1,2,6-Thiadiazin-3,5(2<i>H</i>,6<i>H</i>)-dione 1,1-dioxide derivatives: crystal structure, physico-chemical and biological properties

Goya, Pilar; Nieves, R.; Ochoa, Carmen; Rodellas, C.; Martı́nez-Ripoll, M.; García-Blanco, S.

doi:10.1139/v87-049

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1988

2023

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Cited by 13 publications

(1 citation statement)

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“…Leur caractkre non aromatique s'accorde avec les structures pliCes qui sont dtcrites dans la litttrature (1)(2)(3)(4)(5)(6)(7)(8). Pour ce qui concerne plus particulihement les dtrivCs de la 2H-thiadiazine-1,2,6 dioxyde-1 , 1 , plusieurs activitts biologiques differentes ont t t t mentionnCes.…”

Section: Introductionunclassified

Étude structurale de l'amino-5 dibenzyl-4,4 one-3 2H-thiadiazine-1,2,6 dioxyde-1,1

Brouant¹,

Barbe²,

Goya³

et al. 1988

Can. J. Chem.

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Section: Introductionunclassified

Étude structurale de l'amino-5 dibenzyl-4,4 one-3 2H-thiadiazine-1,2,6 dioxyde-1,1

Brouant¹,

Barbe²,

Goya³

et al. 1988

Can. J. Chem.

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Theoretical and experimental analysis of properties in heterocycles containing the aminosulphonylamino moiety

Alkorta

García‐Gómez

Páez

et al. 1996

J. Phys. Org. Chem.

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A theoretical and experimental analysis of the geometric and electronic properties of compounds containing the aminosulphonylamino moiety was carried out. The theoretical properties were calculated using molecular orbital a b initb methods at the Hartree-Fock (HF) and second order Moller-Plesset (MP2) levels of theory, local density functional (LDF) ab initio methods and the semi-ab initio method,

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Synthesis and Antiprotozoal Properties of 1,2,6‐Thiadiazine 1,1‐Dioxide Derivatives

Herrero¹,

Ochoa²,

Atienza³

et al. 1992

Archiv der Pharmazie

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The synthesis and spectroscopical data of 1,2,6-thiadiazine 1,1-dioxides, designed as antiprotozoal agents, are reported. The in vitro trichomonacidal and trypanocidal activities of new compounds and their precursors were evaluated against Trichomonas vaginalis and Trypanosoma cruzi. The chemoprophylactic activity on mice treated with blood infected with T. cruzi and their mortality percentage were tested. Compounds 2 and 8b show a higher chemoprophylactic activity and lower mortality percentage than Nifurtimox used as reference drug.

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1,2,6-Thiadiazin-3,5(2H,6H)-dione 1,1-dioxide derivatives: crystal structure, physico-chemical and biological properties

Cited by 13 publications

References 17 publications

Étude structurale de l'amino-5 dibenzyl-4,4 one-3 2H-thiadiazine-1,2,6 dioxyde-1,1

Étude structurale de l'amino-5 dibenzyl-4,4 one-3 2H-thiadiazine-1,2,6 dioxyde-1,1

Theoretical and experimental analysis of properties in heterocycles containing the aminosulphonylamino moiety

Synthesis and Antiprotozoal Properties of 1,2,6‐Thiadiazine 1,1‐Dioxide Derivatives

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