Chemical constituents from fruits of <i>Cnestis ferruginea</i> Vahl ex. DC (Connaraceae) and evaluation of their anticholinesterase and antiradical activities

Maleu, Thérèse Christelle; Talla, Rostan Mangoua; Kamdem, Michael Hermann Kengne; Tamfu, Alfred Ngenge; Küçükaydın, Selçuk; Mmutlane, Edwin Mpho; Ndinteh, Derek Tantoh; Mbazoa, Céline Djama; Wandji, Jean

doi:10.1080/14786419.2022.2048299

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…The cholinergic hypothesis suggests that inhibiting Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE) can relieve cholinergic functions by increasing the levels of acetylcholine in the synapse necessary for neurotransmission and this is a suitable strategy to overcome AD. [67,68] Various natural plant extracts, essential oils and compounds have been searched and reported as potential AChE and BChE inhibitors with higher efficacy and safety than synthetic drugs. [67,69] Inhibition of enzymes such as cholinesterase and carbohydrate enzymes like α-amylase and α-glucosidase are beneficial in the treatment of AD and diabetes.…”

Section: Discussionmentioning

confidence: 99%

HPLC-DAD Phenolic Composition, Antioxidant, Anticholinesterase, Antidiabetic and Anti-quorum Sensing Properties of Bitter Kola (Garcinia kola) and Kolanut (Cola acuminata)

Boudiba¹,

Küçükaydın²,

Tamfu³

et al. 2023

Pharmacogn. Res.

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Background: Eating Cola acuminata and Garcinia cola nuts in African societies symbolizes in socio-cultural hospitality. They stimulate the nervous system, reduce fatigue and sleep. Objectives: To determine the phenolic composition and bioactivities of G. kola and C. acuminata. Materials and Methods: Hydro-ethanol extracts of the nuts were prepared and their phenolic profiles determined using HPLC-DAD. Antioxidant, anticholinesterase, antidiabetic, antimicrobial, antibiofilm and anti-quorum sensing properties were determined. Results: The most abundant phenolic compound was caffeic acid (105.4±0.75 mg/g) in C. acuminata and myricetin (277.2±0.90 mg/g) in G. kola. The extracts showed good antioxidant activity in five complementary assays and G. kola was more active than both α-tocopherol and BHA standards in the DPPH • , CUPRAC and ABTS •+ assays while C. acuminata was more active than only the α-tocopherol standard in the same assays. Activities were close to those of standards in the β-Carotene-linoleic acid and metal chelation assays. Both extracts had good inhibition of Butyrylcholinesterase (BChE) and Acetylcholinesterase (AChE) with IC 50 values 63.27±0.98 µg/mL and 94.15±1.05 µg/mL for C. acuminata and G. kola respectively compared to 5.50±0.25 µg/mL for galantamine in the AChE assay. In the BChE assay, the inhibitory activity was higher for G. kola (IC 50 = 38.66±0.80 µg/ mL) that the standard galantamine (IC 50 = 42.20±0.48 µg/mL) while that for C. acuminata (IC 50 = 87.31±0.77 µg/mL) was moderate. The extracts inhibited α-amylase and α-glucosidase with G. kola (IC 50 =18.43±0.74 µg/mL) being more active than standard acarbose (IC 50 =20.52±0.84 µg/mL in the α-glucosidase assay. The nuts could inhibit expression of virulence factors in Chomobacterium violaceum CV12472 by disrupting violacein production and flagellated Pseudomonas aeruginosa PA01 by disrupting swarming motility. Conclusion: The results indicate good nutraceutical potential of both nuts.

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Section: Discussionmentioning

confidence: 99%

HPLC-DAD Phenolic Composition, Antioxidant, Anticholinesterase, Antidiabetic and Anti-quorum Sensing Properties of Bitter Kola (Garcinia kola) and Kolanut (Cola acuminata)

Boudiba¹,

Küçükaydın²,

Tamfu³

et al. 2023

Pharmacogn. Res.

