Editan (
            <i>Lasianthera africana</i>
            ) leaf‐inclusive diets modulate some neuronal enzyme activities and antioxidant status of cyclophosphamide‐treated Wistar rats

Nwanna, Esther E.; Oyeleye, Sunday I.; Oboh, Ganiyu

doi:10.1111/jfbc.13427

Cited by 4 publications

(2 citation statements)

References 40 publications

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“…The incidence of Alzheimer's disease (AD) involves the continuous loss of neurons, cognition, and memory deficit, and difficulty in recognizing (Etindele‐Sosso, 2017). AD is a pathology arises from several conditions, including oxidative stress, a deficit of acetylcholine (ACh) neurotransmitter in the synaptic cleft, β‐amyloid deposition, and tau protein phosphorylation (Castellani et al., 2001; Nwanna et al., 2020). Inhibitors of cholinesterases (ChEs) [acetylcholinesterase (AChE) and butyrylthiocholinesterase (BChE)] activities are known for their effectiveness in the management of AD (Arnold & Kumar, 1993; Oboh et al., 2020).…”

Section: Introductionmentioning

confidence: 99%

Citrus spp . essential oils improve behavioral pattern, repressed cholinesterases and monoamine oxidase activities, and production of reactive species in fruit fly ( Drosophila melanogaster ) model of Alzheimer’s Disease

et al. 2020

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Much emphasis has been placed on the biological activities of citrus peel's essential oils (CPEOs) against human ailments. This study investigated the effect of Citrus limon and Citrus reticulata peel's essential oils (EOs) on behavioral and neurochemical imbalance in transgenic and Harwish (Wild) fruit flies. Flies were divided into seven groups comprising of the control and those that were fed with 0.1, 0.5, and 1.0 µg/ ml of the dietary inclusions of study CPEOs for 7 days. Thereafter, behavioral profile was examined using lethality response and negative geotaxis assays. Effect of the EOs on cholinesterase and monoamine oxidase (MAO) activities, and antioxidative parameters were determined. The result showed a significant improvement of behavioral pattern and biochemical parameters of the flies fed with studied CPEOs inclusive diets. Conclusively, both EOs exert neuroprotective capability by reducing cholinesterases and monoamine activities, and also prevent oxidative stress, which are implicated in neuronal dysfunction in humans. Practical applications With the growing increase in the search for safer alternatives, having no side effects, for the management of neurodegenerative diseases, a large proportion of the populace is beginning to find solace in the use of natural products. Also, the wide array of similarities between the humans and the dipteran insects, fruit flies is a perfect organism for the study of neurodegenerative diseases. Therefore, this study presents the neuroprotective potentials of lemon and tangerine peels-derived EOs, and the possibility of their exploration as neuroactive agents and alternative in the management of Alzheimer's disease (AD).

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Section: Introductionmentioning

confidence: 99%

Citrus spp . essential oils improve behavioral pattern, repressed cholinesterases and monoamine oxidase activities, and production of reactive species in fruit fly ( Drosophila melanogaster ) model of Alzheimer’s Disease

et al. 2020

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“…At the same time, it can also damage normal cells ( 53 ). It not only causes immune suppression but also affects the antioxidant capacity of the body to varying degrees ( 54 , 55 ). Under normal conditions, reactive oxygen species (ROS) in organisms are controlled at a low range to form homeostasis, yet the stimulation of CTX can cause the imbalance of ROS in vivo .…”

Section: Discussionmentioning

confidence: 99%

The Protective Effects of Three Polysaccharides From Abrus cantoniensis Against Cyclophosphamide-Induced Immunosuppression and Oxidative Damage

Lian

et al. 2022

Front. Vet. Sci.

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This study was designed to systematically elucidate the immunomodulatory and antioxidant effects of three polysaccharide fractions (ACP60, ACP80, and ACPt2) from Abrus cantoniensis on cyclophosphamide (CTX)-induced immunosuppressive mice. The experimental mice were divided into 12 groups, then modeled and administrated with different doses of three polysaccharides (50, 150, 300 mg/kg/day) by gavage. The results showed that ACP could markedly recover the CTX-induced decline in immune organ and hemocytes indexes and promote proliferation of splenocytes, earlap swelling rate, secretion of cytokines (TNF-α, IFN-γ, IL-1β, IL-6), and immunoglobulin (Ig-M and Ig-G). Additionally, ACP improved the enzymatic activities of T-SOD and GSH-PX greatly, while the level of MDA was significantly decreased in the liver. In particular, ACPt2 had higher immunomodulatory and antioxidant activities than ACP60 and ACP80. Based on the present findings, ACP could be utilized as an efficacious candidate for immunomodulators and antioxidants, which provide a new application prospect in the food and pharmaceutical industries.

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Phytochemical profiling and neuroprotective activity of Callistemon subulatus leaves against cyclophosphamide-induced chemobrain

Rabie,

El-Nashar,

George

et al. 2023

Biomedicine & Pharmacotherapy

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Editan ( Lasianthera africana ) leaf‐inclusive diets modulate some neuronal enzyme activities and antioxidant status of cyclophosphamide‐treated Wistar rats

Cited by 4 publications

References 40 publications

Citrus spp . essential oils improve behavioral pattern, repressed cholinesterases and monoamine oxidase activities, and production of reactive species in fruit fly ( Drosophila melanogaster ) model of Alzheimer’s Disease

Citrus spp . essential oils improve behavioral pattern, repressed cholinesterases and monoamine oxidase activities, and production of reactive species in fruit fly ( Drosophila melanogaster ) model of Alzheimer’s Disease

The Protective Effects of Three Polysaccharides From Abrus cantoniensis Against Cyclophosphamide-Induced Immunosuppression and Oxidative Damage

Phytochemical profiling and neuroprotective activity of Callistemon subulatus leaves against cyclophosphamide-induced chemobrain

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