Chemical Composition and Biological Activities of the <i>Cladanthus mixtus</i> Essential Oil: A Review

Elouaddari, Anass; Cayuela, José Antonio; Bellahcen, Touria Ould; Zouiten, A.; Eddine, Jamal Jamal

doi:10.1080/22297928.2019.1682665

Cited by 6 publications

(5 citation statements)

References 34 publications

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“…The composition of C. scariosus essential oil differed drastically from those reported for the common Moroccan C. mixtus (Synonyms: Anthemis mixta , Chamaemelum mixtum , Ormenis mixta ) essential oils that displayed a fair chemical variability. Indeed, most compositions, recently reviewed [28] were dominated by a major component: santolina alcohol (24.1–55.1 %); [29,30] (E)‐β‐farnesene (35.5–50.5 %); [31,32] 2‐methyl‐2‐E‐butenyl methacrylate (32.0–35.2 %); [31–33] camphor (21.4 %); [31,34] α‐thujone (51.8 %) [35] . The composition of C. scariosus essential oil varied also from that of the essential oil from C. eriolepis , endemic to Morocco, dominated either by camphor (37.0 %); [36] α‐pinene (13.0 %), isobutyl angelate (10.7 %), 2‐methybutyl angelate (9.5 %); [37] iso‐butyl isobutyrate (21.2/20.8 %), iso‐butyl angelate (22.0/22.4 %) [16] …”

Section: Resultsmentioning

confidence: 99%

Composition and Chemical Variability of the Essential Oil from Aerial Parts of Cladanthus scariosus, an Endemic Species to the Moroccan High Atlas

Tomi

Hafidi

Bakhy

et al. 2022

Chemistry & Biodiversity

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Cladanthus scariosus (Ball) Oberpr. & Vogt is endemic to Moroccan High Atlas. It is known under the vernacular names Irezghi or Irezgui. Three essential oil samples have been isolated from aerial parts and analyzed by combination of chromatographic and spectroscopic techniques [gas chromatography (GC) in combination with retention indices (RI), gas chromatography-mass spectrometry (GC/MS) and 13 C-NMR spectroscopy]. The compositions of oil samples were dominated by monoterpenes: α-pinene sabinene, and terpinen-4-ol. Chamazulene and dihydrochamazulene isomers as well as various hemiterpene esters and analogs have been identified. To evidence a chemical variability, statistical analysis performed on 13 oil sample compositions allowed partitioning into three groups, mainly differentiated by their contents of sabinene, camphor, borneol, terpinen-4-ol, and germacrene D.

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Section: Resultsmentioning

confidence: 99%

Composition and Chemical Variability of the Essential Oil from Aerial Parts of Cladanthus scariosus, an Endemic Species to the Moroccan High Atlas

Tomi

Hafidi

Bakhy

et al. 2022

Chemistry & Biodiversity

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“…Elouaddari et al (2019) [ 32 ] examined the chemical composition and biological activities of C. mixtus essential oils (EOs). According to the authors review, a total of 264 compounds constitute the EOs of C. mixtus , which vary greatly depending on diverse parameters, including geographies, plant parts, extraction methods, and ecological factors.…”

Section: Discussionmentioning

confidence: 99%

Chemical Characterization and Several Bioactivities of Cladanthus mixtus from Morocco

