Chemical composition, antimicrobial, insecticidal, phytotoxic and antioxidant activities of Mediterranean Pinus brutia and Pinus pinea resin essential oils

Ulukanlı, Zeynep; Karabörklü, Salih; Bozok, Fuat; Ateş, Burhan; Erdoğan, Selım; Çenet, Menderes; Karaaslan, Merve Gökşin

doi:10.1016/s1875-5364(14)60133-3

Cited by 52 publications

(37 citation statements)

References 33 publications

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“…(−)-β-caryophyllene (BCP), a functional non-psychoactive CB2 receptor agonist [12,13,14], is found in, for example, plant-derived oleoresins, essential oils, solutes, distillates, extracts, fermentations, infusions, and leachates, from several plants [15,16,17,18,19,20,21,22,23,24,25]. Furthermore, BCP showed analgesic, anti-inflammatory, neuroprotective, anti-depressive, anxiolytic, and anti-nephrotoxicity effects [12,13,26,27,28,29,30,31].…”

Section: Introductionmentioning

confidence: 99%

(−)-β-Caryophyllene, a CB2 Receptor-Selective Phytocannabinoid, Suppresses Motor Paralysis and Neuroinflammation in a Murine Model of Multiple Sclerosis

Alberti

Barbosa

Vieira

et al. 2017

IJMS

111

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(−)-β-caryophyllene (BCP), a cannabinoid receptor type 2 (CB2)-selective phytocannabinoid, has already been shown in precedent literature to exhibit both anti-inflammatory and analgesic effects in mouse models of inflammatory and neuropathic pain. Herein, we endeavored to investigate the therapeutic potential of BCP on experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS). Furthermore, we sought to demonstrate some of the mechanisms that underlie the modulation BCP exerts on autoimmune activated T cells, the pro-inflammatory scenery of the central nervous system (CNS), and demyelination. Our findings demonstrate that BCP significantly ameliorates both the clinical and pathological parameters of EAE. In addition, data hereby presented indicates that mechanisms underlying BCP immunomodulatory effect seems to be linked to its ability to inhibit microglial cells, CD4+ and CD8+ T lymphocytes, as well as protein expression of pro-inflammatory cytokines. Furthermore, it diminished axonal demyelination and modulated Th1/Treg immune balance through the activation of CB2 receptor. Altogether, our study represents significant implications for clinical research and strongly supports the effectiveness of BCP as a novel molecule to target in the development of effective therapeutic agents for MS.

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Section: Introductionmentioning

confidence: 99%

(−)-β-Caryophyllene, a CB2 Receptor-Selective Phytocannabinoid, Suppresses Motor Paralysis and Neuroinflammation in a Murine Model of Multiple Sclerosis

Alberti

Barbosa

Vieira

et al. 2017

IJMS

111

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“…are therapeutically used externally or by inhalation to treat different medical conditions, including respiratory disease, common colds, and rheumatic complaints such as muscle and joint pain [1–3]. Antioxidative, free radical scavenging, insecticidal, phytotoxic, larvicidal, repellent, anti-inflammatory, antiviral, and antifungal properties of Pinus essential oils have been reported as well [4–12]. Pine oil has also been used as a component of aromatherapy recipes [13].…”

Section: Introductionmentioning

confidence: 99%

Essential Oil Composition ofPinus peuceGriseb. Needles and Twigs from Two National Parks of Kosovo

Hajdari¹,

Mustafa²,

Nebija

et al. 2016

The Scientific World Journal

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The principal aim of this study was to analyze the chemical composition and qualitative and quantitative variability of essential oils obtained from seven naturally grown populations of the Pinus peuce Grisebach, Pinaceae in Kosovo. Plant materials were collected from three populations in the Sharri National Park and from four other populations in the Bjeshkët e Nemuna National Park, in Kosovo. Essential oils were obtained by steam distillation and analyzed by GC-FID (Gas Chromatography-Flame Ionization Detection) and GC-MS (Gas Chromatography-Mass Spectrometry). The results showed that the yield of essential oils (v/w dry weight) varied depending on the origin of population and the plant organs and ranged from 0.7 to 3.3%. In total, 51 compounds were identified. The main compounds were α-pinene (needles: 21.6–34.9%; twigs: 11.0–24%), β-phellandrene (needles: 4.1–27.7; twigs: 29.0–49.8%), and β-pinene (needles: 10.0–16.1; twigs: 6.9–20.7%). HCA (Hierarchical Cluster Analysis) and PCA (Principal Component Analyses) were used to assess geographical variations in essential oil composition. Statistical analysis showed that the analyzed populations are grouped in three main clusters which seem to reflect microclimatic conditions on the chemical composition of the essential oils.

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“…The antimicrobial activity of both these fractions was indicated in numerous studies e.g. Ulukanli et al [34] describes chemical compositions and antimicrobial activity of the essential oils belonging to Pinus pinea and Pinus brutia (main components-α-pinene, β-pinene and d-Limonene 1,4-methenoazulene and caryophyllene). Tiitta et al [35] revealed that there is a significant relation between the volatile organic compounds (mainly terpenes) and the mould resistance.…”

Section: Growth Of the A Niger Mycelium Depending On The Compositionmentioning

confidence: 99%

Resistance of Conifer Needle Polyolefin Composites (CNPCs) Against Biodecomposition Caused by Fungi

2017

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Chemical composition, antimicrobial, insecticidal, phytotoxic and antioxidant activities of Mediterranean Pinus brutia and Pinus pinea resin essential oils

Cited by 52 publications

References 33 publications

(−)-β-Caryophyllene, a CB2 Receptor-Selective Phytocannabinoid, Suppresses Motor Paralysis and Neuroinflammation in a Murine Model of Multiple Sclerosis

(−)-β-Caryophyllene, a CB2 Receptor-Selective Phytocannabinoid, Suppresses Motor Paralysis and Neuroinflammation in a Murine Model of Multiple Sclerosis

Essential Oil Composition ofPinus peuceGriseb. Needles and Twigs from Two National Parks of Kosovo

Resistance of Conifer Needle Polyolefin Composites (CNPCs) Against Biodecomposition Caused by Fungi

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