Composition and Chemical Variability of the Essential Oil from Aerial Parts of <i>Cladanthus scariosus</i>, an Endemic Species to the Moroccan High Atlas

Tomi, Félix; Hafidi, Souad El; Bakhy, Khadija; Ouhssine, Mohammed; Benzakour, Abderrahim; Khamar, Hamid; Casanova, Joseph; Paoli, Mathieu

doi:10.1002/cbdv.202201022

Cited by 2 publications

(4 citation statements)

References 29 publications

(46 reference statements)

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“…The data obtained in this work basically agreed with the compositions of the EOs from other accessions of C. scariosus previously published [ 18 , 48 , 49 ], although some differences should be noted. As can be seen from Table 2 , the major compounds identified in C. scariosus , such as α -pinene, sabinene, chamazulene, and germacrene D ( Table 3 ), are present in all the other accessions collected in different places in the Moroccan territory.…”

Section: Resultssupporting

confidence: 90%

“…It is a perennial plant with a strong aromatic odor, ranging from 30 to 60 cm in height; the stems are erect and ended by flower heads with orange-yellow ligules ( Figure 1 ). This species is quite common in open areas on sandstone and is found in the Moroccan High Atlas [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

“…C. scariosus , known in Morocco by several vernacular names (“ Irezghi , Irezgui , Itzghi , Ifskin’uarras , Gartûfa ”), is generally used to treat all disorders where spasms are important symptoms; it has tonic, stomachic, analgesic, and antispasmodic properties [ 18 ]. Furthermore, the tea of its leaves and inflorescences is used for gastrointestinal, gynecological, and pediatric troubles and for the treatment of diabetes [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

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Cladanthus scariosus Essential Oil and Its Principal Constituents with Cytotoxic Effects on Human Tumor Cell Lines

Badalamenti,

Ilardi,

Bruno

et al. 2024

Plants

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Cladanthus is a small genus of the Asteraceae family comprising just five species that, apart from Cladanthus mixtus (L.) Chevall., has a large distribution in all the Mediterranean countries, mainly in the North Africa area. Several ethnopharmacological uses have been reported for species of this genus. Notably, Cladanthus scariosus (Ball) Oberpr. & Vogt is endemic to Morocco. Seeking to delve deeper into the phytochemistry and pharmacological aspects of this species, in this work, we investigated the essential oil (EO) obtained from the aerial parts of a locally sourced accession, hitherto unexplored, growing wild near Tizi n’Ticha, Morocco. The chemical composition of the EO, obtained by the hydrodistillation method, was evaluated by GC and GC-MS. The most abundant EO constituent was germacrene D (13.2%), the principal representative of the sesquiterpene hydrocarbons class (27.2%). However, the major class of constituents was monoterpene hydrocarbons (43.0%), with α-pinene (11.9%), sabinene (10.2%), p-cymene (8.5%), and α-phellandrene (5.2%) as the most abundant. The EO and its main constituents have been tested for their possible cytotoxic activity against three human tumor cell lines (MDA-MB 231, A375, and CaCo2) using the MTT assay, with corresponding IC50 values of 13.69, 13.21, and 22.71 µg/mL, respectively. Germacrene D and terpinen-4-ol were found to be the most active constituents with IC50 values between 3.21 and 9.53 µg/mL. The results demonstrate remarkable cytotoxic activity against the three human tumor cell lines studied, and in the future, further analyses could demonstrate the excellent potential of C. scariosus EO as an antitumor agent.

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Section: Resultssupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cladanthus scariosus Essential Oil and Its Principal Constituents with Cytotoxic Effects on Human Tumor Cell Lines

Badalamenti,

Ilardi,

Bruno

et al. 2024

Plants

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“…With feathery leaves and a daisy-like appearance with gold or white flowers, in general, these Mediterranean plants do not go unnoticed in fields and gardens. The prevalent species in Morocco are C. scariosus which is endemic in the High Atlas area [1,2] and the flavonoid-rich species C. mixtus in other areas [3]. The latter Cladanthus species is a prominent source of polyphenols and flavonoids, such as the glycosyl-flavone acetylisospinosin, which has recently been identified together with many other flavonoids [4,5].…”

Section: Introductionmentioning

confidence: 99%

The Medicinal Moroccan Plant Cladanthus arabicus as a Prominent Source of Sesquiterpenes Cladantholide and Sintenin

Bouissane,

Bailly

2024

AppliedChem

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The yellow-flowering plant Cladanthus arabicus (L.) Cass., commonly called Arabian Cladanthus or palm springs daisy, is typical of the West Mediterranean region and is particularly abundant in Morocco. The plant is used in traditional Moroccan medicine for the treatment of diabetes and other ailments. Over the past 20 years, this abundant wild plant has been neglected from a phytochemical viewpoint. For the first time, the present review provides a survey of the pharmacological properties reported from extracts of C. arabicus and from essential oils derived from the aerial parts, mainly antimicrobial, antioxidant, and anti-inflammatory properties. The main bioactive natural products are discussed, with a focus on two rare sesquiterpenes of major interest, which are abundant in the stems and leaves: the 6,12-guaianolide cladantholide and the germacranolide sintenin. These sesquiterpene lactones and their analogues are presented to highlight their properties, extraction or total synthesis, and their therapeutic benefits. They both represent convenient biosourced precursors for the synthesis of derivatives. Sintenin may be used as a starting material for the design of hemi-synthetic germacradienolide-type costunolide or parthenolide derivatives. The 6,12-guaianolide scaffold of cladantholide offers opportunities to design novel arglabin derivatives. The therapeutic potential of the neglected and under-utilized plant Cladanthus arabicus and its original phytochemicals shall be explored further.

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Composition and Chemical Variability of the Essential Oil from Aerial Parts of Cladanthus scariosus, an Endemic Species to the Moroccan High Atlas

Cited by 2 publications

References 29 publications

Cladanthus scariosus Essential Oil and Its Principal Constituents with Cytotoxic Effects on Human Tumor Cell Lines

Cladanthus scariosus Essential Oil and Its Principal Constituents with Cytotoxic Effects on Human Tumor Cell Lines

The Medicinal Moroccan Plant Cladanthus arabicus as a Prominent Source of Sesquiterpenes Cladantholide and Sintenin

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