Chemical Composition and the Potential of Lavandula angustifolia L. Oil as a Skin Depigmentant

Abstract

Finding non-invasive skin depigmenting agentsrepresent an important goal of cosmetic research and industry. It is now admited that Tyrosinase inhibitor substances could be the most efficient molecules in this field because Tyrosinase is the key enzyme in the melanogenesis process. In the pathology of macular skin hyperpigmentations it can mention aesthetic problems such as: melasma gravidarum, pigmentation of aged skin, photosensibilisation, hepatic disfunctions and post-inflammatory residual pigmentation. The aim of the study was to find out if the Lavandula essential oil has depigmenting properties on human skin, having as theoretical premise its tyrosinase-blocking effect, previously reported in literature for some plant species. By using gas chromatograph coupled with mass spectrometer (GC/MS), a pharmaceutical cream preparation, a protocol of exploration on volunteers (including criteria) and a mexameter, we have highlighted the composition of a sample of Lavandula angustifolia essential oil (LEO) and its depigmenting effect on skin melanic macula. The results highlightes that the main compounds identified were linalool (26.783%), terpinen-4-ol (22.143%) and 3-carene(21.668%), Terpinen-4-ol is represented as the possible active compound in tyrosinase inhibition. Our dermocosmetic assay shows that the depigmenting effect of Lavandula angustifolia oil is effective after 2 months of daily topical treatement, when the melanine average value (measured by the mexameter) decreases more than a third from the innitial value. The study remarks that Lavandula angustifolia essential oil (LEO) in daily cutaneous pharmaceutical form application, during two month, reduces the intensity of spot skin melanin, exprimed through mexametric values.Keywords: Lavandula angustifolia L.; tyrosinase inhibitor; melanic skin macula.

Composition, and antioxidant and enzyme‐inhibition activities, of essential oils from Satureja thymbra and Thymbra spicata var. spicata

“…Anti‐tyrosinase activities have also been reported for the essential oils from Origanum vulgare, Chenopodium botrys , the fresh and dry fruits of Myoporum insulare , Lavandula angustifolia , the aerial parts of Beta vulgaris , Ocimum basilicum , and Piper magnibaccum …”

“…An increased level of melatonin in the skin can lead to skin pigmentation disorders, such as age spots or melasma. 41,42 Anti-tyrosinase activities have also been reported for the essential oils from Origanum vulgare, 13 Chenopodium botrys, 39 the fresh and dry fruits of Myoporum insulare, 43 Lavandula angustifolia, 44 the aerial parts of Beta vulgaris, 45 Ocimum basilicum, 46 and Piper magnibaccum. 47 The inhibition of α-amylase and α-glucosidase can be used to manage blood glucose and to protect against diabetes mellitus, which is a major public health problem in every part of the world.…”

Study on the Stability and Compatibility of the Cosmetic Products with Lavandula angustifolia Oil Kept in PPH Polypropylene Homopolymer Plastic Containers

“…The products used in cosmetic formulations are constantly diversifying as a result of researches in the field, which combine the healing and prevention of many skin conditions with the use of natural products such as vegetable extracts and essential oils [9,18,19]. Research and innovation in this field, as well as in pharmaceutical and environmental fields [20,21] have become necessary, especially nowadays when physical, chemical, and environmental aggressions on the skin cause increasing incidence of skin cancers [22,23].…”

Periorbital Hyperpigmentation, a Dermatologic Condition Having a Strong Geographic and Ethnic Determinism

“…[47] Although the list of natural tyrosinase-blocking depigmenting compounds is always open to researchers, their transposition into industrial practice appears late. [48] 6. Conclusions…”