Chemical Examination of Embelia ribes. I. Isolation of a New Constituent, “Vilangin,” Its Constitution and Synthesis

Rao, C. Radhakrishna; Venkateswarlu, V.

doi:10.1021/jo01069a079

Cited by 26 publications

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“…There are various chemical constituents present in the E. ribes plant. The vilangin compound was extracted from the dry ripe berries of E. ribes plant [19]. The other constituents isolated are volatile oils, fixed oil, resin, tannin, christembine (alkaloid), phenolic acids such as caffeic acid, vanillic acid, chlorogenic acid, cinnamic acid, o-cumaric acid from the berries of E. ribes plant [20].…”

Section: Phytochemical Constituents Of Embelia Ribesmentioning

confidence: 99%

Vaibidang (Embelia ribes): A Potential Herbal Drug in Ayurveda with Anthelmintic Property

Choudhary¹,

Kaurav²,

Chaudhary³

2021

Int. j. res. appl. sci. biotechnol.

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Embelia ribes is commonly known as vaibidang or false black pepper is a significant medicinal plant that belongs to the family Myrsinaceae. The ancient Ayurveda physician, Sushruta described that the fruit of E. ribes plant possesses anthelmintic property and is used as a tonic along with the licorice root, which prevents aging and helps in strengthening the body. The fruit of the plant is used in various ayurvedic formulations where it is used as a carminative, anthelmintic, alterative and as stimulant. Due to the overexploitation of the plant, it is considered a threatened medicinal plant. Traditionally, the plant is used as an analgesic, antibacterial, antipyretic, antifertility and anthelmintic agent. Various parts of the plant like roots, berries and leaves of E. ribes plant are used in different herbal formulations. In Ayurveda, it is used to cure skin diseases, abdominal pains, flatulence, worms, mental disorders, tumors, bronchitis, jaundice, cardio disorders and is used as a brain tonic. Embelin is considered as the major chemical constituent isolated from the Embelia ribes plant. In this review, a brief view of the plant is briefly described related to its ayurvedic and folk uses. The reported pharmacological properties of the plant are also defined.

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Section: Phytochemical Constituents Of Embelia Ribesmentioning

confidence: 99%

Vaibidang (Embelia ribes): A Potential Herbal Drug in Ayurveda with Anthelmintic Property

Choudhary¹,

Kaurav²,

Chaudhary³

2021

Int. j. res. appl. sci. biotechnol.

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“…Vilangin was isolated from the dry ripe berries of E. ribes. The structure was assigned as methylenebis (2, 5-dihydroxy-4-undecyl-3-6-benzoquinone) [14] . 3 new compounds identified as embelinol, embeliaribyl ester and embeliol were isolated from the seeds of Embelia ribes along with embelin [15] .…”

Section: Phytochemistrymentioning

confidence: 99%

Endangered Medicinal Plant Embelia ribes Burm.f.- A Review

Harish¹,

Danapur²,

Jain³

et al. 2012

Pharmacognosy Journal

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potential as a therapeutic agent for osteoporosis and cancerlinked bone loss [7,8]. Recent findings also suggest embelin as a novel adjuvant therapeutic candidate for the treatment of hormone-refractory prostate cancer that is resistant to radiation therapy. [9] Morphology Embelia ribes Burm. f., is a large scandent shrub; branches long, slender, flexible, terete with long internodes, the bark studded with lenticels. Leaves coriaceous, 5-9 by 2-3.8 cm., elliptic or elliptic lanceolate, shortly and obtusely acuminate, entire, glabrous on both sides, shining above, paler and somewhat silvery beneath, the whole surface covered with scattered minute reddish sunken gland (conspicuous in the young leaves), base rounded or acute; main nerves numerous, slender; petioles 6-16 mm. long, more or less margined, glabrous. Flowers penta-merous, numerous, small, in lax panicled racemes which are terminal and from the upper axils; branches of the panicle often 7.5-10 cm long with more or less glandular pubescent; bracts minute, setaceous, deciduous. Calyx is about 1.25 mm. long; sepals connate about 1/3 rd of the way up, the teeth 5, broadly triangular-ovate, ciliate. Petals 5, greenish yellow, free, 4 mm. long, elliptic, subobtuse, and pubescent on both sides. Stamens 5, shorter than the petals, erect; filaments inserted a little below the middle of the petals. Fruit is globose, 3-4 mm. diam., smooth, succulent, black when ripe, like a peppercorn when dried, tipped with the persistent style [10]. Fig 1.

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“…Embelin (3-undecyl 2, 5-dihydroxy ,1,4 -benzoquinone) was an important naturally occurring alkyl substituted hydroxyl benzoquinone product and one of the main constituent of embelia ribes burm ,fruits of the plants contain a quinine derivative embelinan alkaloid chiristembine 4 and volatile oil vilangin ,its chemical constituent is 2,5-dihydroxy -4-undecyl-3,6 -benzoquinone 5 . The variety of biological activities of this compounds have been studied and evaluated for anti spermatogenic effect 6 and urinary tract infection 7 .Literature review shows that the phytochemical and pharmacological properties of embeliaribes as a medicinal plant had studied.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterisations, Lipid Lowering Activity and Antibacterial Activities of Some Benzoyl Ester Substituted Embelin Derivatives

Patange¹

2017

Orient. J. Chem

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The research article represents the extraction of Embelin from its plant source and synthesis, characterisation, lipid lowering activities and antibacterial studies of some Benzoyl ester substituted derivatives of Embelin. The derivatives of Embelin, EL -1 to EL -5 were prepared by treating Embelin with Meta and Para substituted benzoyl chloride in presence of base pyridine and dichloromethane. Benzoyl ester substituted derivatives of Embelin molecule also shows more or less medicinal properties then the parent Embelin molecule. The synthesized compound were characterised and identified on the basis of elemental analysis, UV, FTIR, Mass and NMR spectroscopy and their antibacterial activities were studied against test organism viz B. subtilis gram positive, S.aureus Gram positive, C.Albicans Antifungal and E.coli Gram negative. The lipid lowering activities of prepared compound were also studied in percentage on pancreatic lipase inhibition simply on the basis of change in international unit (IU).

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Chemical Examination of Embelia ribes. I. Isolation of a New Constituent, “Vilangin,” Its Constitution and Synthesis

Cited by 26 publications

References 0 publications

Vaibidang (Embelia ribes): A Potential Herbal Drug in Ayurveda with Anthelmintic Property

Vaibidang (Embelia ribes): A Potential Herbal Drug in Ayurveda with Anthelmintic Property

Endangered Medicinal Plant Embelia ribes Burm.f.- A Review

Synthesis, Characterisations, Lipid Lowering Activity and Antibacterial Activities of Some Benzoyl Ester Substituted Embelin Derivatives

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