Chemical composition of essential oils from different parts of <i>Protium heptaphyllum</i> (Aubl.) Marchand and their <i>in vitro</i> antibacterial activity

Cabral, Rodrigo Sebastião Cruvinel; Alves, Cássia Cristina Fernandes; Batista, Hellen Regina Fernandes; Sousa, Wendel Cruvinel de; Abrahão, Isabela S; Crotti, Antônio Eduardo Miller; Santiago, Mariana Brentini; Martins, Carlos Henrique Gomes; Miranda, Mayker Lázaro Dantas

doi:10.1080/14786419.2018.1536659

Cited by 18 publications

(10 citation statements)

References 26 publications

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“…Although antibacterial activity has previously been described in B. crassifolia, Pro. heptaphyllum, and Xylopia aromatica [20][21][22][23][24], we found that only some of the plant part extracts inhibited both M. tuberculosis growth and the kinase activity. e flower extract of B. crassifolia had an IC 50 of 30.4 μg/ml and an MIC of 500 μg/ml, while the inner bark extract showed an IC 50 of 144 μg/ml but an MIC higher than 500 μg/ml.…”

Section: Discussionmentioning

confidence: 73%

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Antimycobacterial and PknB Inhibitory Activities of Venezuelan Medicinal Plants

Aranaga

Fraile

Torres

et al. 2020

International Journal of Microbiology

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Global control and elimination of tuberculosis are hindered by the high prevalence of drug-resistant strains, making the development of new drugs to fight tuberculosis a public health priority. In this study, we evaluated 118 extracts from 58 Venezuelan plant species for their ability to inhibit the growth of Mycobacterium tuberculosis mc26020, using the agar dilution method. Additionally, we determined the ability of these extracts to inhibit the activity of PknB protein, an essential M. tuberculosis serine/threonine kinase, using a high-throughput luminescent assay. Of the 118 extracts tested, 14 inhibited bacterial growth with a minimum inhibitory concentration ≤500 μg/ml, and 36 inhibited the kinase activity with a half-maximal inhibitory concentration <200 μg/ml. Five extracts inhibited M. tuberculosis growth and inhibited the activity of the kinase protein, suggesting that this could be the basis of their growth inhibition.

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Section: Discussionmentioning

confidence: 73%

“…Phytochemical studies of the essential oils of X. aromatica and Prot. heptaphyllum leaves demonstrated the presence of various terpenes, including spathulenol [ 20 , 21 ]. This sesquiterpene has been shown to have antibacterial activity against Cryptococcus neoformans , Enterococcus faecalis , and Staphylococcus aureus [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Antimycobacterial and PknB Inhibitory Activities of Venezuelan Medicinal Plants

Aranaga

Fraile

Torres

et al. 2020

International Journal of Microbiology

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“…Several essential oil compounds have high potential on antibacterial activity and these compounds are monoterpenic, sesquiterpenic and phenylpropanoid with proven action as limonene (Goulart et al, 2018), thymol (Majolo et al, 2020), germacrene D (Freitas et al, 2020), caryophyllene and α-pinene (Nelson, 2019), β-bisabolene (Mazaheritehrani et al, 2021) and myrcene (Cabral et al, 2020). The cytotoxic assay on A. salina showed LC 50 = 90.17 ± 1.90b and 625.08 ± 2.88c µg mL -1 for the essential oil of fresh leaves and xylopodium of C. regium.…”

Section: Resultsmentioning

confidence: 99%

Chemical profile and antioxidant, antibacterial, and cytotoxic activities on Artemia salina from the essential oil of leaves and xylopodium of Cochlospermum regium

Magalhães¹,

Filho

Ventura

et al. 2021

Sci. Elec. Arch.

