ChemInform Abstract: ′CASCADE′‐ AND ′NONSKID‐CHAIN‐LIKE′ SYNTHESES OF MOLECULAR CAVITY TOPOLOGIES

Buhleier, E.; Wehner, W.; Voegtle, F.

doi:10.1002/chin.197825228

Cited by 52 publications

(12 citation statements)

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“…Synthesis of the Fréchet dendrons with N,Osalicylaldimine ligands (1)(2)(3) or Fréchet organometallic dendrons with Rh(I) N,O-salicylaldimine complexes at the focal point (4-9).…”

Section: Methodsmentioning

confidence: 99%

“…The Fréchet dendrons with N,O-salicylaldimine ligands at the focal point (1)(2)(3) were dissolved in a minimum amount of dichloromethane. The deprotonation of the phenolic proton was accomplished using excess equivalents of NEt3.…”

Section: Synthesis and Characterisation Of Fréchet Dendrons With Nosa...mentioning

confidence: 99%

“…The inception of dendrimers in the 1970's has stimulated interest into the study and synthesis of these versatile structures. 1 The introduction of metals into dendrimers allows for a plethora of applications, which are predominantly used in catalytic, sensing and biomedical spheres. 2 This metal-dendrimer relationship offers a niche of new materials, which emanates from the synergistic effect between a metal and dendrimer.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and hydroformylation evaluation of Fréchet-type organometallic dendrons with N,O-salicylaldimine Rh(i) complexes at the focal point

et al. 2018

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A series of organometallic dendrons containing N,O-salicylaldimine entities at the focal point were synthesised by reacting the N,O-salicylaldimine-functionalised Fréchet dendrons (G0, G1 and G2) with a [Rh(μ-Cl)(η2:η2-COD)]2 dimer to yield the corresponding Rh(COD) [COD = cyclooctadiene] complexes. These Rh(COD) complexes were exposed to an atmosphere of CO to yield a new class of rhodium carbonyl organometallic dendrons with Rh(CO)2 units at the focal point. All the compounds were characterised using standard spectroscopic and analytical techniques, these include nuclear magnetic resonance, infrared spectroscopy, mass spectrometry and single-crystal X-ray diffraction for compounds 1, 4 and 7. All of the complexes were evaluated in the hydroformylation of 1-octene, with excellent conversion and chemoselectivity towards aldehydes. The G0-(CO)2 catalyst precursor (7) was active in the hydroformylation of 1-octene, styrene, 7-tetradecene, methyl oleate, triolein, d-limonene and R-citronellal. The conversion and chemoselectivity towards aldehydes for 7-tetradecene, methyl oleate, triolein and d-limonene were promising. Across a particular dendron series, an increase in chemoselectivity was observed due to the dendritic effect. Mercury drop tests were performed for the G0-analogues and these confirm that the hydroformylation can be attributed to a combination of homogeneous and heterogeneous catalysis.

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“…Synthesis of the Fréchet dendrons with N,Osalicylaldimine ligands (1)(2)(3) or Fréchet organometallic dendrons with Rh(I) N,O-salicylaldimine complexes at the focal point (4-9).…”

Section: Methodsmentioning

confidence: 99%

Section: Synthesis and Characterisation Of Fréchet Dendrons With Nosa...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synthesis and hydroformylation evaluation of Fréchet-type organometallic dendrons with N,O-salicylaldimine Rh(i) complexes at the focal point

et al. 2018

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“…First synthesized by Vogtle and co-workers in 1978, dendrimers are branched, spherical macromolecules widely used to encapsulate objects ranging from NPs to drugs. − Poly(amidoamine) (PAMAM) dendrimers are a dendrimer subclass that consists of an alkyl-diamine core, amidoamine branches, and a vast range of peripheral functionalities (Scheme ). The size of PAMAM dendrimers depends on the number of reaction cycles carried out during the synthesis .…”

Section: Introductionmentioning

confidence: 99%

Electrocatalytic Reduction of Oxygen on Platinum Nanoparticles in the Presence and Absence of Interactions with the Electrode Surface

