Towards the optimization of botanical insecticides research: Aedes aegypti larvicidal natural products in French Guiana

Falkowski, Michaël; Jahn-Oyac, Arnaud; Odonne, Guillaume; Flora, Claudiane; Estevez, Yannick; Touré, Seindé; Boulogne, Isabelle; Robinson, Jean-Charles; Béreau, Didier; Petit, Philippe; Coke, Maïra; Issaly, Jean; Gaborit, Pascal; Stien, Didier; Éparvier, Véronique; Dusfour, Isabelle; Houël, Emeline

doi:10.1016/j.actatropica.2019.105179

Cited by 20 publications

(17 citation statements)

References 81 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Natural products provide a viable option to keep pace with vector adaptability and associated resistance ( Falkowski et al, 2020 ). Thus, efforts are ongoing in the exploration of biodiversity to source new extracts or active compounds.…”

Section: Challenges For Np-based Productsmentioning

confidence: 99%

Challenges, Advances and Opportunities in Exploring Natural Products to Control Arboviral Disease Vectors

Demarque

Espindola

2021

Front. Chem.

View full text Add to dashboard Cite

Natural products constitute an important source of molecules for product development. However, despite numerous reports of compounds and active extracts from biodiversity, poor and developing countries continue to suffer with endemic diseases caused by arboviral vectors, including dengue, Zika, chikungunya and urban yellow fever. Vector control remains the most efficient disease prevention strategy. Wide and prolonged use of insecticides has resulted in vector resistance, making the search for new chemical prototypes imperative. Considering the potential of natural products chemistry for developing natural products-based products, including insecticides, this contribution discusses the general aspects and specific characteristics involved in the development of drug leads for vector control. Throughout this work, we highlight the obstacles that need to be overcome in order for natural products compounds to be considered promising prototypes. Moreover, we analyze the bottlenecks that should be addressed, together with potential strategies, to rationalize and improve the efficiency of the drug discovery process.

show abstract

Section: Challenges For Np-based Productsmentioning

confidence: 99%

Challenges, Advances and Opportunities in Exploring Natural Products to Control Arboviral Disease Vectors

Demarque

Espindola

2021

Front. Chem.

View full text Add to dashboard Cite

show abstract

“…S. leucocarpon seems not to have been tested for antimalarial/antiplasmodial activities. No toxicity has been observed in an Artemia assay (Correa et al, 2011), nor on Aedes aegypti (Falkowski et al, 2019). An E. triplinerve MeOH extract displayed an IC 50 of 36µg/mL in vitro on P. falciparum and no toxicity on A-549 cell lines (Jonville et al, 2011), although it was considered inactive (same solvent, IC 50 >50µg/mL) a few years ago (Jonville et al, 2008).…”

Section: Ethnopharmacology Of Cited Speciesmentioning

confidence: 99%

When local phytotherapies meet biomedicine. Cross-sectional study of knowledge and intercultural practices against malaria in Eastern French Guiana

Odonne

Musset

Cropet

et al. 2021

Journal of Ethnopharmacology

View full text Add to dashboard Cite

“…However, vector control relies primarily on chemical insecticides with very few targets, and these insecticides have recently been increasingly associated with greater resistance, off-target toxicity and long-lasting persistence in nature [ 8 ]. Natural products (NP), commonly secondary metabolites produced by bacteria, plants or fungi, are considered a promising alternative to synthetic insecticidal compounds with respect to these concerns [ 8 , 9 ]. The generally lesser toxicity and environmental effects of biopesticides have been addressed in the agricultural sector where the need for alternative methods, and thus the interest in biopesticides, has greatly increased [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Discovery of novel natural products for mosquito control

2022

View full text Add to dashboard Cite

Vector control plays a key role in reducing the public health burden of mosquito-borne diseases. Today’s vector control strategies largely rely on synthetic insecticides that can have a negative environmental impact when applied outdoors and often become inefficient because of the mosquitoes’ ability to develop resistance. An alternative and promising approach to circumvent these challenges involves the implementation of insecticides derived from nature (biopesticides) for vector control. Biopesticides can constitute naturally occurring organisms or substances derived from them that have lifespan-shortening effects on disease vectors such as mosquitoes. Here we present the discovery and evaluation of natural product-based biological control agents that can potentially be developed into biopesticides for mosquito control. We screened a natural product collection comprising 390 compounds and initially identified 26 molecules with potential ability to kill the larval stages of the yellow fever mosquito Aedes aegypti, which is responsible for transmitting viruses such as dengue, Zika, chikungunya and yellow fever. Natural products identified as hits in the screen were further evaluated for their suitability for biopesticide development. We show that a selection of the natural product top hits, bactobolin, maytansine and ossamycin, also killed the larval stages of the malaria-transmitting mosquito Anopheles gambiae as well as the adult form of both species. We have further explored the usefulness of crude extracts and preparations from two of the best candidates’ sources (organisms of origin) for mosquitocidal activity, that is extracts from the two bacteria Burkholderia thailandensis and Streptomyces hygroscopicus var. ossamyceticus. Graphical abstract

show abstract

Towards the optimization of botanical insecticides research: Aedes aegypti larvicidal natural products in French Guiana

Abstract: Please note that this is an author-produced PDF of an article accepted for publication following peer review. The definitive publisher-authenticated version is available on the publisher Web site.

Cited by 20 publications

References 81 publications

Challenges, Advances and Opportunities in Exploring Natural Products to Control Arboviral Disease Vectors

Challenges, Advances and Opportunities in Exploring Natural Products to Control Arboviral Disease Vectors

When local phytotherapies meet biomedicine. Cross-sectional study of knowledge and intercultural practices against malaria in Eastern French Guiana

Discovery of novel natural products for mosquito control

Contact Info

Product

Resources

About