Chemical Composition, Antifungal and Antioxidant Activities of Hedyosmum brasiliense Mart. ex Miq. (Chloranthaceae) Essential Oils

Abstract

Background: Hedyosmum brasiliense Mart. ex Miq. (Chloranthaceae) is a dioecious shrub popularly used in Brazil to treat foot fungi and rheumatism. This work investigated the chemical composition, antifungal, and antioxidant activities of flowers and leaves of H. brasiliense essential oils; Methods: H. brasiliense male and female flowers and leaves were collected at Ilha do Cardoso (São Paulo) and the essential oils were extracted by hydrodistillation and analyzed by GC/MS and their similarity compared by Principal Component Analysis. Antifungal activity was performed by bioautography and antioxidant potential by 2,2-diphenyl-2-picrylhydrazyl hydrate (DPPH) free radical scavenging and β-carotene/linoleic acid system; Results: The major compounds for all oils were sabinene, curzerene, and carotol, but some differences in their chemical composition were discriminated by Principal Component Analysis (PCA) analysis. Bioautography showed two antifungal bands at Rf’s 0.67 and 0.12 in all samples, the first one was identified as curzerene. The oils presented stronger antioxidant potential in β-carotene/linoleic acid bioassay, with IC50’s from 80 to 180 μg/mL, than in DPPH assay, with IC50’s from 2516.18 to 3783.49 μg/mL; Conclusions: These results suggested that curzerene might be responsible for the antifungal activity of H. brasiliense essential oils. Besides, these essential oils exhibited potential to prevent lipoperoxidation, but they have a weak radical scavenger activity.

Composición química del aceite esencial de las hojas de Hedyosmum luteynii Todzia (Chloranthaceae)

“…La prevalencia de monoterpenos en el aceite esencial de H. luteynii es comparable a lo reportado para otras de las especies Hedyosmum. También, se han encontrado prevalencia de los monoterpenos en H. mexicanum (Mundina et al 2000), H. bonplandianum (Mundina et al 2000), H. arborescens (Sylvestre et al 2007), H. brasilense (Kirchner et al, 2010;Murakami et al, 2017), colombianum (Delgado et al 2010), H. angustifolium (Lorenzo et al 2003), y H. scambrum (Lorenzo et al, 2003; Morocho Zaragocín, 2015) (Tabla 2).…”

“…Ex Mid. -Brasil- (Murakami et al 2017); H. brasiliense Miq. -Brasil- (Kirchner et al 2010); H. glabratum Kunh -Venezuela- (Danis et al 2012); H. colombianum Cuatrec -Colombia- (Delgado et al 2010); H. translucidum Cuatrec -Colombia-(Zamora-Burbano & Arturo-Perdomo 2016); H. angustifolium (R et P.) Solms-Laubach -Bolivia-y H. scambrum (R et P.) Solms-Laubach -Bolivia- (Lorenzo et al 2003); H. sprucei Solms.…”

Variability of the Chemical Composition and Bioactivity between the Essential Oils Isolated from Male and Female Specimens of Hedyosmum racemosum (Ruiz & Pav.) G. Don

“…The antioxidant results for DPPH and ABTS assays indicate a weak scavenging capacity; at the concentrations evaluated, only the female EO of H. racemosum allows to calculate the SC 50 at a value of 800 μg/mL for ABTS assay. Murakami et al in 2017 reported the antioxidant activity for male EO and female EO species of H. brasiliense for flowers with an SC 50 of 2516.18 μg/mL and 3162.79 μg/mL, respectively; meanwhile, for leaves, they found an SC 50 of 3783.49 μg/mL and 3542.01 μg/mL, respectively [ 10 ]. Anthony et al [ 18 ] analyzed the antioxidant activity of pure essential oil components and concluded that hydrocarbons present very low antioxidant activity, but phenol compounds are more active followed by mono- and sesquiterpenes; from these data, it can be assumed that the antioxidant activity of EO depends on the abundance of more active compounds and explains the lower or no antioxidant activity for some EO.…”

“…The genus Hedyosmum is also an important source of essential oils (EOs) that can be extracted from different parts of plants, such as aerial parts, leaves, flowers, and fruits. The chemical composition and the potential for different applications of these EOs have been described in numerous studies [ 6 , 7 , 10 ].…”

Editan ( Lasianthera africana ) leaf‐inclusive diets modulate some neuronal enzyme activities and antioxidant status of cyclophosphamide‐treated Wistar rats

“…However, pre‐treatment with DON and ELD modulated the enzyme activity (Figure 7). This effect could be due to the individual constituent phytochemicals and/or their synergistic effects as plant‐derived alkaloid as well as polyphenols have been reported to possess antitumor, anti‐inflammatory, anti‐cholinergic, and antioxidant effects (Murakami, Cordeiro, Scotti, Moreno, & Young, 2017; Naaz, Singh, Pandey, Singh, & Dwivedi, 2013).…”