Chemical constituents from the flower of Datura metel L.

Kuang, Hai‐Xue; Yang, Bing‐You; Xia, Yueyuan; Wang, Feng

doi:10.1007/s12272-001-1274-6

Cited by 90 publications

(31 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…22 All species of the genus Datura are members of the Solanaceae family and the taxonomy of Datura genera is imprecise and poorly understood. [22][23][24][25][26] It is estimated that there are 15-25 different Datura species that are indigenous to many parts of the world including Europe, North America, North Africa, and eastern and southwestern Asia. 24,26 The more common species are listed in Table 2.…”

Section: History and Taxonomymentioning

confidence: 99%

“…6). [21][22][23][24][25][26][27][28] There are significant interspecies differences and the ratio of atropine to scopolamine and the presence of at least 26 other related alkaloids will vary even between and among specimens of the same species. 28 The differences may account for unexpected doseresponse effects that are observed in some patients and even different profiles of toxicity [e.g., more or less central nervous system (CNS) activity].…”

Section: Mechanisms Of Toxicitymentioning

confidence: 99%

See 1 more Smart Citation

Aspects ofDaturapoisoning and treatment

Krenzelok

2010

Clinical Toxicology

View full text Add to dashboard Cite

Introduction. Datura species, especially Datura stramonium (e.g., jimsonweed), are the focus of scores of case reports that chronicle the toxidrome of anticholinergic toxicity. Mechanisms of toxicity. Toxicity occurs because of the presence of up to 28 belladonna alkaloids, predominated by atropine and scopolamine. There are significant interspecies differences in the ratio of the belladonna alkaloids, atropine to scopolamine, and the presence of at least 26 other related alkaloids will vary, even between and among specimens of the same species. The differences may account for unexpected dose-response effects that are observed in some patients and even different profiles of toxicity. All parts of the Datura species contain belladonna alkaloids; in decreasing order, the belladonna alkaloid content is generally the greatest in the petioles (flowers), stem, fruit (seeds), leaves, and roots. Features. The most prominent symptoms are due to the blockade of peripheral muscarinic receptors that innervate exocrine glands, smooth muscle, and cardiac tissue. Therefore, the primary toxic manifestations include mydriasis, which is due to the blockade of papillary sphincter muscle and iris muscle; dry mouth, secondary to parasympathetic blockade of salivary secretion; tachycardia, caused by competition at muscarinic receptors in postganglionic parasympathetic neurons and blockade of receptors in the SA node; and fever and erythema, because of vasodilation and inhibition of sweating. Direct ocular exposure. Well known to produce mydriasis after ingestion, Datura is also notorious for producing maladies such as "gardeners eye" and "cornpickers eye," which is a testament to the high concentrations of belladonna alkaloids in the entire plant. When the sap or dried plant material from a member of the Datura species enters the eye directly, the papillary sphincter and ciliary muscles are affected resulting in mydriasis and cycloplegia. Pupil dilation is sudden in onset and often profound. In a dose-response fashion, the mydriasis and its persistence will be dependent on the alkaloidal content and quantity of the sap. The mydriasis can be bilateral, but most commonly it is unilateral, which is frightening to the victim and to the clinician and suggestive of significant cerebral pathology. Management. As with any toxic exposure, the foundation of patient management is supportive care and patient reassurance. Because of the central nervous system effects of the belladonna alkaloids, the patient may be agitated, combative, confused, and disoriented. Initial intervention focuses on addressing those issues that protect the patient and their caregivers. In severe cases, physostigmine, a cholinesterase inhibitor, should be used to reverse anticholinergic toxicity. Physostigmine should be given intravenously to an adult in a dose of 0.5-2.0 mg at a rate of no more than 1 mg/min; a second dose may be administered if necessary. Children should receive 0.02 mg/ kg intravenously and the rate should not exceed 0.5 mg/min. Extracorporeal eliminat...

