Chemical constituents from Lactuca inermis, a wild African species

Michalska, Klaudia; Kisiel, Wanda

doi:10.1016/j.bse.2014.02.027

Cited by 11 publications

(5 citation statements)

References 11 publications

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“…The calculated quantities (mg/dry weight) were slightly different from other literature data [17], but this is not uncommon for lettuce varieties of a particular provenience where soil properties, fertilization, irrigation, light, postharvest handling, and storage influence secondary metabolites quality and quantity. Our data showed similarity in regard to the fact that phenolic acid fractions were dominant in the lettuce leaves as compared to flavonoids.…”

Section: Resultscontrasting

confidence: 89%

“…Lactuca L. genus belongs to the family Asteraceae and comprises ~100 wild species [17]. In African countries, Lactuca capensis is traditionally used as vegetable and herbal remedy [17]. It has been reported that the leaves of Lactuca capensis are lightly boiled and eaten in Zimbabwe, while in Lesotho is used as a potherb as well as in Madagascar.…”

Section: Introductionmentioning

confidence: 99%

“…Among numerous herbal plants known to have medicinal value is Lactuca capensis Thunb., widespread in tropical Africa, Madagascar, South Africa and Yemen. Lactuca L. genus belongs to the family Asteraceae and comprises ~100 wild species [17]. In African countries, Lactuca capensis is traditionally used as vegetable and herbal remedy [17].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, Michalska and Kisiel [17] reported the presence of the coumarins scopolin, isofraxoside and a-xylofuranosyluracil in the roots and aerial parts of the Lactuca capensis. Scopolin was found to sustain memory formation, acetylcholine releasing from brain synaptosomes and induce long-term potentiation in the rat hippocampus [24].…”

Section: Introductionmentioning

confidence: 99%

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Lactuca capensis reverses memory deficits in Aβ1‐42‐induced an animal model of Alzheimer's disease

Postu

Noumedem

Cioancă

et al. 2017

J Cellular Molecular Medi

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We investigated the neuropharmacological effects of the methanolic extract from Lactuca capensis Thunb. leaves (100 and 200 mg/kg) for 21 days on memory impairment in an Alzheimer's disease (AD) rat model produced by direct intraventricular delivery of amyloid‐β1‐42 (Aβ1‐42). Behavioural assays such as Y‐maze and radial arm maze test were used for assessing memory performance. Aβ1‐42 decreased cognitive performance in the behavioural tests which were ameliorated by pre‐treatment with the methanolic extract. Acetylcholinesterase activity and oxidant–antioxidant balance in the rat hippocampus were abnormally altered by Aβ1‐42 treatment while these deficits were recovered by pre‐treatment with the methanolic extract. In addition, rats were given Aβ1‐42 exhibited in the hippocampus decreased brain‐derived neurotrophic factor (BDNF) mRNA copy number and increased IL‐1β mRNA copy number which was reversed by the methanolic extract administration. These findings suggest that the methanolic extract could be a potent neuropharmacological agent against dementia via modulating cholinergic activity, increasing of BDNF levels and promoting antioxidant action in the rat hippocampus.

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Section: Resultscontrasting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lactuca capensis reverses memory deficits in Aβ1‐42‐induced an animal model of Alzheimer's disease

Postu

Noumedem

Cioancă

et al. 2017

J Cellular Molecular Medi

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“…Furthermore, each fraction was also tested for toxicity using the Brine Shrimp Lethality Test (BSLT) method with Arthemia salia Lech as a bioindicator. Determination of LC50 to see the effectiveness of secondary metabolites was determined based on extrapolation of probit linear graphs at various concentrations of various concentrations [13,14,15].…”

Section: Secondary Matabolites Isolationmentioning

confidence: 99%

Phytochemical screening and secondary metabolites toxicity test from toba frankincense leaf (STYRAX paralleoncomud PERK)

Sitorus

Silaban

Susanti

et al. 2022

J. Phys.: Conf. Ser.

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The secondary metabolites of Toba frankincense leaf (STYRAX paralleoncomud PERK) have been isolated by maceration with n-Hexane, Ethyl acetate and Ethanol as solvents. The results of phytochemical screening of secondary metabolites in n-hexane extract were high amounts of flavonoids and steoids and low amounts of saponins and tannins, ethyl acetate extract were steroids and tannins in large amounts, moderate amounts of flavonoids and small amounts of saponins and extracts. ethanol, saponins and tannins in large quantities and small amounts of flavonoids. Alkaloids and terpenoids (essential oils) were not detected in the three extracts. It was concluded that the secondary metabolites in incense leaves were: flavonoids, saponins, steroids and tannins. Toxicity test of the three extracts was carried out using the Brine Shrimp Letality Test (BSLT) method with Arthemia salia Lech as a bioindicator with concentration variations: 10, 100, 500 and 1000 ppm. The test was carried out with three repetitions with 40 larvae of Arthemia salia Lech each. Toxicity test results obtained Inhibition Concentration ( IC50 ) of n-hexane extract was 1350.95 mg/L (non-toxic), ethyl acetate extract 18.98 mg/L (very toxic) and ethanol fraction 41.20 mg/L (moderate toxicity). Thus the secondary metabolites in the ethyl acetate extract are very potential as drug candidates, while the metabolites in the ethanol extract are quite potential.

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Secondary Metabolism in Tissue and Organ Cultures of Plants from the Tribe Cichorieae

Stojakowska

Malarz

2019

Reference Series in Phytochemistry

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Chemical constituents from Lactuca inermis, a wild African species

Cited by 11 publications

References 11 publications

Lactuca capensis reverses memory deficits in Aβ1‐42‐induced an animal model of Alzheimer's disease

Lactuca capensis reverses memory deficits in Aβ1‐42‐induced an animal model of Alzheimer's disease

Phytochemical screening and secondary metabolites toxicity test from toba frankincense leaf (STYRAX paralleoncomud PERK)

Secondary Metabolism in Tissue and Organ Cultures of Plants from the Tribe Cichorieae

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