et al. 2023

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The purpose of this work was to investigate, for the first time to our knowledge, the chemical composition and bioactivity of methanolic extracts (roots, stems, leaves, and flowers) from Cladanthus mixtus (L.) Chevall. that grows wild in northern Morocco (the Tangier-Tetouan-Al Hoceima region). The phenolic and flavonoid contents were determined by spectrophotometer methods, and the composition of derivatized methanolic extracts from C. mixtus using N-O-bis(trimethylsilyl) trifluoroacetamide (BSTFA) was analyzed by gas chromatography–mass spectrometry (GC-MS). The antioxidant activity was carried out by applying the 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and DPPH (2,2-diphenyl-1-picrylhydrazyl) tests. The micro-dilution technique was chosen to investigate the antimicrobial activity of methanolic extracts against two bacterial strains and three fungal species. The results showed that the values of total phenolic and flavonoid contents were found to be higher in flower extracts (30.55 ± 0.85 mg of gallic acid equivalents (GAE)/g of dried weight (DW) and 26.00 ±1.34 mg of quercetin equivalents (QE)/g DW, respectively). Other groups of chemical compounds were revealed by GC-MS, such as carbohydrates (27.25–64.87%), fatty acids (1.58–9.08%), organic acids (11.81–18.82%), and amino acids (1.26–7.10%). Root and flower methanolic extracts showed the highest antioxidant activity using ABTS (39.49 mg of Trolox equivalents (TE)/g DW) and DPPH (36.23 mg TE/g DW), respectively. A positive correlation between antioxidant activity and polyphenol and flavonoid amounts was found. Antibacterial tests showed that the best activity was presented by the leaf extract against Staphylococcus aureus (minimum inhibitory concentration (MIC) = minimum bactericidal concentration (MBC) = 20 mg/mL) and Escherichia coli (MIC of 30 mg/mL and MBC of 35 mg/mL). S. aureus was more sensitive to the extracts compared to E. coli. All extracts showed antifungal activity against Trichophyton rubrum, with the best efficacy reported by the flower and leaf extracts (MIC = 1.25 mg/mL and minimum fungicidal concentration (MFC) = 2.5 mg/mL). In general, extracts of C. mixtus appeared less effective against Candida albicans and Aspergillus fumigatus.

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“…In fact, several factors affect the chemical properties of the plant, among others such as, genetic diversity, the parts used for the isolation of EOs, climatic conditions, etc. 29,40 Furthermore, the bioactive compounds present in EOs in general can vary qualitatively and depend quantitatively on the seasonal sampling period, growing conditions, environmental factors and geographical location. 41…”

Section: Chemical Composition Of Eosmentioning

confidence: 99%

Wild Chamomile (Matricaria recutita L) from the Taounate Province, Morocco: Extraction and Valorisation of the Antibacterial Activity of its Essential Oils

2021

TJNPR

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This species is considered to be one of the most famous medicinal plants commonly consumed as herbal teas and teas. Moreover, some statistics show that every day more than a million glasses of camomile tea are drunk. 8 The properties of M. recutita are numerous; therapeutic, cosmetic, agri-food, etc. 9 From one hand, this plant is used for the treatment of various diseases, including those related to inflammatory conditions, 2 bacterial and gastrointestinal infections, 10 muscle spasms, 11 etc. On the other hand, the oils extracted from chamomile can be used in cosmetics and perfumery. 2 This oil is known for its best quality and is generally known as "blue oil" due to the presence of certain chemical compounds, such as terpenoids, in particular chamazulene and bisabolol. 12 Chamomile is an economic asset. However, recent evidence has shown that the emergence of resistant microorganisms is increasingly restricting the effectiveness and potency of commercially available drugs. 13 This can lead to failure in the treatment and management of infections. 14 In addition to this, it has been estimated that the steadily increasing resistance to antibiotics will lead to around 10 million deaths every year by 2050. 15 To this effect, medicinal plants have proven to be more effective and cheaper than conventional drugs in the treatment of various diseases. Furthermore, they have shown less and even none of the side effects. 16 In spite of all these studies and scientific literature, chamomile planted in Taounate area of Morocco has so far not been the subject of such a detailed study in terms of phytochemicals and antibacterial activities. We have therefore oriented our study in this direction with the aims of (i) extracting the essential oils from the aerial parts of M. recutita by two methods and then comparing these two methods, (ii) separating and identifying the chemical compounds by the GC-MS method, and (iii) evaluating in vitro the antibacterial activity of the essential oils of M. recutita against four pathogenic bacterial strains (Escherichia coli ATB: 57) B6N, Staphylococcus aureus, Bacillus subtills and Pseudomonas aeruginosa).

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Chemical Composition and Biological Activities of the Cladanthus mixtus Essential Oil: A Review

Cited by 6 publications

References 34 publications

Composition and Chemical Variability of the Essential Oil from Aerial Parts of Cladanthus scariosus, an Endemic Species to the Moroccan High Atlas

Composition and Chemical Variability of the Essential Oil from Aerial Parts of Cladanthus scariosus, an Endemic Species to the Moroccan High Atlas

Chemical Characterization and Several Bioactivities of Cladanthus mixtus from Morocco

Wild Chamomile (Matricaria recutita L) from the Taounate Province, Morocco: Extraction and Valorisation of the Antibacterial Activity of its Essential Oils

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