Ostojic

Crooks

2016

Langmuir

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We report that ultraviolet/ozone (UV/O3) treatment can be used to remove sixth-generation, hydroxyl-terminated poly(amidoamine) (PAMAM) dendrimers from dendrimer-encapsulated Pt nanoparticles (Pt DENs) previously immobilized onto a pyrolyzed photoresist film (PPF) electrode. Results from X-ray photoelectron spectroscopy, scanning transmission electron microscopy, and electrochemical experiments indicate that removal of the dendrimer proceeds without changes to the size, shape, or electrocatalytic properties of the encapsulated nanoparticles. The UV/O3 treatment did not damage the PPF electrode. The electrocatalytic properties of the DENs before and after removal of the dendrimer were nearly identical.

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“…Dendritic molecules can be visualised as repetitive layers of multifunctional blocks of a protected and unprotected scheme of complimentary monomers typically resulting in a fractallike tree in which each incorporated layer serves as a platform for the successive layer (Tomalia and Cheng 2012). The first completely characterised repetitively branched and polyfuctional molecule was generated by Vogtle et al in 1978 from a protocol based on cycles of nucleophile amine addition to electron-poor cyanoalkene, followed by reduction of the cyano groups which in turn yields new amine moieties for further reactions (Buhleier et al 1978). Several other contributions like Vogtle's, particularly those form the research groups of Newkome, Denkwalter and Tomalia (Denkewalter et al 1982, Newkome et al 1985, Tomalia et al 1985 build upon experiments setting out some fundamental principles of molecular organisation pioneered by Flory in the middle of the 20th century (Flory 1942).…”

Section: Modulating Drug Releasementioning

confidence: 99%

Application of nanotechnology for the development of microbicides

et al. 2016

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The vaginal route is increasingly being considered for both local and systemic delivery of drugs, especially those unsuitable for oral administration. One of the opportunities offered by this route but yet to be fully utilised is the administration of microbicides. Microbicides have an unprecedented potential for mitigating the global burden from HIV infection as heterosexual contact accounts for most of the new infections occurring in sub-Saharan Africa, the region with the highest prevalent rates. Decades of efforts and massive investment of resources into developing an ideal microbicide have resulted in disappointing outcomes, as attested by several clinical trials assessing the suitability of those formulated so far. The highly complex and multi-level biochemical interactions that must occur among the virus, host cells and the drug for transmission to be halted means that a less sophisticated approach to formulating a microbicide e.g. conventional gels, etc may have to give way for a different formulation approach. Nanotechnology has been identified to offer prospects for fabricating structures with high capability of disrupting HIV transmission. In this review, predominant challenges seen in microbicide development have been highlighted and possible ways of surmounting them suggested. Furthermore, formulations utilising some of these highly promising nanostructures such as liposomes, nanofibres and nanoparticles have been discussed. A perspective on how a tripartite collaboration among governments and their agencies, the pharmaceutical industry and academic scientists to facilitate the development of an ideal microbicide in a timely manner has also been briefly deliberated.

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ChemInform Abstract: ′CASCADE′‐ AND ′NONSKID‐CHAIN‐LIKE′ SYNTHESES OF MOLECULAR CAVITY TOPOLOGIES

Abstract: Ausgehend von Monoaminen (I) und Diaminen (V) werden in einer Kaskaden‐Reaktion durch Cyanethylierung und Reduktion zu Aminen polyfunktionelle Derivate (IV) bzw. (VI) erhalten.

Cited by 52 publications

References 1 publication

Synthesis and hydroformylation evaluation of Fréchet-type organometallic dendrons with N,O-salicylaldimine Rh(i) complexes at the focal point

Synthesis and hydroformylation evaluation of Fréchet-type organometallic dendrons with N,O-salicylaldimine Rh(i) complexes at the focal point

Electrocatalytic Reduction of Oxygen on Platinum Nanoparticles in the Presence and Absence of Interactions with the Electrode Surface

Application of nanotechnology for the development of microbicides

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