Chemical composition and cytotoxicity analysis of the essential oil from leaves of<i>Croton argyrophyllus</i>Kunth

Araújo, Silvan Silva de; Santos, Matheus Ismerim Silva; Dias, Antônio Santos; Ferro, Jaqueline dos Santos; Lima, Rafaely N.; Barreto, Emiliano; Corrêa, Cirino; Araujo, Brancilene Santos de; Lauton-Santos, Sandra; Shan, Andrea Yu Kwan Villar; Alves, Péricles Barreto; Santana, Antônio Euzébio Goulart; Thomazzi, Sara Maria; Antoniolli, Ângelo Roberto; Estevam, Charles S.

doi:10.1080/10412905.2014.956233

Cited by 9 publications

(18 citation statements)

References 26 publications

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“…The EO from C . argyrophyllus may exhibit seasonal and geographical variability, showing an intraspecific variability regarding the classes of terpenes . Furthermore, Morais et al .…”

Section: Discussionmentioning

confidence: 99%

Impact of Croton argyrophyllus essential oil on behavioural models of nociception

Ramos

Santos

Santana

et al. 2016

Flavour & Fragrance J

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Croton argyrophyllus Kunth (Euphorbiaceae) is a shrub abundant in the northeast region of Brazil where it possesses ethnobotanical use. To assess the antinociceptive action of C. argyrophyllus, studies were conducted in behavioural models of nociception, and some of the mechanisms given under this effect investigated. The essential oil (EO) of C. argyrophyllus leaves (10, 30 and 100 mg/kg) was used in mice via the oral route in both the chemicals (acetic acid, formalin, capsaicin and glutamate) and thermal nociception models. The EO produced inhibition of acetic acid‐induced visceral pain (10, 30 and 100 mg/kg, p.o.) and it produced a significant antinociception effect in the hot plate test (100 mg/kg). In the formalin test, the EO caused significant inhibition of both the early (100 mg/kg) and the late (30 and 100 mg/kg) phases of formalin‐induced licking. The EO (30 and 100 mg/kg) also caused significant inhibition of capsaicin‐ and glutamate‐induced pain. The EO (100 mg/kg) antinociception in the hot plate test was significantly attenuated by treatment with naloxone. In contrast, the EO (100 mg/kg) antinociception in the abdominal constriction test was not affected by treatment of mice with L‐arginine. The present results suggest that the EO from C. argyrophyllus produced antinociception in several models of pain in mechanisms that involved glutamatergic and opioid systems. Copyright © 2016 John Wiley & Sons, Ltd.

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“…The EO from C . argyrophyllus may exhibit seasonal and geographical variability, showing an intraspecific variability regarding the classes of terpenes . Furthermore, Morais et al .…”

Section: Discussionmentioning

confidence: 99%

Impact of Croton argyrophyllus essential oil on behavioural models of nociception

Ramos

Santos

Santana

et al. 2016

Flavour & Fragrance J

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“…The chemical composition of oils from C. argyrophyllus has been investigated and has been revealed that chemotypes containing main constituents like bicyclogermacrene, (E)-caryophyllene and spathulenol are among the most widely known. [9,[21][22][23][24] The composition of the chemotype that is presented in this paper, with bicyclogermacrene, (Z)-caryophyllene, germacrene B and epi-longipinanol as the main constituents, is different from those previously registered in the literature. This variation in the composition in relation to previous studies, may be due to several factors such as the specific location of where the plant was collected, vegetative cycle, botanical origin, climate factors.…”

Section: Composition Of the Essential Oilsmentioning

confidence: 98%

“…The main compound found in the population investigated was bicyclogermacrene in concentrations ranging from 21.4 % to 62.9 % (average: 38.4 %), which presented a very high amount in relation to the analysis of other oils of this species. [9,[21][22][23][24] It was followed by (Z)-caryophyllene, ranging from 5.4 % to 23.6 % (average: 14.1 %), which did not show significant concentrations in previous studies, [9,[21][22][23][24] which was followed by germacrene B, ranging from 2.3 % to 16.8 % (average: 9.1 %) and present in all samples, and then epi-longipinanol with a range from 5.1 % to 14.2 % (average: 9.78 %), present in eight samples and is being identified for the first time in C. argyrophyllus essential oil. Furthermore, common sesquiterpenes occurring in nearly all samples in low proportions were β-elemene, spathulenol and caryophyllene oxide.…”

