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Ventral pallidum DRD3 potentiates a pallidohabenular circuit driving accumbal dopamine release and cocaine seeking Highlights d DRD3-mediated plasticity in the VP drives post-abstinence cocaine-seeking behavior d VP DRD3 signaling regulates dopamine release in the NAc latSh during seeking d VP DRD3 + projections to the LHb and VTA display differing activity during seeking d DRD3 signaling/activity of LHb-projecting VP DRD3 + neurons drives seeking behavior

Textured Mg alloys exhibit tension – compression strength asymmetry due to mechanical twinning. The distinction arises as the material deforms primarily by slip in one direction and by twinning in the other. In-situ neutron diffraction during cyclic loading in tension and compression of extruded bar allows study of the effect of twinning on subsequent load reversals. The diffraction data reveal the texture evolution and internal stress development as a function of deformation. De-twinning resulted in complete texture reversal during initial cycles, but eventually “fatigued” resulting in some residual twin component.

Diaphragmatic injury is a rare entity and clinically difficult to be diagnosed as symptoms are often masked due to associated injury in a poly trauma case. There are no specific signs and symptoms for diagnosing diaphragmatic rupture. High degree of clinical suspicion is needed in all cases of thoraco-abdominal injury to diagnose a case of diaphragmatic rupture. Computed Tomography (CT) chest and abdomen is very useful in diagnosis. When in doubt a diagnostic laparoscopy should be undertaken to establish a diagnosis to reduce mortality and morbidity.