Chemical Composition of Cinnamomum verum Leaf and Flower Essential Oils and Analysis of Their Antibacterial, Insecticidal, and Larvicidal Properties

Narayanankutty, Arunaksharan; Kunnath, Krishnaprasad; Alfarhan, Ahmed; Rajagopal, Rajakrishnan; Ramesh, Venkat

doi:10.3390/molecules26206303

Cited by 31 publications

(18 citation statements)

References 48 publications

(50 reference statements)

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“…Phytocompounds, which are functional components found in plants, have potent chemopreventive properties. Literature searches have been carried out to pinpoint the phytocompounds found in the selected plants, and we make a list of them 14–16 . The PubChem archive (https://pubchem.ncbi.nlm.nih.gov, viewed on 11 November 2022) provided the canonical SMILES for the list of phytocompounds (Table S1).…”

Section: Methodsmentioning

confidence: 99%

Cheminformatics and systems pharmacology approaches to unveil the potential plant bioactives to combat COVID‐19

Muralitharan,

Varadharajan,

Venkidasamy

2023

J of Molecular Recognition

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COVID‐19 was a global pandemic in the year 2020. Several treatment options failed to cure the disease. Thus, plant‐based medicines are becoming a trend nowadays due to their less side effects. Bioactive chemicals from natural sources have been utilised for centuries as treatment options for a variety of ailments. To find out the potent bioactive compounds to counteract COVID‐19, we use systems pharmacology and cheminformatics. They use the definitive data and predict the possible outcomes. In this study, we collected a total of 72 phytocompounds from the medicinally important plants such as Garcinia mangostana and Cinnamomum verum, of which 13 potential phytocompounds were identified to be active against the COVID‐19 infection based on Swiss Target Prediction and compound target network analysis. These phytocompounds were annotated to identify the specific human receptor that targets COVID‐19‐specific genes such as MAPK8, MAPK14, ACE, CYP3A4, TLR4 and TYK2. Among these, compounds such as smeathxanthone A, demethylcalabaxanthone, mangostanol, trapezifolixanthone from Garcinia mangostana and camphene from C. verum were putatively target various COVID‐19‐related genes. Molecular docking results showed that smeathxanthone A and demethylcalabaxanthone exhibit increased binding efficiency towards the COVID‐19‐related receptor proteins. These compounds also showed efficient putative pharmacoactive properties than the commercial drugs ((R)‐remdesivir, favipiravir and hydroxychloroquine) used to cure COVID‐19. In conclusion, our study highlights the use of cheminformatics approach to unravel the potent and novel phytocompounds against COVID‐19. These phytocompounds may be safer to use, more efficient and less harmful. This study highlights the value of natural products in the search for new drugs and identifies candidates with great promise.

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Section: Methodsmentioning

confidence: 99%

Cheminformatics and systems pharmacology approaches to unveil the potential plant bioactives to combat COVID‐19

Muralitharan,

Varadharajan,

Venkidasamy

2023

J of Molecular Recognition

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“…Clinical isolates of Gram-positive bacteria (Staphylococcus aureus, Bacillus cereus, and Listeria monocytogenes) and Gram negative bacteria (Escherichia coli, Salmonella typhi, and Shigella boydii) were propagated in a nutrient broth at 37 °C for 24 h before being tested for antibacterial activity but tested isolates for antifungal activity were Aspergillus niger and Candida albicans which were cultivated in potato dextrose broth for 48 hours at 28 °C. To determine the antimicrobial activity of the test substances, the diameters of the zone of inhibition in millimeters was measured using a modified Kirby-Bauer disc diffusion method (Narayanankutty et al, 2021a;Narayanankutty et al, 2021b). Filter discs soaked with 10 > l of sterilized water served as a negative control for antimicrobial activity, while standard discs of Gentamycin (antibacterial agent) and Nystatin (antifungal agent) served as positive controls.…”

Section: Test Bacteriamentioning

confidence: 99%

Influence of Foliar Application of Gibberellic Acid and Liquorice Root Extract on Growth, Volatile Oil Yield Productivity and Antimicrobial Activity in Geranium (Pelargonium Graveolens L. Her.) Plants

