ChemInform Abstract: ALKYL ESTERS OF ALKOXY(DIHALO‐ AND ALKOXYHALOPHOSPHONYL)ACETIC ACIDS AND THEIR DERIVATIVES

Abstract

Dihalogenphosphite (I) und (V) setzen sich in Gegenwart von Eisen‐ (III)‐chlorid mit Alkylestern der Alkoxy‐chloressigsäure (II) zu Alkylestern der Alkoxy‐(dihalogenphosphonyl)‐essigsäuren (IIIa) und (IIIb) bzw. (VIa) und (VIb) um.

Phosphonate–phosphonochloridate conversion

“…[11,16,22,36,38,42] The chlorination has been also described in the absence of solvent. [5][6][7][8]13,20,21,80,81,[88][89][90] In that case the reagents are mixed then heated for about 4 h at temperatures between 60 and 90°C, but yields are a little lower and less predictable. No important variations have been made with the ester groups which are invariably methyl or ethyl groups, scarcely higher homologues, and sometimes benzyl groups.…”

“…[82] The R groups bound to phosphorus are represented by alkyl, [9,[13][14][15]18,34,[38][39][40]42,84,85,88] aryl, [32] benzyl, [16,26,28,36,43] norbornyl, [87] halogenoalkyl, [8,12,22,24,31,41,83],vinyl, [11,37,42] phtalimido-methyl [23,30] andethyl, [27,33,35] phosphonoethyl, [19] formic, [17,21,80,86] acetic, [5,20,21,29] propionic [21] and butanoic [29] esters, ethyl- [25] and benzylisocyanate, [7] enamides [90]...…”