Bioactive Secondary Metabolites from the Marine Sponge Genus Agelas

Zhang, Huawei; Dong, Menglian; Chen, Jianwei; Wang, Hong; Tenney, Karen; Crews, Phillip

doi:10.3390/md15110351

Cited by 36 publications

(36 citation statements)

References 120 publications

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“…(Figure 7) (Table 3). Among them, the following halimane families can be found: ent-halim-1 10 (Figure 7) All of them were isolated from sponges of the genus Agellas, except for asmarine I, 28, and asmarine J, 29, which were isolated from Raspailia sp [43]. These compounds show antibacterial, antifungal, antimalarial, and cytotoxic activities, inhibition of adenosine transfer into rabbit erythrocytes and Ca 2+ channel antagonistic action and α1 adrenergic blockade, among others.…”

Section: Marine Simple Halimanes 8-14mentioning

confidence: 99%

Antibacterial Natural Halimanes: Potential Source of Novel Antibiofilm Agents

et al. 2020

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The development of new agents against bacteria is an urgent necessity for human beings. The structured colony of bacterial cells, called the biofilm, is used to defend themselves from biocide attacks. For this reason, it is necessary to know their structures, develop new agents to eliminate them and to develop new procedures that allow an early diagnosis, by using biomarkers. Among natural products, some derivatives of diterpenes with halimane skeleton show antibacterial activity. Some halimanes have been isolated from marine organisms, structurally related with halimanes isolated from Mycobacterium tuberculosis. These halimanes are being evaluated as virulence factors and as tuberculosis biomarkers, this disease being one of the major causes of mortality and morbidity. In this work, the antibacterial halimanes will be reviewed, with their structural characteristics, activities, sources and the synthesis known until now.

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Section: Marine Simple Halimanes 8-14mentioning

confidence: 99%

Antibacterial Natural Halimanes: Potential Source of Novel Antibiofilm Agents

et al. 2020

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“…72 Recently there has been enormous interest in the bioactivities of diterpenyl purines. 73 From Agelas sp., 74 nine halimane purines have been isolated that show antibacterial, antifungal, antimalarial, cytotoxic activities, inhibition of adenosine transfer rabbit erythrocytes and Ca 2+ channel antagonistic action and a 1 adrenergic blockade, among others. Some of these compounds possess antifouling activity against macroalgae.…”

Section: Biological Activities Of Halimanesmentioning

confidence: 99%

Halimane diterpenoids: sources, structures, nomenclature and biological activities

et al. 2018

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Covering: 1970 to 2017 Diterpenes with a halimane skeleton constitute a small group of natural products that can be biogenetically considered as being between labdane and clerodane diterpenoids. Some of these compounds show biological activities, such as antitumour, mosquito repellency, germination inhibition and antimicrobial, as well as being biomarkers for tuberculosis. To the best of our knowledge, there are no reviews on these compounds. In this review, halimane skeleton diterpenoids are classified according to their biogenetic origin, characterization and/or the enzymes involved in their biosynthesis. Herein, a review of their synthesis or synthetic approaches is communicated.

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“…), the depths of the ocean (Zhang et al . ) and everyday sites (e.g. Swab and Send) and the Small World Initiative.…”

Section: Methodsmentioning

confidence: 99%

“…In an introduction, visitors were shown a timeline adapted from Lewis (2013) revealing intensive activity over a relatively short time period when the majority of antibiotics were discovered and mass produced. Now there are many initiatives whose aim is to identify potential new agents, with samples being taken from different environments, for example, caves (Pawlowski et al 2016), the depths of the ocean (Zhang et al 2017) and everyday sites (e.g. Swab and Send) and the Small World Initiative.…”

Section: Can We Find New Antibiotics?mentioning

confidence: 99%