ChemInform Abstract: NONSTEROIDAL ANTIINFLAMMATORY AGENTS, X: ANTIPHLOGISTIC PYRAZOLE DERIVATIVES, II

Biere, H.; Boettcher, I.; Kapp, Joachim‐Friedrich

doi:10.1002/chin.198345192

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Dealkylation Of Esters By Me 3 Six1

Introduction1

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2017

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Cited by 2 publications

(2 citation statements)

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“…Tetralkyl 1-hydroxy-1,1-bisphosphonates can be converted into tetrakis(trimethylsilyl) esters on treatment with bromotrimethylsilane [64] or iodotrimethylsilane [65,66], also a known behavior of dialkyl phosphonates [67] or dialkyl acylphosphonates [68]. Alternatively, tetrakis(trimethylsilyl) esters can be obtained by using chlorotrimethylsilane with sodium iodide [69].…”

Section: Dealkylation Of Esters By Me 3 Sixmentioning

confidence: 99%

Synthesis of 1-hydroxy-1,1-bisphosphonates

Lecouvey

Leroux

2000

Heteroatom Chem.

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Section: Dealkylation Of Esters By Me 3 Sixmentioning

confidence: 99%

Synthesis of 1-hydroxy-1,1-bisphosphonates

Lecouvey

Leroux

2000

Heteroatom Chem.

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“…Our continuous studies have demonstrated the utilization of carbohydrates specially L-ascorbic acid and its analogs in the synthesis of heterocycles including pyrazoles, triazoles, imidazoles and isoxazolines [1][2][3][4][5]. The observation that triazole and pyrazole derivatives are biologically active compounds [6][7][8][9][10] specially as insecticides and antiflamatory has promoted the extension of our study to synthesize a new series of this class of compounds in the hope of producing more effective chemotherapeutic agents.…”

Section: Introductionmentioning

confidence: 99%

Some New Heterocycles from the Reaction of 4-Carboxaldehyde-2-Phenyl-2H-1,2,3-Triazole Malononitrile

Sekily¹,

Mancy²,

El‐Ghanam³

et al. 2017

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Reaction of 4-carboxaldehyde-2-phenyl-2H-1,2,3-triazole 1 with malononitrile in presence of piperidine afforded the triazolomalonitrile 2 which on treatment with hydrazine hydrate, gave 3-amino-5-(2-phenyl-2H-1,2,3-triazol-4-yl)-4,5-dihydro-1-H-pyrazole-4-carbonitrile 3 and with hydroxylamine, gave 5-amino-3-(2-phenyl-2H-1,2,3-triazol-4-yl)-2,3-dihydroisoxazole-4-carbonitrile 4, and with thiourea, gave 2,4-diamino-6-(2-phenyl-2H-1,2,3-triazol-4-yl)-6H-1,3-thiazine-5-carbonitrile 5. Similarly, reaction of 2 with ethanol amine, gave 2-amino-4-(2-phenyl-2H-1,2,3-triazol-4-yl)nicotinonitrile 6, and with thiosemicarbazide, gave 4-amino-2-hydrazinyl-6-(2-phnyl-2H-1,2,3-triazol-4-yl)-6H-1,3-thiazine-carbonitrile 7. Similary reaction of 2 with cyclopentanone gave, 2-amino-4-(2-phenyl-2H-1,2,3-triazol-4-yl)-4,5,6,7-tetrahydrocyclopenta [6] pyran-3-carbonitrile 8. In addition, reaction of 1 with hydrazine hydrate, gave the 4 hydrazone which on treatment with another mole of 1 gave 10 and with 3-carboxaldehyde-1-phenyl-4,5-pyrazolinedione 4 phenylhydrazone gave compound 11.

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ChemInform Abstract: NONSTEROIDAL ANTIINFLAMMATORY AGENTS, X: ANTIPHLOGISTIC PYRAZOLE DERIVATIVES, II

Abstract: Pyrazolylalkylcarbonsäure‐Derivate (II) werden ausgehend vom Ester (I) nach literaturbekannten Verfahren hergestellt und auf entzündungshemmende Wirksamkeit getestet.

Cited by 2 publications

References 1 publication

Synthesis of 1-hydroxy-1,1-bisphosphonates

Synthesis of 1-hydroxy-1,1-bisphosphonates

Some New Heterocycles from the Reaction of 4-Carboxaldehyde-2-Phenyl-2H-1,2,3-Triazole Malononitrile

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