ChemInform Abstract: New Bromopyrrole Alkaloid from the Marine Sponge Agelas wiedenmayeri.

Abstract

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Tracking of fast moving neuronal vesicles with ageladine A

“…Other brominated pyrrole alkaloids, especially some of the dimeric molecules, are known to have antibiotic, antiparasitic and cytotoxic effects [9,14,29], interact with membrane ion channel function [30] and therefore ionic trans-membrane transport processes [11] and inhibit cell motility in a variety of cancer cell lines [31]. As sensory and olfactory neurones of predators are primarily exposed to sponge compounds [11] and are equipped with numerous ion channel and cellular signal chains it seems plausible that these alkaloids serve as feeding deterrents as described by several authors [6,7,8].…”

“…All experiments were carried out one or two days after plating cells in collagen coated dishes (see above). The physiological bath solution for measurement of in-and out-ward currents comprised: 125 mM NaCl, 2.5 mM KCl, 1 mM Ageladine A Ageladine A was synthesised from 2-aminohistamine [16] or obtained from the sponge Agelas wiedenmayeri [14].…”

“…Subsequently, we have isolated the same compound from a Caribbean sponge Agelas wiedenmayeri [14]. Ageladine A has been reported to be a moderate inhibitor of matrix metalloproteases and to be intensely fluorescent [13].…”

Bioactive Secondary Metabolites from the Marine Sponge Genus Agelas

“…Chemical investigation of Agelas wiedenmayeri from Florida Keys afforded one new pyrrole derivative, 4-bromopyrrole-2-carboxyhomoarginine ( 202 ) ( Figure 24 ), which might be alternatively a biosynthetic precursor of hymenidin/oroidin-related alkaloids [ 84 ].…”

The Alkaloid Ageladine A, Originally Isolated from Marine Sponges, Used for pH-Sensitive Imaging of Transparent Marine Animals

“…The first source of Ageladine A was the marine sponge Agelas nakamurai and later it was isolated also from the sponge Agelas wiedenmayeri [3]. Methods for synthesizing Ageladine A were published in 2006 [4,5] and improved in the following years [6,7].…”