<i>Lactuca capensis</i> reverses memory deficits in Aβ1‐42‐induced an animal model of Alzheimer's disease

Postu, Paula Alexandra; Noumedem, Jaurès A. K.; Cioancă, Oana; Hăncianu, Monica; Mihășan, Marius; Ciorpac, Mitică; Gorgan, Dragoș Lucian; Petre, Brînduşa Alina; Hrițcu, Lucian

doi:10.1111/jcmm.13299

Cited by 34 publications

(20 citation statements)

References 71 publications

(84 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the literature data [31,32] emphasizes that in patients diagnosed with Alzheimer's disease, irreversible brain disorder characterized mainly by cholinergic deficits, oxidative stress and mitochondrial dysfunctions [33], the target is to inhibit AChE activity in order to maintain acetylcholine levels in the neuronal synapses to obtain beneficial effects in patients with Alzheimer's disease [29].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Ceratonia Siliqua Methanolic Extract on 6-OHDA Zebrafish Model Antiacetylcholinesterase and Anxiolytic Profile

Hrițcu¹,

Abidar²,

Dumitru³

et al. 2019

Rev. Chim.

Self Cite

View full text Add to dashboard Cite

Anxiety and depression are the most common mental disorders that increase morbidity in the world, and recent data (World Health Organization - WHO) show that over 322 million people suffer from depression and anxiety, especially women being more exposed than men. 6-Hydroxydopamine (6-OHDA) is a catecholaminergic neurotoxin which is formed endogenously in patients diagnosed with Parkinson�s disease and has two mechanisms of action. Thus, it easily forms free radicals and is a potent inhibitor of the mitochondrial respiratory chain complexes I and IV. The treatments administration of 6-OHDA (160 �M) and Ceratonia siliqua L. methanolic extract (0.1 mg/mL, 0.3 mg/mL and 1.0 mg/mL) in Danio rerio specimens affected the acetylcholinesterase activity (AChE) and anxiolytic profile in close correlation with the dose of administered extract, the group with significant differences being the treated one with 6-OHDA alone.

show abstract

Section: Resultsmentioning

confidence: 99%

“…AChE was determined using acetylcholine as an artificial substrate, by spectrophotometric method with 2dinitrobenzoic acid (DTNB) to form a yellow colored complex having a maximum absorption at the wavelength of 412 nm [29]. The enzymatic activity was expressed as nmol/min·mg protein.…”

Section: Ache Assay Activitymentioning

confidence: 99%

Ceratonia Siliqua Methanolic Extract on 6-OHDA Zebrafish Model Antiacetylcholinesterase and Anxiolytic Profile

Hrițcu¹,

Abidar²,

Dumitru³

et al. 2019

Rev. Chim.

Self Cite

View full text Add to dashboard Cite

show abstract

“…26) Each mouse was anaesthetized with sodium pentobarbital (intraperitoneal administration at a dose of 70 mg/kg, Sigma, U.S.A) and fixed in a stereotaxic apparatus (Leica, Germany). According to the atlas by Paxinos and Franklin, 27) guide cannula was implanted into the right lateral ventricle (AP = 0.5 mm, RL = 1.0 mm, DV = 2.0 mm), or were implanted in the bilateral hippocampus CA1 region (AP = 2 mm, RL=±1.5 mm, DV = 1.2 mm). Each mouse was individually housed and allowed 5-7 d to recover after surgery.…”

Section: Methodsmentioning

confidence: 99%

Chemerin-9 Peptide Enhances Memory and Ameliorates Aβ<sub>1–42</sub>-Induced Object Memory Impairment in Mice

