Chemical composition and in vitro antioxidative potential of essential oil isolated from Curcuma longa L. leaves

Priya, R.; Prathapan, A.; Raghu, K.; Menon, A. Nirmala

doi:10.1016/s2221-1691(12)60298-6

Cited by 45 publications

(30 citation statements)

References 8 publications

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“…For EOCL, the chemical composition found in this study agrees with the results reported by Priya et al . (), in which β‐sesquiphellandrene (22.8%) and terpinolene (9.5%) were the predominant constituents.…”

Section: Discussionmentioning

confidence: 99%

Anaesthetic and antioxidant effects ofMyrcia sylvatica(G. Mey.)DC. andCurcuma longaL. essential oils on tambaqui (Colossoma macropomum)

et al. 2016

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Anaesthetic substances are necessary to reduce fish stress during aquaculture activities. The objectives of this study were: (i) to determine the efficacy of essential oils (EOs) of Myrcia sylvatica (EOMS) and Curcuma longa (EOCL) as anaesthetics for Colossoma macropomum and (ii) to evaluate the effects of rapid anaesthesia and long-term sedation (6 h) with these oils. Therefore, the main primary stress indicator (cortisol) and secondary factors (biochemical indices, hepatic metabolism, oxidative biomarkers) were measured. Sedation with the EOCL resulted in lower cortisol levels compared to control group. Total cholesterol levels were lower in fish sedated with EOMS than in control. Lactate levels were higher in fish anaesthetized with both EOs and sedated with EOCL compared to control. Both EOs increased hepatic glycogen levels after anaesthesia and EOMS increased this parameter after sedation compared to control. Anaesthesia and sedation with EOs resulted in lower levels of lipid peroxidation (LPO) compared to control. In turn, the activity of some antioxidant enzymes evaluated (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione-S-transferase), the content of non-protein thiols and total reactive antioxidant potential were higher in tissues of fish anaesthetized and sedated with EOs compared to control. This induction of antioxidant capacity in the tissues could be due to the antioxidant property exerted by these EOs. Thus, EOMS and EOCL are recommended for anaesthesia and sedation of fish because in spite of inducing anaerobic metabolism, these EOs did not alter most biochemical parameters, reduced the LPO and increased the antioxidant capacity in vital tissues.

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Section: Discussionmentioning

confidence: 99%

Anaesthetic and antioxidant effects ofMyrcia sylvatica(G. Mey.)DC. andCurcuma longaL. essential oils on tambaqui (Colossoma macropomum)

et al. 2016

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“…However, curcumin inhibits androgen-dependent and androgen-independent PCa cell growth at concentrations of 40 µM to 100 µM [27]. While the diversity of compounds in turmeric is extensive [28,29], a less commonly studied one is arturmerone from the sesquiterpenes (ratio of curcumin to ar-turmerone in turmeric is approximately 4:1) [30,31], with reported IC 50 values in a variety of cancer cell lines of >243 µM [32][33][34][35][36]; however, ar-turmerone has not been studied in PCa. Similarly, the potential synergy between these compounds has yet to be tested.…”

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confidence: 99%

Turmeric and Chinese goldthread synergistically inhibit prostate cancer cell proliferation and NF-kB signaling

Zhao

Collier

Huang

et al. 2014

FFHD

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ABSTRACT:Background: Pre-clinical studies using bioactive compounds from botanicals appear to offer some protection against cancer. Research using single bioactives contributes greatly to our understanding of their mechanism of action, but in vitro studies demand concentrations that are higher than achievable in humans (µM). However, maintaining these bioactives in the presence of other compounds originally derived from the food or extract of origin may synergistically lower the bioactive dose so translatability becomes feasible. The objective of this study was to determine if bio-efficacy of phytonutrients can be enhanced when used in combination even at doses that are ineffective for any compound when used in isolation. Methods:The anti-proliferative and molecular effects of herbs (turmeric and Chinese goldthread) and their bioactives (curcumin and ar-turmerone, berberine and coptisine, respectively) were determined in isolation and in combination. Using CWR22Rv1 and HEK293 cells, cell proliferation (as assessed by the MTT assay) and NF-κB promoter activity (using a luciferase reporter construct) were evaluated and synergy of action was assessed by the ChouTalalay method utilizing CompuSyn ® software.Results: Turmeric and Chinese goldthread act synergistically (combination index<1) when inhibiting cell proliferation with all cell lines tested. The synergy of action of combinations of companion bioactives from the same herb (i.e., curcumin/ar-turmerone and berberine/coptisine) and bioactives from different herbs (i.e., curcumin/berberine) help to explain why turmeric and Chinese goldthread are more effective than their major bioactives in isolation. At the molecule level, curcumin+ar-turmerone and curcumin+coptisine synergistically attenuated TNFα-stimulated NF-κB promoter activity. Even compounds with poor efficacy become more biologically active in the presence of companion compounds. Importantly, the effects of combining any two bioactives or herbal extracts were highly synergistic at concentrations approaching physiological significance (nanomolar). Conclusions:These results suggest that bioactives in combination (as plant extracts or isolated compounds) are highly synergistic at the cellular and molecular level at physiologically relevant concentrations. These data help to explain why complex mixtures of botanicals may be more efficacious than their bioactives in isolation.

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“…Aluminum chloride spectrophotometric method was used for flavonoids determination described by previous studies [32]. Take 250 μl of extracts (1 mg/ml) were mixed with 1.25 ml of distilled water and 75 μl of 5% NaNO 2 solution.…”

Section: Determination Of Total Flavonoidsmentioning

confidence: 99%

Nutritional Evaluation of Curcuma Species Collected from Different Agro Climatic Regions of Chhattisgarh

Jain¹,

Dk²

2017

Am J Ethnomed

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In present study rhizomes of Curcuma longa, Curcuma caesia and Curcuma aromatica from different regions of Chhattisgarh choose for best chemo type identification based on their nutritional evaluation and proximate analysis. Curcuma samples collected from Sarguja district showed highest antioxidant potential in most of the in-vitro assay. All the values compared by standard curcumin and showed significant variation in region wise. It can be conclude from the result that irrespective of the origin or variety, Curcuma is a good natural reservoir of energy whose nutritive components can be used as a food supplement.

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Chemical composition and in vitro antioxidative potential of essential oil isolated from Curcuma longa L. leaves

Cited by 45 publications

References 8 publications

Anaesthetic and antioxidant effects ofMyrcia sylvatica(G. Mey.)DC. andCurcuma longaL. essential oils on tambaqui (Colossoma macropomum)

Anaesthetic and antioxidant effects ofMyrcia sylvatica(G. Mey.)DC. andCurcuma longaL. essential oils on tambaqui (Colossoma macropomum)

Turmeric and Chinese goldthread synergistically inhibit prostate cancer cell proliferation and NF-kB signaling

Nutritional Evaluation of Curcuma Species Collected from Different Agro Climatic Regions of Chhattisgarh

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