Chemical Mediation of Interactions Among Marine Organisms

Paul, Valerie J.; Puglisi, Melany P.

doi:10.1002/chin.200420242

Cited by 16 publications

(21 citation statements)

References 129 publications

(165 reference statements)

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“…This implies that the anticandidal bioactive metabolite in the algae might be readily soluble in PBS rather sparingly soluble in the organic solvents. Earlier reports on the effectiveness of extraction methods evidenced that methanol extraction yielded higher antimicrobial activity than n-hexane and ethyl acetate (Rosell and Srivatsava, 1987;Sastry and Rao, 1994;Paul and Puglisi, 2004). Whereas others reported that chloroform is a better solvent than methanol and benzene (Fables et al, 1995).…”

Section: Activity Of Seaweeds Extractsmentioning

confidence: 98%

“…The results of the present study showed that methanol:toulene extract of Padina was effective against E. coli, P. mirabilis, M. luteus and E. faecalis. Previous studies have demonstrated that brown algae produce a wide variety of isoprenoid metabolites as defences against herbivory a well as to prevent antifouling (Paul and Puglisi, 2004). From the evolutionary perspective, it would be important to determine if the same molecules that daunt herbivory and/or prevent biofouling also function as antimicrobial chemical defences.…”

Section: Antibacterial Activity Of the Tested Seaweedsmentioning

confidence: 99%

“…Harder (1917) was the pioneer to observe the antimicrobial potentials of seaweeds. Many algal species have been shown to have bactericidal or bacteriostatic substances (Glombitza, 1979;Michanek, 1979;Fenical and Paul, 1984;Paul and Puglisi, 2004). The bactericidal agents found in algae include aminoacids, terpenoids, phlorotannins, acrylic acid, phenolic compounds, steroids, halogenated ketones and alkanes, cyclic polysulphides and fatty acids (Watson and Cruz-Rivera, 2003).…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial activity of seaweeds extracts against multiresistant pathogens

et al. 2008

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Fourteen seaweeds collected from the intertidal zone of Southwest coast of India were tested against ten human pathogen bacteria and one human pathogen fungus using the well diffusion test in the casitone agar medium. The species used in the present study include five Chlorophyta (Bryopsis plumosa, Ulva fasciata, Acrosiphonia orientalis, Chaetomorpha antennina, Grateloupia filicina), five Rhodophyta (Hypnea pannosa, Gracilaria corticata, Centroceras clavulatum, Portieria hornemannii, Cheilosporum spectabile) and four Phaeophyta (Padina tetrastromatica, Sargassum wightii, Stocheospermum marginatum, Chnoospora bicanaliculata). Of these, seven species were determined to be highly bioactive and screened on the multiresistant pathogens. We found that drying process has eliminated the active principles in the seaweeds. In the present study, methanol:toluene (3:1) was found to be the best solvent for extracting the antimicrobial principles from fresh algae. However, the ethanolic extract showed no antibacterial activity. Acrosiphonia orientalis showed activity against 70% of the tested organisms. Stocheospermum marginatum was the only seaweed that showed activity against Klebsiella pneumoniae. The extract from Gracilaria corticata was highly active against Proteus mirabilis, a Gram negative pathogenic bacterium. The present findings revealed that the tested seaweeds were highly active against Gram negative bacteria than Gram positive bacteria. The antimicrobial principle from seaweed was found to be a lipophilic compound. The compound was stable over a wide range of temperature (30-60 °C). The active principles of highly active seaweeds Acrosiphonia orientalis and Stocheospermum marginatum were bactericidal.

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Section: Activity Of Seaweeds Extractsmentioning

confidence: 98%

Section: Antibacterial Activity Of the Tested Seaweedsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antimicrobial activity of seaweeds extracts against multiresistant pathogens

et al. 2008

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“…An immense number of organisms in the marine environment, including the marine algae, produce a variety of chemical deterrents for defence purposes, which have served as the basis for ecological studies (Paul and Puglisi 2004;Kubanek et al 2003;Steinberg and de Nys 2002;Engel et al 2002;Ren et al 2001;Nagle and Paul 1999;Hay 1996;Hay and Steinberg 1992;Bakus et al 1986). There have been numerous studies, across the globe, reporting the bioactivities of marine-sourced organisms (e.g.…”

Section: Introductionmentioning

confidence: 99%

Exploitation of marine algae: biogenic compounds for potential antifouling applications

Bhadury

Wright

2004

Planta

281

173

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Marine algae are one of the largest producers of biomass in the marine environment. They produce a wide variety of chemically active metabolites in their surroundings, potentially as an aid to protect themselves against other settling organisms. These active metabolites, also known as biogenic compounds, produced by several species of marine macro- and micro-algae, have antibacterial, antialgal, antimacrofouling and antifungal properties, which are effective in the prevention of biofouling, and have other likely uses, e.g. in therapeutics. The isolated substances with potent antifouling activity belong to groups of fatty acids, lipopeptides, amides, alkaloids, terpenoids, lactones, pyrroles and steroids. These biogenic compounds have the potential to be produced commercially using metabolic engineering techniques. Therefore, isolation of biogenic compounds and determination of their structure could provide leads for future development of, for example, environmentally friendly antifouling paints. This paper mainly discusses the successes of such research, and the future applications in the context of understanding the systems biology of micro-algae and cyanobacteria.

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Section: Introductionmentioning

confidence: 99%

Antimicrobial potential of a marine seaweedAsparagopsis taxiformis againstLeptospira javanica isolates of rodent reservoirs

et al. 2009

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In this present investigation pharmacologically active compounds were isolated from red algae (Asparagopsis taxiformis) and their efficacy was evaluated against the Leptospira javanica isolates of rodent carriers. The GC-MS analysis of the purified compound revealed the presence of 4,5-dimethyl-1H-pyrrole-2-carboxylic acid ethyl ester (56.012%), fattyacids, 14-methyl-pentadecanoic acid methyl ester (26.6%), octadecanoic acid methyl ester (8.46%), octadec-9-enoic acid 2,3-dihydroxy-propyl ester (4.11%), 9-octadecanoic acid, methyl ester (4.535%) and trace amount of chlorobenzene (0.09%). MICs and MBCs of the purified compound against pathogenic leptospiral strains belonging to 14 serovars and 11 isolates belonging to serovar javanica of Leptospira borgpetersenii were determined in a range of 100-1600 μg/ml. The antibiotics penicillin and doxycycline were used as the standards for the efficiency determination of the seaweed extract against the leptospiral reference serovars and isolates. The minimal inhibitory concentration of penicillin and doxycyline were in the range of 25-200 μg/ml. The seaweed active fraction exhibited comparable MIC and MBC values with that of the standard antibiotic doxycycline. In the present study the seaweed compound has been developed to apply for the 2 nd nodal point of transmission cycle, the environment. Thus the present study draws the development of a novel drug to treat leptospires particularly in environments augmented with rodent carriers.

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Chemical Mediation of Interactions Among Marine Organisms

Abstract: This review covers the recent marine chemical ecology literature for macroalgae, sponges, octocorals and other benthic invertebrates; 332 references are cited.

Cited by 16 publications

References 129 publications

Antimicrobial activity of seaweeds extracts against multiresistant pathogens

Antimicrobial activity of seaweeds extracts against multiresistant pathogens

Exploitation of marine algae: biogenic compounds for potential antifouling applications

Antimicrobial potential of a marine seaweedAsparagopsis taxiformis againstLeptospira javanica isolates of rodent reservoirs

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