Marine natural products

Carroll, Anthony Richard; Copp, Brent R.; Davis, Rohan A.; Keyzers, Robert A.; Prinsep, Michèle R.

doi:10.1039/d1np00076d

Cited by 156 publications

(121 citation statements)

References 758 publications

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“…The sea environment possesses extraordinary ecological variety, and its inhabitants exhibit enormous biochemical diversity. At present, over 29,000 marine natural products have been discovered [ 1 , 2 , 3 , 4 ]. To date, several dozen marine natural products or their derivatives have been approved as therapeutic agents or are undergoing Phase III, II, or I drug development [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Although Porifera and Cnidaria are the two major sources of new marine natural products, Echinodermata is viewed as another abundant source of new bioactive compounds. Over the past five years, just over two hundred new compounds have been isolated from echinoderms [ 1 , 2 , 3 , 4 , 6 ]. The phylum Echinodermata includes about 7500 species found in all seas at every depth, from intertidal to abyssal, and in all ecosystems, from coral reefs to shallow shores.…”

Section: Introductionmentioning

confidence: 99%

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Application of MS-Based Metabolomic Approaches in Analysis of Starfish and Sea Cucumber Bioactive Compounds

2022

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Today, marine natural products are considered one of the main sources of compounds for drug development. Starfish and sea cucumbers are potential sources of natural products of pharmaceutical interest. Among their metabolites, polar steroids, triterpene glycosides, and polar lipids have attracted a great deal of attention; however, studying these compounds by conventional methods is challenging. The application of modern MS-based approaches can help to obtain valuable information about such compounds. This review provides an up-to-date overview of MS-based applications for starfish and sea cucumber bioactive compounds analysis. While describing most characteristic features of MS-based approaches in the context of starfish and sea cucumber metabolites, including sample preparation and MS analysis steps, the present paper mainly focuses on the application of MS-based metabolic profiling of polar steroid compounds, triterpene glycosides, and lipids. The application of MS in metabolomics studies is also outlined.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Application of MS-Based Metabolomic Approaches in Analysis of Starfish and Sea Cucumber Bioactive Compounds

2022

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“…Other non-vertebrates (and their symbionts) have also shown tremendous importance and relevance with respect to socio-economic impact. Snails, sponges and corals all produce metabolites with biological activities such as anticancer, anti-inflammatory, antibacterial, among others [14,15,16]. Terpenoid metabolites have been found in more than 70 gastropod species [17].…”

Section: Introductionmentioning

confidence: 99%

A Deep Dive into Genome Assemblies of Non-vertebrate Animals

Guiglielmoni¹,

Rivera‐Vicéns²,

Koszul³

et al. 2022

Preprint

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Non-vertebrate species represent about ~95% of known metazoan (animal) diversity. They remain to this day relatively unexplored genetically, but understanding their genome structure and function is pivotal for expanding our current knowledge of evolution, ecology and biodiversity. Following the continuous improvements and decreasing costs of sequencing technologies, many genome assembly tools have been released, leading to a significant amount of genome projects being completed in recent years. In this review, we examine the current state of genome projects of non-vertebrate animal species. We present an overview of available sequencing technologies, assembly approaches, as well as pre and post-processing steps, genome assembly evaluation methods, and their application to non-vertebrate animal genomes.

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“…Alga-associated microorganisms have attracted considerable attention and are proven to be a vital source for new compounds with interesting biological activities [ 9 ]. The genus Aspergillus , one of the main genera of marine-derived fungi, is rich in species [ 10 , 11 ], and marine-derived Aspergillus spp. produce structurally diverse secondary metabolites, including fatty acids, polyketides, alkaloids, and others, with a range of bioactivities [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Polyketides from an Alga-Derived Fungus Aspergillus ochraceopetaliformis SCSIO 41020

et al. 2022

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A new linear polyketide, named aspormisin A (1), together with five known polyketides (2−6), were isolated from the alga-derived fungus Aspergillus ochraceopetaliformis SCSIO 41020. Their structures were elucidated through a detailed comprehensive spectroscopic analysis, as well as a comparison with the literature. An anti-inflammatory evaluation showed that compounds 2, 5, and 6 possessed inhibitory activity against the excessive production of nitric oxide (NO) and pro-inflammatory cytokines in LPS-treated RAW 264.7 macrophages in a dose-dependent manner without cytotoxicity. Further studies revealed that compound 2 was active in blocking the release of pro-inflammatory cytokines (IL-6, MCP-1, and TNF-α) induced by LPS both in vivo and in vitro. Our findings provide a basis for the further development of linear polyketides as promising anti-inflammatory agents.

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Marine natural products

Abstract: A comprehensive review of 1407 new MNPs including turbinmicin, a potent antifungal lead isolated from a marine bacterium.

Cited by 156 publications

References 758 publications

Application of MS-Based Metabolomic Approaches in Analysis of Starfish and Sea Cucumber Bioactive Compounds

Application of MS-Based Metabolomic Approaches in Analysis of Starfish and Sea Cucumber Bioactive Compounds

A Deep Dive into Genome Assemblies of Non-vertebrate Animals

Anti-Inflammatory Polyketides from an Alga-Derived Fungus Aspergillus ochraceopetaliformis SCSIO 41020

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