Chemical structural and chain conformational characterization of some bioactive polysaccharides isolated from natural sources

Yang, Liqun; Zhang, Liming

doi:10.1016/j.carbpol.2008.12.015

Cited by 587 publications

(221 citation statements)

References 184 publications

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“…The fractions obtained (220-260 min) were combined, concentrated, dialyzed against flowing tap-water and lyophilized to obtain the major fraction BP1 (1.25 g). Generally speaking, the bioactivities of polysaccharides are closely dependent on their structures, including monosaccharide composition and sequence, glucosidic bonds, configuration and chain conformation [30][31][32]. However, it has not been clear if the pattern-recognition receptors of the cell membrane might be specific to the α,β-configuration of polysaccharides.…”

Section: Isolation and Purification Of Bp1mentioning

confidence: 99%

Chemical Structure and Immunomodulating Activities of an α-Glucan Purified from Lobelia chinensis Lour

Bao

Leung

et al. 2016

Molecules

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A neutral α-glucan, named BP1, with a molecular mass of approximately 9.45 kDa, was isolated from Lobelia chinensis by hot-water extraction, a Q-Sepharose Fast Flow column and Superdex-75 column chromatography. Its chemical structure was characterized by monosaccharide analysis, methylation analysis and analysis of its FT-IR, high performance gel permeation chromatography (HPGPC) and 1D/2D-NMR spectra data. The backbone of BP1 consists of The results of the effect of BP1 on mouse macrophage cell line RAW 264.7 indicate that BP1 enhances the cell proliferation, phagocytosis, nitric oxide production and cytokine secretion in a dose-dependent manner. Because the inhibitor of Toll-like receptor 4 blocks the BP1-induced secretion of TNF-α and IL-6, we hypothesize that α-glucan BP1 activates TLR4, which mediates the above-mentioned immunomodulating effects.

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Section: Isolation and Purification Of Bp1mentioning

confidence: 99%

Chemical Structure and Immunomodulating Activities of an α-Glucan Purified from Lobelia chinensis Lour

Bao

Leung

et al. 2016

Molecules

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“…Although a thorough elucidation of the structure and chain conformation of a polymer may be tasking, a wide range of techniques are available to extensively characterize and uniquely identify a polymer. Structure characterizations are undertaken with Fourier Transform Infrared spectroscopy (FTIR), liquid-state Nuclear Magnetic Resonance (NMR) (One and two dimensions), solid-state NMR, Raman spectroscopy, gas chromatography (GC), GC-Mass spectroscopy (MS), and high performance liquid chromatography [50]. The chain conformations of polysaccharides in solutions are elucidated with static and dynamic light scattering, viscosity analysis, circular dichroism analysis, single molecular atomic force microscopy (AFM), AFM-based single-molecule force spectroscopy, florescence correlation spectroscopy and NMR spectroscopy [50].…”

Section: Structural Elucidation Of Natural Polymersmentioning

confidence: 99%

Naturapolyceutics: The Science of Utilizing Natural Polymers for Drug Delivery

2014

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Naturapolyceutics defines the emerging science and technology platform that blends natural polymers and pharmaceutics for the design and development of drug delivery systems. Natural polymers due to their biological properties, sustainability, chemical flexibility, human and eco-friendliness are promising in this field. As drug delivery advances, there will be need for more polymers. Given that polymers utilized in pharmaceuticals require regulatory approval, robust processes are undertaken to facilitate the production of pharmaceutical grade natural polymers. This review provides insight into the processes-extraction, purification, modifications and characterizations-involved in the eventual utilization of natural polymers for drug delivery. The versatility of natural polymers and particularly modified natural polymers in targeted drug delivery, micro-/nano-drug delivery, theranostics, BioMEMs and generally in research and development of highly efficient, safe and quality products is demonstrated. Natural polymers are polymers of today and tomorrow. Therefore, the shift to undertake training, extensive research and subsequent commercialization of more natural polymers-novel and underutilized-for drug delivery is now!

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“…It is known that, like proteins, polysaccharides are capable of interacting with an organism causing a change in biological activity (Yang and Zhang, 2009). The interaction and effect of the interaction varies greatly due to the conformation (Yang and Zhang, 2009) and other potential interactions of the polysaccharide (Patel, et al, 2007;Heinze, et.…”

Section: Introductionmentioning

confidence: 99%

“…The interaction and effect of the interaction varies greatly due to the conformation (Yang and Zhang, 2009) and other potential interactions of the polysaccharide (Patel, et al, 2007;Heinze, et. al., 2011).…”

Section: Introductionmentioning

confidence: 99%

The anti-diabetic potential of polysaccharides extracted from members of the cucurbit family: A review

Simpson

Morris

2014

Bioactive Carbohydrates and Dietary Fibre

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Diabetes is a growing global problem and a heavy financial burden on health care services. It is estimated that over 380 million people suffer from this condition which causes many deaths each year in addition to being associated with increased risk of other health problems.Traditional medicine is a promising area of research in diabetes therapy as it is widely accessible and it is believed that over 200 plants have anti-diabetic properties including members of the cucurbit family. Studies in animal and human models have shown that treatment with some cucurbits has hypoglycaemic effects and stimulates beta cell regeneration in addition to other anti-diabetic effects which are equal to that of commonly prescribed anti-diabetic drugs. It has also been shown that at least one of the bioactive components which stimulate these effects is a polysaccharide.

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Chemical structural and chain conformational characterization of some bioactive polysaccharides isolated from natural sources

Cited by 587 publications

References 184 publications

Chemical Structure and Immunomodulating Activities of an α-Glucan Purified from Lobelia chinensis Lour

Chemical Structure and Immunomodulating Activities of an α-Glucan Purified from Lobelia chinensis Lour

Naturapolyceutics: The Science of Utilizing Natural Polymers for Drug Delivery

The anti-diabetic potential of polysaccharides extracted from members of the cucurbit family: A review

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