Abdel-Mola

Kenawy²,

Ali³

et al. 2022

Scient. J. of Flowers and Ornament. Plants

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This work was carried out during the two successive seasons (2019/2020 and 2020/2021) in the Experimental Farm of Horticulture Research Station at Sids, Beni-Suef Governorate, to investigate the effect of foliar application of gibberellic acid (GA3) at 100, 200 and 300 ppm and spraying of two extractions of liquorice root (aqueous LRE at 5 and 10 g/l and ethanolic LRE at 5 and 10 g/l) and their interaction on the vegetative growth (plant height, number of branches, herb fresh weight per plant and per feddan), volatile oil productivity (oil %, yield per plant and per feddan), total chlorophyll and total carbohydrates, NPK percentages, as well as antimicrobial activity of geranium plants. Obtained results revealed that the best vegetative growth characteristics, volatile oil productivity, total chlorophyll and carbohydrates were obtained due to the use of the high dose (300 ppm) and medium dose (200 ppm) of gibberellic acid with no significant differences between them. Concerning liquorice root extract treatments, all of the prementioned growth parameters, oil yield and chemical traits were considerably augmented due to the high dose of aqueous LRE at 10 g/l treatment followed by ethanolic LRE at 10 g/l, while LRE aqu. at 5 g/l gave the least values. In regard to the interaction between the two studied factors, the highest growth, yield and chemical composition values were given by GA3 at 200 or 300 ppm in combination with LRE aqu. at 10 g/l. Overall, the most powerful antimicrobial activity was recorded of the combination treatment in the two geranium cuts. Therefore, it could be advised from the economical and environmental point of view, to supply geranium plants with GA3 at 200 ppm and LRE aqu. at 10 g/l to improve the volatile oil yield and the antimicrobial activity.

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“…C. verum essential oil is used for its antimicrobial and larvicidal effects . Previous studies using C.…”

Section: Introductionmentioning

confidence: 99%

Enzyme-Based Antiviral Potential of Cinnamomum verum J. Presl. Essential Oil and Its Major Component (E)-Cinnamaldehyde

Karadağ,

Biltekin,

Ghani

et al. 2024

ACS Omega

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In the present study, Cinnamomum verum J. Presl. bark essential oil and its main component cinnamaldehyde was evaluated in vitro for neuraminidase (NA), transmembrane serine protease (TMPRSS2), and angiotensin converting enzyme 2 (ACE2) inhibitory activities. The chemical composition of C. verum essential oil was confirmed by both gas chromatography−mass spectrometry (GC/MS), and gas chromatography−flame ionization detection (GC-FID), where 75.9% (E)-cinnamaldehyde was the major component. The ACE2, NA, and TMPRSS2 enzyme inhibitions of C. verum bark essential oil at 20 μg/ mL concentration, and (E)-cinnamaldehyde (5 μg/mL) were calculated and compared in the range of 54.2−89.9%. Molecular docking results supported that (E)-cinnam-aldehyde was specific to ACE2 with 89.9% inhibition. Our findings suggest further in vivo studies to confirm the effective and safe use of the essential oil as well as the (E)-cinnamaldehyde.

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Chemical Composition of Cinnamomum verum Leaf and Flower Essential Oils and Analysis of Their Antibacterial, Insecticidal, and Larvicidal Properties

Cited by 31 publications

References 48 publications

Cheminformatics and systems pharmacology approaches to unveil the potential plant bioactives to combat COVID‐19

Cheminformatics and systems pharmacology approaches to unveil the potential plant bioactives to combat COVID‐19

Influence of Foliar Application of Gibberellic Acid and Liquorice Root Extract on Growth, Volatile Oil Yield Productivity and Antimicrobial Activity in Geranium (Pelargonium Graveolens L. Her.) Plants

Enzyme-Based Antiviral Potential of Cinnamomum verum J. Presl. Essential Oil and Its Major Component (E)-Cinnamaldehyde

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