Two New Compounds from the Deep-Sea-Serived Fungus Aspergillus sp. YPGA8

Abstract

Chemical examination of a fraction of the EtOAc extract of a marine-derived fungus Aspergillus sp. YPGA8 resulted in the isolation of two new compounds, namely aspertriols AB (12). Compounds 12 possess an identical 2,3,4-trihydroxybutoxy moiety, which is rarely found in natural products. Their structures were determined by extensive analyses of spectroscopic data (1D and 2D NMR, HRESIMS). The bioassay study revealed that compounds 1 and 2 were inactive toward -glucosidase.

Marine natural products

“…Further Aspergillus strains yielded meroterpenoids 397–399 , 169 xanthenone 400 , 170 aromatic ether 401 , 171 polyketides 402–405 , 172 nucleoside derivatives 406 and 407 and bisabolane sesquiterpenoid 408 , 173 xanthone derivatives 409–411 , 174 412–417 , 175 triols 418 and 419 (ref. 176) and ophiobolins 420–424 . 177 Of these, determination of the absolute configuration of 397 was claimed through matching of the ECD curve of the natural compound with the calculated one but the match was extremely poor.…”