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“…The tested extract and isolated compounds exhibited moderate-togood inhibitions for both AChE and BChE, indicating their pharmacological potential in terms of the palliation of the symptoms and treatment of AD, as well as possibly reducing the progression of the disease by interfering with the cholinergic system. The isolated compounds, which are diterpenoids, triterpene and sterols, are described as classes of secondary metabolites with potential cholinesterase inhibition due to their small molecular sizes, and can cross the blood–brain barrier and exercise physiological effects [ 15 , 44 , 45 , 46 ]. Though AD cannot be cured easily, its progression can be slowed down or stopped.…”

Section: Discussionmentioning

confidence: 99%

In Vitro and In Silico Evaluation of Anticholinesterase and Antidiabetic Effects of Furanolabdanes and Other Constituents from Graptophyllum pictum (Linn.) Griffith

Metiefeng,

Tamfu,

Fotsing Tagatsing

et al. 2023

Molecules

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Graptophyllum pictum is a tropical plant noticeable for its variegated leaves and exploited for various medicinal purposes. In this study, seven compounds, including three furanolabdane diterpenoids, i.e., Hypopurin E, Hypopurin A and Hypopurin B, as well as with Lupeol, β-sitosterol 3-O-β-d-glucopyranoside, stigmasterol 3-O-β-d-glucopyranoside and a mixture of β-sitosterol and stigmasterol, were isolated from G. pictum, and their structures were deduced from ESI-TOF-MS, HR-ESI-TOF-MS, 1D and 2D NMR experiments. The compounds were evaluated for their anticholinesterase activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BchE), as well as their antidiabetic potential through inhibition of α-glucosidase and α-amylase. For AChE inhibition, no sample had IC50 within tested concentrations, though the most potent was Hypopurin A, which had a percentage inhibition of 40.18 ± 0.75%, compared to 85.91 ± 0.58% for galantamine, at 100 µg/mL. BChE was more susceptible to the leaves extract (IC50 = 58.21 ± 0.65 µg/mL), stem extract (IC50 = 67.05 ± 0.82 µg/mL), Hypopurin A (IC50 = 58.00 ± 0.90 µg/mL), Hypopurin B (IC50 = 67.05 ± 0.92 µg/mL) and Hypopurin E (IC50 = 86.90 ± 0.76 µg/mL). In the antidiabetic assay, the furanolabdane diterpenoids, lupeol and the extracts had moderate to good activities. Against α-glucosidase, lupeol, Hypopurin E, Hypopurin A and Hypopurin B had appreciable activities but the leaves (IC50 = 48.90 ± 0.17 µg/mL) and stem (IC50 = 45.61 ± 0.56 µg/mL) extracts were more active than the pure compounds. In the α-amylase assay, stem extract (IC50 = 64.47 ± 0.78 µg/mL), Hypopurin A (IC50 = 60.68 ± 0.55 µg/mL) and Hypopurin B (IC50 = 69.51 ± 1.30 µg/mL) had moderate activities compared to the standard acarbose (IC50 = 32.25 ± 0.36 µg/mL). Molecular docking was performed to determine the binding modes and free binding energies of Hypopurin E, Hypopurin A and Hypopurin B in relation to the enzymes and decipher the structure–activity relationship. The results indicated that G. pictum and its compounds could, in general, be used in the development of therapies for Alzheimer’s disease and diabetes.

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Phenolic profiles, antioxidant, antiquorum sensing, antibiofilm and enzyme inhibitory activities of selected Acacia species collected from Benin

Alain¹,

Tamfu²,

Küçükaydın³

et al. 2022

LWT

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Chemical constituents from fruits of Cnestis ferruginea Vahl ex. DC (Connaraceae) and evaluation of their anticholinesterase and antiradical activities

Cited by 3 publications

References 22 publications

HPLC-DAD Phenolic Composition, Antioxidant, Anticholinesterase, Antidiabetic and Anti-quorum Sensing Properties of Bitter Kola (Garcinia kola) and Kolanut (Cola acuminata)

HPLC-DAD Phenolic Composition, Antioxidant, Anticholinesterase, Antidiabetic and Anti-quorum Sensing Properties of Bitter Kola (Garcinia kola) and Kolanut (Cola acuminata)

In Vitro and In Silico Evaluation of Anticholinesterase and Antidiabetic Effects of Furanolabdanes and Other Constituents from Graptophyllum pictum (Linn.) Griffith

Phenolic profiles, antioxidant, antiquorum sensing, antibiofilm and enzyme inhibitory activities of selected Acacia species collected from Benin

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