition of protein denaturation and proteinase activity with a half-maximal inhibitory concentration (IC50) value of 49.38±0.56 µg/ml and 53.73±0.27 µg/ml respectively. Heat-induced haemolysis was inhibited by SA with an IC50 value of 57.13±0.24 µg/ml. SA also inhibited the hypotonicity-induced haemolysis (IC50 value of 53.87±0.72 µg/ml). Conclusion: From the present study, we can conclude that SA possesses appreciable anti-inflammatory effect against denaturation of proteins, proteinase activity, and human red blood membrane stabilization assays. Further studies are required for determining the possible mechanisms behind its anti-inflammatory action.

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“…With TCM knowledge accumulated for thousands of years, classic techniques to identify syndrome include observation, listening, questioning, and pulse analysis [2], which mostly depend on empirical opinions of TCM doctors and subjective feelings of patients. Hence, such inevitable characteristics block the process of TCM modernization to drive TCM into an evidence-base medicine [4]. For example, when a patient tells a TCM doctor how he feels, what he describes can hardly be measured quantitatively; when a doctor differentiates the syndromes a patient may belong to, the diagnosis is made based on the doctor's experience and may not acquire approval of other TCM doctors.…”

Section: Introductionmentioning

confidence: 99%

A Network-Based Approach to Investigate the Pattern of Syndrome in Depression

Song

Deng

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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In Traditional Chinese Medicine theory, syndrome is essential to diagnose diseases and treat patients, and symptom is the foundation of syndrome differentiation. Thus the combination and interaction between symptoms represent the pattern of syndrome at phenotypic level, which can be modeled and analyzed using complex network. At first, we collected inquiry information of 364 depression patients from 2007 to 2009. Next, we learned classification models for 7 syndromes in depression using naïve Bayes, Bayes network, support vector machine (SVM), and C4.5. Among them, SVM achieves the highest accuracies larger than 0.9 except for Yin deficiency. Besides, Bayes network outperforms naïve Bayes for all 7 syndromes. Then key symptoms for each syndrome were selected using Fisher's score. Based on these key symptoms, symptom networks for 7 syndromes as well as a global network for depression were constructed through weighted mutual information. Finally, we employed permutation test to discover dynamic symptom interactions, in order to investigate the difference between syndromes from the perspective of symptom network. As a result, significant dynamic interactions were quite different for 7 syndromes. Therefore, symptom networks could facilitate our understanding of the pattern of syndrome and further the improvement of syndrome differentiation in depression.

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Modernization of traditional Chinese medicine

Cited by 33 publications

References 14 publications

Ethnopharmacological Survey of Plants Used in the Traditional Treatment of Gastrointestinal Pain, Inflammation and Diarrhea in Africa: Future Perspectives for Integration into Modern Medicine

Ethnopharmacological Survey of Plants Used in the Traditional Treatment of Gastrointestinal Pain, Inflammation and Diarrhea in Africa: Future Perspectives for Integration into Modern Medicine

In Vitro Anti-Inflammatory Activity of Syringic Acid

A Network-Based Approach to Investigate the Pattern of Syndrome in Depression

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