Chemical Senses Affecting Cough and Swallowing

Ebihara, Satoru; Izukura, Hideaki; Miyagi, Midori; Okuni, Ikuko; Sekiya, Hideki; Ebihara, Takae

doi:10.2174/1381612822666160216151342

Cited by 6 publications

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“…This highlights the importance of preventing AP, potentially by using sensory stimulation. 28 In the present study, comorbid atrial fibrillation was a crucial prognostic factor of 90-day mortality. To the best of our knowledge, ours is the first study to show this association in patients with HCAP.…”

Section: Discussionmentioning

confidence: 49%

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Prognostic factors of 90‐day mortality in older people with healthcare‐associated pneumonia

Ebihara

Miyamoto

Kozaki

2020

Geriatrics Gerontology Int

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Aim: The Quick Sequential Organ Failure Assessment, and confusion, urea, respiratory rate, blood pressure and age (CURB-65) scores have been used as prognostic factors of mortality related to healthcare-associated pneumonia. However, aspiration pneumonia remains unclear. Methods: A cross-sectional, prospective cohort study was carried out with 130 inpatients aged ≥75 years at a Geriatric ward of Kyorin University Hospital, Japan. We investigated the utility of aspiration pneumonia-related factors, latency of swallowing reflex and cough reflex sensitivity, serum albumin levels, the neutrophil-to-lymphocyte ratio, and conventional scores of pneumonia severity, for predicting 30-and 90-day healthcare-associated pneumonia mortality. Patient demographics, cognition, physical activity (Barthel Index), eating ability (Food Intake Level Scale), dementia stage (Functional Assessment Staging Tool), performance status (Zubrod score), current medications and comorbidities were collected. Pneumonia severity was evaluated using the Quick Sequential Organ Failure Assessment, CURB-65 and Systemic Inflammatory Response Syndrome criteria scores. Results: Age, Barthel Index, Zubrod, Functional Assessment Staging Tool and Food Intake Level Scale scores were significantly associated with mortality, whereas the conventional scores were not. The Kaplan-Meier method with the log-rank test using Cox proportional hazards analysis showed that serum albumin levels <2.75 and the comorbidity of atrial fibrillation were associated with a lower survival rate in deceased versus surviving individuals at 90 days. In addition, a deteriorated latency of swallowing reflex and a blunted cough reflex sensitivity were associated with 90-day mortality. Conclusions: Hypoalbuminemia, atrial fibrillation, deteriorated latency of swallowing reflex and blunted cough reflex sensitivity values were better predictors of 90-day mortality than traditional scores in older individuals with healthcare-associated pneumonia.

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Section: Discussionmentioning

confidence: 49%

“…Thus, malnutrition and a compromised immune status are more important prognostic factors of 90‐day mortality than feeding ability. This highlights the importance of preventing AP, potentially by using sensory stimulation 28 …”

Section: Discussionmentioning

confidence: 89%

Prognostic factors of 90‐day mortality in older people with healthcare‐associated pneumonia

Ebihara

Miyamoto

Kozaki

2020

Geriatrics Gerontology Int

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“…Chemical type receptors, located mainly in the respiratory tract, are activated by acids, heat and capsaicin-like molecules that act on capsaicin type-1 receptors. The mechanical type receptors are located not only in the respiratory tract but also in the in the paranasal sinuses, eardrum, external auditory canal, in pleura, pericardium, diaphragm, and stomach [2]. The different types of sensory receptors are connected to the CNS through afferent fibers that travel in the Vagus nerve (cranial nerve X) to the respiratory centers located in the brainstem.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of a Medical Device Based on Plant Extracts for the Symptomatic Treatment of Cough in Children and Adults. A Clinical Study

Pecora¹

2021

SJO

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Cough is one of the most common medical situations that leads to seek medical attention. The present study was carried out to evaluate the efficacy and tolerability in the treatment of cough in adults and children of a sugar-free syrup containing glycerol and extracts from roots of Althaea officinalis and from leaves of Plantago lanceolata (FTP 65 Cough syrup sugar free: Manufacturer Labomar SPA). One hundred and twenty subjects (60 children and 60 adults) were recruited. Participants received for 7 days one of the following dosage schedules: a) Adult: " Cough Syrup REF FTP 65" in single-dose containers of 10 ml, to be taken daily in 3 administrations b) Children: " Cough Syrup REF FTP 65" with a daily dosage of 10 ml/day for 2-6-year-old children, and of 20 ml/day, for 7-12-year-old children. The survey included three visits: a first visit (V0) of enrollment, a second visit (V1) after 3 days from the V0 and a third visit (V2) carried out after 7 days of therapy. The results of this study confirm the evidence that the medical device Cough Syrup REF FTP 65 may represent a valid choice as a treatment for coughing in adults and children

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Examining the Influence of Chemosensation on Laryngeal Health and Disorders

et al. 2023

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Chemical Senses Affecting Cough and Swallowing

Abstract: Whenever you prescribe for an abnormality of one of the reflexes, you should think about the effect of the prescription on the other reflex.

Cited by 6 publications

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Prognostic factors of 90‐day mortality in older people with healthcare‐associated pneumonia

Prognostic factors of 90‐day mortality in older people with healthcare‐associated pneumonia

Efficacy of a Medical Device Based on Plant Extracts for the Symptomatic Treatment of Cough in Children and Adults. A Clinical Study

Examining the Influence of Chemosensation on Laryngeal Health and Disorders

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