Chemiluminescence-Guided Cancer Therapy Using a Chemiexcited Photosensitizer

Abstract

Organic nanoparticles exhibiting intense FR/NIR chemiluminescence and strong chemiexcited singlet oxygen generation in the presence of H 2 O 2 have been successfully used for selective tumor imaging and therapy. Both tumor chemiluminescent signals and singlet oxygen production can be further enhanced in the presence of an anti-tumor drug, FEITC, which could increase the amount of H 2 O 2 at the tumor site for effective tumor treatment. Our design represents a new strategy for light-source-free image-guided tumor therapy.

All Eyes on Visible‐Light Peroxyoxalate Chemiluminescence Read‐Out Systems

“…[66,68] In the recent past, severalg roups have demonstrated the use of photosensitisers for imageguided therapy.P hotosensitisers act as FR/NIR emitters, which simultaneously generate singlet oxygen speciesu pon chemical excitation.T his effect was observed to efficiently induce tumour cell apoptosis and cell growth inhibition. [63,64,68,69] Mao et al demonstrated aw ay to further enhance the chemiluminescencei ntensity by treating mice with the anti-cancer drug b-phenylethyl isothiocyanate boosting the H 2 O 2 production in tumour tissues and therefore the treatment efficiency (Scheme 3). [68] Moreover,C ho et al reported simultaneous tissue imaging and therapy through employment of ahydroxybenzyla lcohol oxalate copolymer encapsulated in micelles.…”

“…[63,64,68,69] Mao et al demonstrated aw ay to further enhance the chemiluminescencei ntensity by treating mice with the anti-cancer drug b-phenylethyl isothiocyanate boosting the H 2 O 2 production in tumour tissues and therefore the treatment efficiency (Scheme 3). [68] Moreover,C ho et al reported simultaneous tissue imaging and therapy through employment of ahydroxybenzyla lcohol oxalate copolymer encapsulated in micelles. By scavenging H 2 O 2 from inflamed sites, they were able to yield IR images of the tissue.…”

“…Scheme3.a) The preparation of C-TBD nanoparticles. b) Illustrationo fthe principle for chemiluminescence and 1 O 2 generation of C-TBD nanoparticles in the presence of H 2 O 2 .R eproduced from Ref [68]. with kind permission from Elsevier, Copyright 2017.…”

Biomacromolecule‐Functionalized AIEgens for Advanced Biomedical Studies

“…FR/NIR long‐wavelength emission AIEgen shows high penetration depth and low biological autofluorescence interference, holding great promise for tumor diagnostics. In order to achieve eradication of tumors, Liu and co‐workers reported an AIE nanomaterial for diagnosis and killing tumors in the presence of H 2 O 2 , endowing far‐red/near‐infrared self‐emission and 1 O 2 generation ( Figure ). This nanomaterial (C‐TBD NPs) have two important components (CPPO and a suitable AIE active photosensitizer TBD), coencapsulated to increase waters solubility and biocompatibility by pluronic F‐127.…”

“…The composite structures of the hydrophobic F127 and soybean oil encapsulated the functionalized TBD self‐assembly into C‐TBD NPs; its principle for chemiluminescence and 1 O 2 generation under the H 2 O 2 in the internal environment and the precise and specific imaging and treatment of C‐TBD NPs in abdominal tumor. Adapted with permission . Copyright 2017, Elsevier Inc.…”