Lei

Xue

et al. 2020

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

Accumulating evidence suggests that the inhibition of neuroinflammation is a potential target for therapeutic or preventive strategies for Alzheimer's disease (AD). Chemerin has attracted particular attention for its role in the regulation of inflammation. In addition, amyloid β 1-42 (Aβ 1-42) can interact with chemokine-like receptor 1 (CMKLR1), the receptor for chemerin, and induce microglial chemotaxis. Meanwhile, CMKLR1 is expressed in the brain, and both chemerin and Aβ 1-42 share the same receptor. Thus, we hypothesized that chemerin (C9), a chemerin-derived nonapeptide, may have the potential to ameliorate Aβ 1-42 mediated AD disease progression. The results showed that an intracerebroventricular (i.c.v.) injection of C9 (8 µg/kg) facilitated memory formation and improved memory retention, as evidenced by the results of both the novel object recognition test (NOR) and object location recognition (OLR) tasks. These memory-enhancing effects of C9 were also observed after C9 (2 µg/kg) was infused into the hippocampus. Moreover, we found that treatment with C9 reversed the deficits in memory and learning ability induced by oligomeric Aβ 1-42. Meanwhile, C9 also significantly inhibited Aβ 1-42-induced increases in the levels of pro-inflammatory cytokines such as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in the hippocampus. The same results were obtained for Western blotting and enzyme-linked immunosorbent assay (ELISA) experiments. Finally, we observed that C9 did not affect locomotor activity, suggesting that its improvement of memory is not a false positive induced by hypolocomotion. In conclusion, C9 may facilitate memory formation, prolong memory retention, and ameliorate Aβ 1-42-induced memory impairment, suggesting that C9 may potentially represent a novel strategy for the treatment of AD.

show abstract

“…L. indica L. is used for its antibacterial and anti-inflammatory effects. L. capensis Thunb is used for treating sores, ulcers, leprosy, eczema, and the milky latex of L. virosa L., known as "lactucarium", is taken as a sedative-hypnotic [5][6][7]. Bioactivity studies on Lactuca species have shown that these plants have analgesic, anti-inflammatory, antioxidant, anticarcinogenic, hepatoprotective, neuroprotective, antidiabetic, and anxiolytic effects [8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Sedative Effects of Latexes Obtained from Some Lactuca L. Species Growing in Turkey

et al. 2020

View full text Add to dashboard Cite

Lactuca L. species belong to the Asteraceae family and these plants are traditionally used for therapeutic purposes around the world. The dried milky latex of L. serriola is known as “lettuce oil” and is used as a sedative in Turkey. This study aimed to evaluate the sedative effects and analyze the chemical compositions of latexes obtained from some Lactuca species growing in Turkey. The sedative effects were evaluated through various behavioral tests on mice. For this purpose, latexes were obtained from L. glareosa Boiss., L. viminea (L.) J. Presl and C. P, L. mulgedioides (Vis and Panćić) Boiss. and Kotschy ex. Boiss., L. saligna L., and L. serriola L. The latex from L. saligna showed the highest sedative effects, whilst L. serriola and L. viminea latexes also displayed significant sedative effects compared to the control group at a dose of 100 mg/kg. However, the latexes from L. glareosa and L. mulqedioides did not exhibit any sedative effects on mice. Characteristic sesquiterpene lactones (lactucin, lactucopicrin, 11,13β-dihydrolactucin, and 11,13β-dihydrolactucopicrin) were determined qualitatively and quantitatively by high-performance liquid chromatography (HPLC). Lactucin was identified as the main component.

show abstract

Lactuca capensis reverses memory deficits in Aβ1‐42‐induced an animal model of Alzheimer's disease

Cited by 34 publications

References 71 publications

Ceratonia Siliqua Methanolic Extract on 6-OHDA Zebrafish Model Antiacetylcholinesterase and Anxiolytic Profile

Ceratonia Siliqua Methanolic Extract on 6-OHDA Zebrafish Model Antiacetylcholinesterase and Anxiolytic Profile

Chemerin-9 Peptide Enhances Memory and Ameliorates Aβ<sub>1–42</sub>-Induced Object Memory Impairment in Mice

Sedative Effects of Latexes Obtained from Some Lactuca L. Species Growing in Turkey

Contact Info

Product

Resources

About