Chemical Constituents and Preliminary Antimalarial Activity ofHumiria balsamifera

Abstract

From stems and leaves of Humiria balsamifera St. (Aubl.) Hill (Humiriaceae) were isolated 6 triterpenes [arjunolic acid, 2b,3a-dihydroxy-D:A-friedooleanane, friedelin, a-and bamyrins and lupeol], a flavonol (quercetin), an isocoumarin (bergenin) a diterpene (phytol), and 2 phytosteroids (sitosterol and stigmasterol)]. Three sesquiterpenoids [caryophyllene oxide (0.9%), humulene epoxide II (0.3%) and trans-isolongifolenone (0.6%)], a diterpene [phytol (29.4%)] and four aliphatic esters [methyl tetra-(0.3%), hexa-(26.6%) and octadecanoate (0.3%), and ethyl tetradecanoate (26.9%)] were identified by GC/MS. Some crude extracts, arjunolic acid and bergenin, were screened in vivo and/or in vitro for their antimalarial activities against a chloroquine resistant strain. Structures of all isolated compounds were elucidated by spectroscopic analysis, including 2D NMR experiments. All isolates, with the exception of the isocoumarin bergenin, and identified compounds as well as antimalarial activities, are described for the first time for this species.

Towards the optimization of botanical insecticides research: Aedes aegypti larvicidal natural products in French Guiana

“…H. balsamifera is a large tree common in Amazonia and North-East Brazil. Numerous compounds were isolated from this species, including trans-isolongifolenone (Da Silva et al 2004). 48 Interestingly, a repulsive effect of this compound was described on Ae.…”

Isolongifolenone: A Novel Sesquiterpene Repellent of Ticks and Mosquitoes

“…(Aubl.) Hill (Humiriaceae), a plant commonly found in South America (Da Silva et al 2004). Isolongifolenone is odorless and some of its derivatives have a characteristic woody smell (Hall 1973, Pickenhagen and Schatkowski 2002, De Bruyn et al 2003.…”

Antimalarial activity of extract and norbergenin derivatives from the stem bark of Diospyros sanza‐minika A. Chevalier (Ebenaceae)

“…Several studies have indeed documented the antimalarial potency of crude extracts from the genus Diospyros as well as that of some of their antimalarial constituents (Likhitwitayawuid et al, 1999;Ma et al, 2008;Kantamreddi and Wright, 2008), which were generally found to be triterpenes such as betulinic acid 3-caffeate from Diospyros quaesita (Ma et al, 2008) and naphthoquinones such as diospyrin from Diospyros montana (Likhitwitayawuid et al, 1999). Bergenin, an isocoumarin previously isolated from Diospyros sanza-minika (Musgrave and Skoyles, 1974) was found to be inactive against P. falciparum and only weakly active against P. berghei (Silva et al, 2004). Compound 1, a methyl derivative of bergenin, was inactive.…”