Section: Composition Of the Essential Oilsmentioning

confidence: 99%

“…[20] The chemical composition and insecticidal, antimicrobial, antioxidant, cytotoxic, anti-inflammatory, antinociceptive and gastroprotective activities of C. argyrophyllus essential oil have been studied, mainly in the plants in northeastern Brazil. [21][22][23][24] However, these studies demonstrated great differences in the reported oil compositions, including the major identified compounds. Like in many other plant species, these chemical variations can be attributed to genetic and environmental factors, in addition to the conditions related to the extraction process or time of collection.…”

Section: Introductionmentioning

confidence: 99%

“…The chemical composition and insecticidal, antimicrobial, antioxidant, cytotoxic, anti‐inflammatory, antinociceptive and gastroprotective activities of C. argyrophyllus essential oil have been studied, mainly in the plants in northeastern Brazil [21–24] . However, these studies demonstrated great differences in the reported oil compositions, including the major identified compounds.…”

Section: Introductionmentioning

confidence: 99%

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Chemodiversity and Antibacterial Activity of the Essential Oil of Leaves of Croton argyrophyllus

Araújo

Véras

Alves

et al. 2020

Chemistry & Biodiversity

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The Croton argyrophyllus leaf essential oil has anti-inflammatory, antioxidant, cytotoxic among other activities. However, there are chemical composition variations in the literature. This work reports the first study of the intraspecific chemical variation of C. argyrophyllus population from Pernambuco state, Brazil. The essential oils of nine specimens (OCA1 to OCA9) were analyzed by GC/MS and NIR to identify the chemical compositions and to verify the similarities between the analyzed samples. These analyses resulted in the identification of bicyclogermacrene (mean 38.42 %), (Z)-caryophyllene (mean of 14.06 %), epi-longipinanol (mean of 9.78 %) and germacrene B (mean of 9.1 %) as the major constituents, as well as the same chemical markers for all oil samples. However, these are different to those that were previously registered in the literature for C. argyrophyllus essential oil. The data obtained from the analysis by NIR spectroscopy were treated by PCA and HCA and showed similarities in the chemical samples' profile. By statistical analyses three clusters were obtained: OCA1-6, OCA7-8 and OCA9. All these groups were potentially active against Staphylococcus aureus. However, the OCA7-8 group was the most active.

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Application crude multienzyme extract from Aspergillus niger as a pretreatment for the extraction of essential oil from Croton argyrophyllus leaves

Costa

Gualberto

Oliveira

et al. 2021

Biotech and App Biochem

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Leaves of Croton argyrophyllus contain essential oil with promising active components for the development of drugs and botanical insecticides. In this study, we evaluated the enzymatic pretreatment process to increase the extraction of essential oil from fresh and dried leaves of C. argyrophyllus. Pretreatment was carried out using a crude multienzymatic extract obtained via solid‐state fermentation of forage palm by Aspergillus niger, and the extraction was performed by hydrodistillation. A Doehlert matrix was used to optimize the enzymatic pretreatment variables temperature and enzymatic extract. The effect of pretreatment time was also investigated. At optimum experimental conditions, 41.34°C, 140 min, and 130.73 mL of enzyme in 369.27 mL of water, the essential oil yield from fresh leaves subjected to enzymatic pretreatment increased by 9.35% and that from dry leaves by 6.77%. Based on chromatographic analysis (GC–MS), no compound was degraded in the extraction process. Micromorphological analysis confirmed the rupture of the glandular trichomes, favoring essential oil release. Therefore, enzymatic pretreatment associated with hydrodistillation increased the essential oil yield and is a promising application to obtain essential oil for therapeutic purposes without altering its composition.

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Chemical composition and cytotoxicity analysis of the essential oil from leaves ofCroton argyrophyllusKunth

Cited by 9 publications

References 26 publications

Impact of Croton argyrophyllus essential oil on behavioural models of nociception

Impact of Croton argyrophyllus essential oil on behavioural models of nociception

Chemodiversity and Antibacterial Activity of the Essential Oil of Leaves of Croton argyrophyllus

Application crude multienzyme extract from Aspergillus niger as a pretreatment for the extraction of essential oil from Croton argyrophyllus leaves

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