ChemInform Abstract: MALONYL AND SUCCINYL DICYCLOHEXYLAMIDES AND ALLIED COMPOUNDS AS POTENTIAL ANTIINFLAMMATORY AGENTS

Abstract

G′? Die Amide (I)‐(III) wurden durch Umsetzung entsprechender Säurechloride mit Cyclohexylamin, das Bisamin (IV) durch Reaktion von Cyclohexylamin mit 1,3‐Dibrom‐propan erhalten.

1,2,6-Thiadiazin-3,5(2H,6H)-dione 1,1-dioxide derivatives: crystal structure, physico-chemical and biological properties

“…The effect of an SO2 group on 13C nInr chemical shift can be evaluated by comparing the data of thiadiazine derivatives 1, 2, 3, and those of phenylbutazone (4). Thus, the signal belonging to the equivalent C3 and C5 is shifted to lower field (-5 ppm) in phenylbutazone, whilst the C4 signal is shifted to higher field (-6 ppm) as can be seen from the data of 3 and 4.…”

“…Compound 3 can be considered as pyrazolidindione 4 in which an SO2 group has been introduced between the two nitrogen atoms. Thiadiazine derivatives 1 and 2 have been chosen because the cyclohexyl moiety seems to be useful for inducing antiinflammatory activity (4)(5)(6). Thus, whilst 1,2-dicyclohexyl pyrazole derivatives have shown some activity (7), the corresponding cyclopentyl compounds turned out to be inactive (8).…”