Chemical Composition, Cytotoxic, Antimicrobial and Antioxidant Activities of Essential oil from Anthriscus caucalis M. Bieb Grown in China

Abstract

The essential oil of the aerial parts of Anthriscus caucalis M. Bieb was obtained by hydrodistillation and its components were analyzed by using GC and GC-MS. Forty-six compounds representing 97.2% of the total oil were identified. The main constituents in the oil were identified as β-Bisabolene (28.4%), Germacrene D (18.9%), (Z, E)-α-Farnesene (16.8%) and γ-Muurolene (7.3%). In vitro cytotoxicity evaluation against two cell lines of HepG2 (liver hepatocellular cells) and MCF-7 (human breast adenocarcinoma) cells showed a potent cytotoxic activity with the IC 50 values of 67.50 μg/mL and 55.83 μg/mL according to the MTT assay. Furthermore, the essential oil exhibited a considerable activity against Bacillus subtilis and Escherichia coli with the MIC values of 0.095 mg/mL and 0.105 mg/mL tested by micro-dilution method. The antioxidant activity was evaluated by DPPH and FRAP methods, and the essential oil gave an IC 50 value of 0.451 mg/mL and a Trolox equivalent antioxidant concentration of 191.7 ± 11.3 μmol Trolox × g -1 in DPPH and FRAP, respectively. The results indicated that the essential oil was relatively active and may be useful in food and pharmaceuticals after more detailed study.

Aspterrics A and B, New Sesquiterpenes from Deep Sea-derived Fungus Aspergillus terreus YPGA10

“…The 13 C NMR spectrum, in combination with HSQC spectrum, resolved 15 carbon resonances attributable to three double bonds, three methyls, and six methylenes. The aforementioned data were similar to those of 1, indicating a farnesol derivative [12]. The structure was further established by detailed 2D NMR analyses (Figure 2).…”

Chemical Composition, Antimicrobial Properties of Siparuna guianensis Essential Oil and a Molecular Docking and Dynamics Molecular Study of its Major Chemical Constituent

“…The plants that produce essential oils (EOs) have been an object of study for years, since their EOs present varied biological activities [ 14 ], such as cytotoxic, antimicrobial, antioxidant [ 15 ], anti-inflammatory, anti-proliferative [ 16 , 17 , 18 ], antibacterial, antifungal [ 19 , 20 , 21 , 22 , 23 , 24 ], antiviral [ 25 , 26 ], anticonvulsant [ 27 , 28 ], analgesic [ 29 ], and neuroprotective properties [ 30 ]. As a result, they are increasingly attracting the attention of many industry segments [ 31 ].…”

Extract of Herba Anthrisci cerefolii: Chemical Profiling and Insights into Its Anti-Glioblastoma and Antimicrobial Mechanism of Actions

“…Aqueous extract of A. sylvestris leaves showed no cytotoxicity towards RAW264.7 macrophages cells, but induced an anti-inflammatory defense response in this cell model [ 35 ]. Essential oil of the aerial parts of A. caucalis showed cytotoxic activity on liver hepatocellular carcinoma (HepG2) and human breast adenocarcinoma (MCF-7) cells [ 36 ]. Our results on A. cerefolium are supporting previous data regarding cytotoxicity against cancer cell lines of the species of the genus.…”

“…Previous investigations were focused on essential oils from the genus Anthriscus and there are no reports about antimicrobial activity of methanolic extract of A. cerefolium . Namely, the essential oil from the aerial parts of Anthriscus caucalis M. Bieb showed significant activity against Bacillus subtilis and Escherichia coli with MIC values of 0.095 mg/mL and 0.105 mg/mL, respectively [ 36 ]. The essential oil obtained from the root of Anthriscus nemorosa (Bieb.)…”