Finding non-invasive skin depigmenting agentsrepresent an important goal of cosmetic research and industry. It is now admited that Tyrosinase inhibitor substances could be the most efficient molecules in this field because Tyrosinase is the key enzyme in the melanogenesis process. In the pathology of macular skin hyperpigmentations it can mention aesthetic problems such as: melasma gravidarum, pigmentation of aged skin, photosensibilisation, hepatic disfunctions and post-inflammatory residual pigmentation. The aim of the study was to find out if the Lavandula essential oil has depigmenting properties on human skin, having as theoretical premise its tyrosinase-blocking effect, previously reported in literature for some plant species. By using gas chromatograph coupled with mass spectrometer (GC/MS), a pharmaceutical cream preparation, a protocol of exploration on volunteers (including criteria) and a mexameter, we have highlighted the composition of a sample of Lavandula angustifolia essential oil (LEO) and its depigmenting effect on skin melanic macula. The results highlightes that the main compounds identified were linalool (26.783%), terpinen-4-ol (22.143%) and 3-carene(21.668%), Terpinen-4-ol is represented as the possible active compound in tyrosinase inhibition. Our dermocosmetic assay shows that the depigmenting effect of Lavandula angustifolia oil is effective after 2 months of daily topical treatement, when the melanine average value (measured by the mexameter) decreases more than a third from the innitial value. The study remarks that Lavandula angustifolia essential oil (LEO) in daily cutaneous pharmaceutical form application, during two month, reduces the intensity of spot skin melanin, exprimed through mexametric values.Keywords: Lavandula angustifolia L.; tyrosinase inhibitor; melanic skin macula.

Last decades often presented references to traditional medicine, or culinary use of natural resources for a better health status, prevention or treatment of different diseases. One of the natural plants came lately in the researches as a miracle salve: Nigella sativa. Also commonly known as black cumin, the most use of this plant are the seeds, such as, as powder, as oil extract, or as hydro or alcoholic extracts. Culinary usage of N. sativa is referring to the seeds used as spice. Medical usage of this plantis mostly used as oil or extracts administrated orally or intraperitoneal. The best demonstrated bioactive component is thymoquinone, an alkaloid, monotherpenoid compound, that seems to be the key of medical benefits of N. sativa. Experimental medicine proved that seeds of black cumin have health enhancement and pharmaceutical effects, being used in various disseases (cardiac, digestive and respiratory diseases; hepatic and renal tonic; inflammations; reproductive and neural disorders, analgesic; appetite stimulant; cancer prevention and treatment; spasmolytic and diabetes. Seeds (as powder, oil or hydro, alcoholic extracts) have been demonstrated that have antimicrobial, antiparasitic, antitumoral, antidiabetic, antioxidant, and anti-inflammatory action. N. sativa is easy to cultivate, storing, and offering diver potential of use as seed, seed oil, different type of seed extracts.