show abstract

Section: History and Taxonomymentioning

confidence: 99%

Section: Mechanisms Of Toxicitymentioning

confidence: 99%

Aspects ofDaturapoisoning and treatment

Krenzelok

2010

Clinical Toxicology

View full text Add to dashboard Cite

show abstract

“…Four compounds were detected in methanolic extracts of flower, including cis-2-nitro-4-t-butylcyclohexanone (36.54%), acetic acid, trifluoro-, 2,2-dimethylpropyl ester (31.97%), 4-trifluoroacetoxyoctane (19.28%) and 1,4-cyclohexadiene, 1-methyl-(12.22%) [89]. Phytochemical investigation of the 50% ethanol fraction of macroporous resin of the flower of the plant led to the isolation of yangjinhualine A and five megastigmane sesquiterpenes [90]. Isofraxidin, scopatone, daturadiol ,1,4-benzenediol, arenarine D, vanillin, N-trans-feruloyl-tyramine, scopoletin , G-sitosterol and hyoscyamilactol were isolated from the seeds of Datura metel from Xinjiang Province [91].…”

mentioning

confidence: 99%

Medical importance of Datura fastuosa (syn: Datura metel) and Datura stramonium - A review

Al-Snafi¹

2017

IOSRPHR

View full text Add to dashboard Cite

Abstract:-The preliminary phytochemical investigation was performed on methanolic and hydroalcoholic extract of Datura fastuosa (syn: Datura metel) revealed the presence of alkaloids, tannins, cardiac glycosides, flavonoids, carbohydrates, amino acids and phenolic compounds, while, phytochemical analysis of Datura stramonium showed that it contained alkaloids, saponins, tannins, steroids, flavonoids, phenols and glycosides. The previous pharmacological studies of Datura fastuosa showed that it possessed antimicrobial insecticidal, antidiabetic, cytotoxic, antioxidant, antiinflammatory, analgesic, antipyretic, neurological, wound healing, reproductive and antispasmodic, while Datura stramonium exerted Antiepileptic, Anti-asthmatic, analgesic, antioxidant, antimicrobial, insecticidal, repellent and organophosphate protective effects. The current review highlights the chemical constituents and pharmacological effects of Datura fastuosa and Datura stramonium.

show abstract

“…The non-alkaloid water-soluble fraction of yangjinhua mediates the clinical effects on psoriasis and has antiinflammatory, anti-titillation of skin, and anti-anaphylaxis actions . We previously isolated flavonoids and withanolides from this fraction, including kaempferol, kaempferol-7-O-α-L-rhamnopyranoside, kaempferol-7-O-β-D-glucopyranoside, baimantuoluosines A-F, and baimantuoluosides A-C (Yang et al, 2006(Yang et al, , 2007Kuang et al, 2008Kuang et al, , 2009.…”

Section: Introductionmentioning

confidence: 99%

Baimantuoluosides D-G, four new withanolide glucosides from the flower of Datura metel L.

et al. 2010

Self Cite

View full text Add to dashboard Cite

In our search for bioactive anti-psoriasis compounds from the flower of Datura metel L, we isolated four new withanolide glucosides, baimantuoluosides D, E, F and G (1-4). The structures of the new compounds are (5alpha,6alpha,7beta,22R)-5,6,7,27-tetrahydroxy-1-oxowitha-2,24-dien-27-O-beta-D-glucopyranoside (1), (5alpha,6beta,7alpha,22R)-5,6,7,27-tetrahydroxy-1-oxowitha-2,24-dien-27-O-beta-D-glucopyranoside (2), (5alpha,6beta,7alpha,12beta,22R)-5,6,7,12,27-pentahydroxy-1-oxowitha-2,24-dien-27-O-beta-D-glucopyranoside (3), and (5alpha,6beta,22R)-5,6,27-trihydroxy-1-oxowitha-2,24-dien-27-O-beta-D-glucopyranoside (4) on the basis of chemical and physicochemical evidence.

show abstract

Chemical constituents from the flower of Datura metel L.

Cited by 90 publications

References 5 publications

Aspects ofDaturapoisoning and treatment

Aspects ofDaturapoisoning and treatment

Medical importance of Datura fastuosa (syn: Datura metel) and Datura stramonium - A review

Baimantuoluosides D-G, four new withanolide glucosides from the flower of Datura metel L.

Contact Info

Product

Resources

About