The Role of Cellular Glutathione in Response of Tumor Cells to Radiation and Drugs

Biaglow, John E.; Varnes, Marie E.; Clark, Edward P.; Epp, Edward R.

doi:10.1007/978-1-4613-2331-0_11

Biochemical Modulation of Anticancer Agents: Experimental and Clinical Approaches 1986

DOI: 10.1007/978-1-4613-2331-0_11

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The Role of Cellular Glutathione in Response of Tumor Cells to Radiation and Drugs

John E. Biaglow¹,

Marie E. Varnes²,

Edward P. Clark³

et al.

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1986

1992

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Cited by 3 publications

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Selenite-induced inhibition of colony formation by buthionine sulfoximine-sensitive and resistant cell lines

Caffrey

Frenkel

1992

Biol Trace Elem Res

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We previously demonstrated that treatment of HeLa cells with buthionine sulfoximine (BSO), which decreases the level of cellular glutathione, resulted in a decrease in the potency of selenite in inhibiting cell colony formation. We have now examined the effect of selenite on normal human lung fibroblast (CCL-210) cells, which resemble HeLa cells in their sensitivity to BSO, and on human lung adenocarcinoma (A549) cells, which are relatively insensitive to BSO. We have found that BSO treatment caused an approximately fourfold decrease in selenite potency in the CCL-210 cells, but had no significant effect on its potency in A549 cells. These results support the hypothesis that for selenite to exert its cytotoxic effect, it must undergo the reaction with an SH compound to form the selenotrisulfide. As a result of the lower sensitivity of the tumor cells to BSO, it was possible to achieve a large differential sensitivity to the cytotoxic effect of selenite.

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Selenite-induced inhibition of colony formation by buthionine sulfoximine-sensitive and resistant cell lines

Caffrey

Frenkel

1992

Biol Trace Elem Res

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The effect of L-buthionine sulfoximine on the aerobic radiation response of A549 human lung carcinoma cells

Biaglow

Varnes

Tuttle

et al. 1986

International Journal of Radiation Oncology*Biology*Physics

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Role of Glutathione and Other Thiols in Cellular Response to Radiation and Drugs

Biaglow

Varnes

Epp

et al. 1989

Drug Metabolism Reviews

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The Role of Cellular Glutathione in Response of Tumor Cells to Radiation and Drugs

Cited by 3 publications

References 43 publications

Selenite-induced inhibition of colony formation by buthionine sulfoximine-sensitive and resistant cell lines

Selenite-induced inhibition of colony formation by buthionine sulfoximine-sensitive and resistant cell lines

The effect of L-buthionine sulfoximine on the aerobic radiation response of A549 human lung carcinoma cells

Role of Glutathione and Other Thiols in Cellular Response to Radiation and Drugs

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