“…The presence of TAN at a concentration as low as 1 mM has a marked effect ; this curve is comparable to approximately 5 mM Miso alone . Lack of sensitization by nitroxyls in tissues or pellet may be due to reduction of the free radical, enzymatic degradation, or some inactivation due to binding (Millar, Fielden and Smithen 1977, Blackett, Wooliscroft, Fielden and Skov et al Lillicrap 1974, Agnew andSkarsgard 1974) . Figure 6 shows that 50 mM TAN, with or without Miso, is very toxic .…”