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Cochlospermum regium is a shrub plant species from the Cerrado domain used in traditional medicine. This study aimed to evaluate the chemical profile and antioxidant, antibacterial and cytotoxic activities on Artemia salina from the essential oil of fresh leaves and xylopodium. Fresch leaves and xylopodium of C. regium were collected in an area of Cerrado domain in Goiás State, Brazil, 2021. The essential oil was obtained by hydrodistillation, the yield was quantified and the chemical profile determined by gas chromatography with mass spectrometry (GC-MS). Physicochemical analyzes were carried out for organoleptic analysis (color and appearance), solubility, relative density (g mL-1), refractive index, optical rotation (αD), antioxidant activity in DPPH radical reduction (IC50 µL mL-1), antibacterial activity on Escherichia coli, Staphylococcus aureus, Enterococcus faecalis, Salmonella serovar Enteritidis and Salmonella serovar Thyphymurium by the disc method (mm), and cytotoxicity bioassay on Artemia salina (LC50 µg mL-1). The major compounds for the essential oil of fresh leaves were viridiflorol 10.21%, Copaen-4-α-ol <β>, longiborneol 9.07 and β-bisabolene 11.48%, and for the essential oil of xylopodium β-selinene 26.17%, aromadendrene 8.66 % and thujopsene 8.09%. The yield was 0.58 and 0.33%, color slightly yellow and yellow for fresh leaves and xylopodium, respectively. Positive solubility, refractive index of 1.3468 and 1.3347, optical rotation +48.8 and +21.5, relative density 0.932 and 0.936 g mL-1, antioxidant activity IC50 = 47.65 and 111.16 µL mL-1 for fresh leaves essential oil and xylopodium, respectively. The essential oil from fresh leaves showed high antibacterial potential for all strains, as well as for cytotoxic activity on A. salina with LC50 = 90.17 and 625.08 µg mL-1, respectively.

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“…However, the mechanisms involved in the observed anti-inflammatory action were not clarified. More recently, antibacterial activity [36][37][38] and effects on blood sugar level and lipid profile have also been highlighted for the essential oil obtained from P. heptaphyllum gum resin [39][40][41]. The observed effects on lipid metabolism involved a decrease of total cholesterol, LDL-C, serum triglycerides, and VLDL, with an elevation of high-density lipoprotein cholesterol (HDL-C).…”

Section: Introductionmentioning

confidence: 99%

Bioactive Triterpenes of Protium heptaphyllum Gum Resin Extract Display Cholesterol-Lowering Potential

Mannino

Iovino²,

Lauria

et al. 2021

IJMS

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Hypercholesterolemia is one of the major causes of cardiovascular disease, the risk of which is further increased if other forms of dyslipidemia occur. Current therapeutic strategies include changes in lifestyle coupled with drug administration. Statins represent the most common therapeutic approach, but they may be insufficient due to the onset of resistance mechanisms and side effects. Consequently, patients with mild hypercholesterolemia prefer the use of food supplements since these are perceived to be safer. Here, we investigate the phytochemical profile and cholesterol-lowering potential of Protium heptaphyllum gum resin extract (PHE). Chemical characterization via HPLC-APCI-HRMS2 and GC-FID/MS identified 13 compounds mainly belonging to ursane, oleanane, and tirucallane groups. Studies on human hepatocytes have revealed how PHE is able to reduce cholesterol production and regulate the expression of proteins involved in its metabolism. (HMGCR, PCSK9, LDLR, FXR, IDOL, and PPAR). Moreover, measuring the inhibitory activity of PHE against HMGR, moderate inhibition was recorded. Finally, molecular docking studies identified acidic tetra- and pentacyclic triterpenoids as the main compounds responsible for this action. In conclusion, our study demonstrates how PHE may be a useful alternative to contrast hypercholesterolemia, highlighting its potential as a sustainable multitarget natural extract for the nutraceutical industry that is rapidly gaining acceptance as a source of health-promoting compounds.

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Chemical composition of essential oils from different parts of Protium heptaphyllum (Aubl.) Marchand and their in vitro antibacterial activity

Cited by 18 publications

References 26 publications

Antimycobacterial and PknB Inhibitory Activities of Venezuelan Medicinal Plants

Antimycobacterial and PknB Inhibitory Activities of Venezuelan Medicinal Plants

Chemical profile and antioxidant, antibacterial, and cytotoxic activities on Artemia salina from the essential oil of leaves and xylopodium of Cochlospermum regium

Bioactive Triterpenes of Protium heptaphyllum Gum Resin Extract Display Cholesterol-Lowering Potential

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