Chemical composition of Dracocephalum heterophyllum

Numonov, Sodik; Usmanova, S. K.; Aisa, Haji Akber

doi:10.1007/s10600-013-0654-5

Cited by 14 publications

(13 citation statements)

References 3 publications

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“…The structures of all isolated compounds were elucidated by analyzing their spectral data (MS, 1 H- and 13 C-NMR, including HMQC, HMBC and DEPT) and by comparison with published literature data. They were thus identified as 3,3′,4,4′-tetra- O -methylellagic acid [ 10 ], 3,3′-di- O -methylellagic acid [ 11 ], caffeic acid [ 12 ], quercetin [ 13 ], (+)-catechin [ 14 ], (–)-epicatechin [ 13 ], (–)-epigallocatechin [ 15 ], gallic acid [ 16 ], β-sitosterol-3- O -β- d -glucopyranoside [ 17 ] and corilagin [ 18 ] ( Figure 2 ).…”

Section: Resultsmentioning

confidence: 99%

Evaluation of the Antidiabetic Activity and Chemical Composition of Geranium collinum Root Extracts—Computational and Experimental Investigations

et al. 2017

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The root of Geranium collinum Steph is known in Tajik traditional medicine for its hepatoprotective, antioxidant, and anti-inflammatory therapeutic effects. The present study was conducted to evaluate of potential antidiabetic, antioxidant activities, total polyphenolic and flavonoid content from the different extracts (aqueous, aqueous-ethanolic) and individual compounds isolated of the root parts of G. collinum. The 50% aqueous-ethanolic extract possesses potent antidiabetic activity, with IC50 values of 0.10 μg/mL and 0.09 μg/mL for the enzymes protein-tyrosine phosphatase (1B PTP-1B) and α-glucosidase, respectively. Phytochemical investigations of the 50% aqueous-ethanolic extract of G. collinum, led to the isolation of ten pure compounds identified as 3,3′,4,4′-tetra-O-methylellagic acid (1), 3,3′-di-O-methylellagic acid (2), quercetin (3), caffeic acid (4), (+)-catechin (5), (–)-epicatechin (6), (–)-epigallocatechin (7), gallic acid (8), β-sitosterol-3-O-β-d-glucopyranoside (9), and corilagin (10). Their structures were determined based on 1D and 2D NMR and mass spectrometric analyses. Three isolated compounds exhibited strong inhibitory activity against PTP-1B, with IC50 values below 0.9 μg/mL, more effective than the positive control (1.46 μg/mL). Molecular docking analysis suggests polyphenolic compounds such as corilagin, catechin and caffeic acid inhibit PTP-1B and β-sitosterol-3-O-β-d-gluco-pyranoside inhibits α-glucosidase. The experimental results suggest that the biological activity of G. collinum is related to its polyphenol contents. The results are also in agreement with computational investigations. Furthermore, the potent antidiabetic activity of the 50% aqueous-ethanolic extract from G. collinum shows promise for its future application in medicine. To the best of our knowledge, we hereby report, for the first time, the antidiabetic activity of G. collinum.

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Section: Resultsmentioning

confidence: 99%

Evaluation of the Antidiabetic Activity and Chemical Composition of Geranium collinum Root Extracts—Computational and Experimental Investigations

et al. 2017

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“…They are the group of compounds which received considerable attention from the researchers as depicted from the scientific literature. Mostly, they are present in plants as glycosides but can also be isolated in free aglycon form [7,8].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Profiling and Evaluation of Pharmacological Activities of Hypericum scabrum L.

et al. 2015

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Phytochemical investigations of ethyl acetate-soluble part of the aerial part of Hypericum scabrum L. delivered eight pure phenolic compounds 1-8. The pure compounds were identified through physico-chemical, NMR (1D, 2D) and mass spectrometric studies as: 3-8′′-bisapigenin (1), quercetin (2), quercetin (7), (+)-catechin (8). Total polyphenolic compounds and total flavonoids contents were determined in the extract as 0.107 mg·mg of the dried extract, respectively. Antioxidant activity using DPPH free radical scavenging assay delivered very strong activity for compounds 2 and 5, 6 and crude extract 10. Protein tyrosine phosphatase 1B (PTP-1B) inhibition experiment of isolated OPEN ACCESSMolecules 2015, 20 11258 compounds and crude extracts resulted in significant inhibition activity for samples 2, 7a, 8a, 11 and 12 with IC50 values ranging from 1.57 to 2.91 µM. Antimicrobial activity of the pure compounds and extracts produced average results against Staphylococcus aureus, Escherichia coli and Candida albicans strains. From our literature survey, it appears that all pure compounds except 2 were isolated and reported for the first time in H. scabrum.

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“…All these data proved that compound (8) can be identified as 5, 7, 5'-trihydroxy-3'-methoxy-flavone 4'-O-glucoside. 39 All the structures of the isolated and identified compounds were shown in Fig.-1.…”

Section: Compound (6): Apigenin 5-o-rhamnosidementioning

confidence: 99%

"INVESTIGATION OF SOME CHEMICAL CONSTITUENTS, CYTOTOXICITY AND ANTIOXIDANT ACTIVITIES OF Beta Vulgaris var. altissima CULTIVATED IN EGYPT "

2017

RJC

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The phenolic compounds were isolated for the first time from the alcoholic extract of the non-flowering aerial parts of Beta vulgaris var. altissima (sugar beet) and were identified as: Apigenin, Luteolin, Apigenin 7-O-di-glucoside, Luteolin 4'-O-rhamnoside, Caffeoyl-6-(3,4-dihydroxy benzoyl) β-D-glucoside, Apigenin 5-O-rhamnoside, Isoscutellarein 7-O-glucosyl-8-O-xyloside and 5, 7, 5'-trihydroxy-3'-methoxy flavone 4'-O-glucoside. The structures of the isolated compounds were elucidated through chromatographic and spectroscopic measurements. The n-hexane extract of the plant was fractionated to fatty acid methyl esters and unsaponifiable matter. The gas-liquid chromatography analysis of fatty acids methyl esters proved the presence of 13 fatty acids of which eicosenoic acid C20:1 (41.38%) was the main acid, while the gas liquid chromatography of the unsaponifiable matter substantiated the presence of a mixture of 28 components in which campesterol (23.85%), n-triacontane C30 (12.71%) and cholesterol (8.77%) were the major components. The ethyl acetate fraction exhibited the highest antioxidant activity (62.65%) with effective concentration 57.2 µg/ml using radical scavenging activity. The percent proliferation of human hepatocellular carcinoma was reduced to 69.5% and 72.4% on treatment with the ethyl acetate and the methanol extracts respectively at concentration 100 µg/ml.

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Chemical composition of Dracocephalum heterophyllum

Cited by 14 publications

References 3 publications

Evaluation of the Antidiabetic Activity and Chemical Composition of Geranium collinum Root Extracts—Computational and Experimental Investigations

Evaluation of the Antidiabetic Activity and Chemical Composition of Geranium collinum Root Extracts—Computational and Experimental Investigations

Phytochemical Profiling and Evaluation of Pharmacological Activities of Hypericum scabrum L.

"INVESTIGATION OF SOME CHEMICAL CONSTITUENTS, CYTOTOXICITY AND ANTIOXIDANT ACTIVITIES OF Beta Vulgaris var. altissima CULTIVATED IN EGYPT "

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