ChemInform Abstract: Oxidation of Chemical Compounds: Kinetics and Mechanistic Approach

Gour, Shalini; Dhobal, B. S.; Hussain, Sayyed; Farooqui, Mazahar

doi:10.1002/chin.201214259

Cited by 2 publications

(2 citation statements)

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“…Chemical kinetics is concerned with understanding the rates of chemical reaction, the speed at which chemical species can transform into new substances by breaking and reforming the chemical bonds (Srgoura et al, 2011). It can reasonably guide us to control the reaction conditions and improve the reaction rate, to increase the production of chemical products, and also guide us to learn how to suppress or slow down the reaction rate of side reactions to reduce the consumption of raw materials (Zhang et al, 2020;Keith, 2012).…”

Section: Introductionmentioning

confidence: 99%

Mechanism and Kinetics Studies of Oxidation of the Pharmaceutical Drug Amlodipine Besylate by N-bromosuccinimide in Aqueous Acidic Medium

S¹,

Shastry²

2020

ijrps

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The oxidation of the pharmaceutical drug Amlodipine besylate [AML] by N-Bromosuccinimide [NBS] was investigated aqueous acidic medium under pseudo-first-order condition. The experimental results indicated that the reaction exhibits first-order concerning N-bromosuccinimide, fractional-order concerning [AML] and sulphuric acid [H2SO4]. There was no substantial effect on the rate of the reaction with KNO3. The reaction stoichiometry shows one mole of amlodipine besylate consumes one mole of n-bromosuccinimide. The effect of temperature on the reaction rate was studied, and the activation parameters (Ea, ∆ G, ∆ H and ∆ S) are calculated and tabulated. LC-MS technique was used to identify the oxidation product of amlodipine besylate. Based on experimental results, a mechanism is proposed, and constants K1, K2 and k3 involved in the mechanism were evaluated. The observed rate constant values and the experimental value calculated by substituting the value of k3= 4.0 × 10−3 s -1, K2 = 1272 moldm-3s-1andK1= 1.96 x 10-6 in the rate equation is in good accordance with each other.

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Section: Introductionmentioning

confidence: 99%

Mechanism and Kinetics Studies of Oxidation of the Pharmaceutical Drug Amlodipine Besylate by N-bromosuccinimide in Aqueous Acidic Medium

S¹,

Shastry²

2020

ijrps

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“…Veeraiah, M.K et al, 22 29 , have shown the oxidation of drugs by using CAT as oxidising agents in various methods. Literature shows oxidation of methyl vinyl ketone and isopropyl methyl ketone, ketoglutaric acids, formic acids, substituted transcinnamic acids, methionine, substituted and unsubstituted imidazole and benzimidazoles done by using CAT as an oxidising agent 30 .…”

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confidence: 99%

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2017

IJPSR

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ABSTRACT:The kinetics and mechanism of oxidation of Phenylephrine (PHE) by Chloramine-T (CAT) in acid media have been investigated by spectroscopic technique at the temperature of 298 K. It is found that the reaction is of first order with respect to PHE, fractional order with respect to CAT & inverse order with respect to H + . The reaction rate remained unchanged with the variation of ionic strength of the medium indicating that the non ionic species are involved in the rate determining step. The rate of reaction decreases with increase in concentration of dielectric constant. Addition of chloride ions had no effect on rate of reaction. The stoichiometric ratio was found to be 1:1(PHE: CAT) ratio. The major oxidation product of PHE has been identified by an UV, Cyclic voltammetry (CV), IR, H 1 NMR and Mass spectroscopy. On the basis of the experimental results, a suitable mechanism has been proposed. The rate constants of the rate-determining step together with the activation parameters were evaluated and also thermodynamic quantities were determined.

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ChemInform Abstract: Oxidation of Chemical Compounds: Kinetics and Mechanistic Approach

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Cited by 2 publications

References 3 publications

Mechanism and Kinetics Studies of Oxidation of the Pharmaceutical Drug Amlodipine Besylate by N-bromosuccinimide in Aqueous Acidic Medium

Mechanism and Kinetics Studies of Oxidation of the Pharmaceutical Drug Amlodipine Besylate by N-bromosuccinimide in Aqueous Acidic Medium

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