Aspterrics A and B, New Sesquiterpenes from Deep Sea-derived Fungus Aspergillus terreus YPGA10

Li, Yuanli; Wan, Lei; Xu, Wei; Zeng, Xi; Cheng, Zhongbin; Li, Qin

doi:10.25135/rnp.131.19.04.1247

Cited by 12 publications

(10 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An investigation of the extracts from the deep-sea-sediment fungus Aspergillus terreus YPGA10, collected in the Yap Trench at a depth of 4159 m, furnished two new farnesol derivatives, sesquiterpenes aspterric A (14) and aspterric B (15), which are considered to be intermediates in the derivation of aspterric acid [17].…”

Section: Sesquiterpenesmentioning

confidence: 99%

A Review of Terpenes from Marine-Derived Fungi: 2015–2019

Jiang

Guo

et al. 2020

Marine Drugs

View full text Add to dashboard Cite

Marine-derived fungi are a significant source of pharmacologically active metabolites with interesting structural properties, especially terpenoids with biological and chemical diversity. In the past five years, there has been a tremendous increase in the rate of new terpenoids from marine-derived fungi being discovered. In this updated review, we examine the chemical structures and bioactive properties of new terpenes from marine-derived fungi, and the biodiversity of these fungi from 2015 to 2019. A total of 140 research papers describing 471 new terpenoids of six groups (monoterpenes, sesquiterpenes, diterpenes, sesterterpenes, triterpenes, and meroterpenes) from 133 marine fungal strains belonging to 34 genera were included. Among them, sesquiterpenes, meroterpenes, and diterpenes comprise the largest proportions of terpenes, and the fungi genera of Penicillium, Aspergillus, and Trichoderma are the dominant producers of terpenoids. The majority of the marine-derived fungi are isolated from live marine matter: marine animals and aquatic plants (including mangrove plants and algae). Moreover, many terpenoids display various bioactivities, including cytotoxicity, antibacterial activity, lethal toxicity, anti-inflammatory activity, enzyme inhibitor activity, etc. In our opinion, the chemical diversity and biological activities of these novel terpenoids will provide medical and chemical researchers with a plenty variety of promising lead compounds for the development of marine drugs.

show abstract

Section: Sesquiterpenesmentioning

confidence: 99%

A Review of Terpenes from Marine-Derived Fungi: 2015–2019

Jiang

Guo

et al. 2020

Marine Drugs

View full text Add to dashboard Cite

show abstract

“…In our continuous efforts to characterize bioactive natural products from deep-sea-derived Aspergillus strains [1,2], chemical examination of the fermentation broth of a deep-sea derived fungus Aspergillus sp. YPGA8 led to the isolation of two new compounds 12 (Figure 1).…”

Section: Plant Sourcementioning

confidence: 99%

Two New Compounds from the Deep-Sea-Serived Fungus Aspergillus sp. YPGA8

Pan¹,

Zhi-yong²,

Yang³

et al. 2020

Rec.Nat.Prod.

Self Cite

View full text Add to dashboard Cite

Chemical examination of a fraction of the EtOAc extract of a marine-derived fungus Aspergillus sp. YPGA8 resulted in the isolation of two new compounds, namely aspertriols AB (12). Compounds 12 possess an identical 2,3,4-trihydroxybutoxy moiety, which is rarely found in natural products. Their structures were determined by extensive analyses of spectroscopic data (1D and 2D NMR, HRESIMS). The bioassay study revealed that compounds 1 and 2 were inactive toward -glucosidase.

show abstract

“…In our efforts to search for bioactive molecules from deep-sea fungus [10][11][12][13][14], the fungal strain Penicillium thomii YPGA3 isolated from the sediments at a depth of 4500 m in the Yap Trench was screened out for chemical investigation, and the 1 H NMR spectrum and HPLC-DAD fingerprint of the EtOAc extract of this strain presented information that suggested the presence of chromone derivatives. As a result, eight new chromone derivatives, namely penithochromones M−T (1-8), along with two known analogues, 9 and 10, were obtained by 1 H NMR-guided isolation (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Chromone Derivatives with α-Glucosidase Inhibitory Activity from the Marine Fungus Penicillium thomii Maire

et al. 2021

Self Cite

View full text Add to dashboard Cite

The fungal strain YPGA3 was isolated from the sediments of the Yap Trench and identified as Penicillium thomii. Eight new chromone derivatives, named penithochromones M−T (1–8), along with two known analogues, 9 and 10, were isolated from the strain. The structures were established by detailed analyses of the spectroscopic data. The absolute configuration of the only chiral center in compound 1 was tentatively determined by comparing the experimental and the calculated specific rotations. Compounds 7 and 8 represent the first examples of chromone derivatives featuring a 5,7-dioxygenated chromone moiety with a 9-carbon side chain. Bioassay study revealed that compounds 6–10 exhibited remarkable inhibition against α-glucosidase with IC50 values ranging from 268 to 1017 μM, which are more active than the positive control acarbose (1.3 mmol).

show abstract

Aspterrics A and B, New Sesquiterpenes from Deep Sea-derived Fungus Aspergillus terreus YPGA10

Cited by 12 publications

References 12 publications

A Review of Terpenes from Marine-Derived Fungi: 2015–2019

A Review of Terpenes from Marine-Derived Fungi: 2015–2019

Two New Compounds from the Deep-Sea-Serived Fungus Aspergillus sp. YPGA8

Chromone Derivatives with α-Glucosidase Inhibitory Activity from the Marine Fungus Penicillium thomii Maire

Contact Info

Product

Resources

About